Iron (Ferrous glycine sulphate) + Vitamin B-Complex + Vitamin C + Amino acids Pharmacology

Iron (Ferrous glycine sulphate) + Vitamin B-Complex + Vitamin C + Amino acids

About Iron (Ferrous glycine sulphate) + Vitamin B-Complex + Vitamin C + Amino acids
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Mechanism of Action of Iron (Ferrous glycine sulphate) + Vitamin B-Complex + Vitamin C + Amino acids
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Pharmacokinets of Iron (Ferrous glycine sulphate) + Vitamin B-Complex + Vitamin C + Amino acids
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Onset of Action for Iron (Ferrous glycine sulphate) + Vitamin B-Complex + Vitamin C + Amino acids
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Duration of Action for Iron (Ferrous glycine sulphate) + Vitamin B-Complex + Vitamin C + Amino acids
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Half Life of Iron (Ferrous glycine sulphate) + Vitamin B-Complex + Vitamin C + Amino acids
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Side Effects of Iron (Ferrous glycine sulphate) + Vitamin B-Complex + Vitamin C + Amino acids
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Contra-indications of Iron (Ferrous glycine sulphate) + Vitamin B-Complex + Vitamin C + Amino acids
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Special Precautions while taking Iron (Ferrous glycine sulphate) + Vitamin B-Complex + Vitamin C + Amino acids
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Pregnancy Related Information
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Old Age Related Information
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Breast Feeding Related Information
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Children Related Information
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Indications for Iron (Ferrous glycine sulphate) + Vitamin B-Complex + Vitamin C + Amino acids
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Interactions for Iron (Ferrous glycine sulphate) + Vitamin B-Complex + Vitamin C + Amino acids
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Typical Dosage for Iron (Ferrous glycine sulphate) + Vitamin B-Complex + Vitamin C + Amino acids
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Schedule of Iron (Ferrous glycine sulphate) + Vitamin B-Complex + Vitamin C + Amino acids
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Storage Requirements for Iron (Ferrous glycine sulphate) + Vitamin B-Complex + Vitamin C + Amino acids
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Effects of Missed Dosage of Iron (Ferrous glycine sulphate) + Vitamin B-Complex + Vitamin C + Amino acids
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Effects of Overdose of Iron (Ferrous glycine sulphate) + Vitamin B-Complex + Vitamin C + Amino acids
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Iron (Ferrous glycine sulphate)

About Iron (Ferrous glycine sulphate)
Oral iron preparation, An iron-containing salt, Antianemic,hematinic
Mechanism of Action of Iron (Ferrous glycine sulphate)
Ferrous glycine sulfate is a chelate of ferrous sulfate and glycine used as a source of iron for iron-deficiency anaemia. It is given by mouth in doses containing the equivalent of up to 150 mg of iron daily. It exerts haematinic action by being an essential constituent of haemoglobin. It is necessary for the oxidative process of living tissues.
It has relatively high bioavailability in the presence of dietary inhibitors. Chelates prevent iron from binding to inhibitors in food or precipitating as insoluble ferric hydroxide in the pH of the small intestine.
Pharmacokinets of Iron (Ferrous glycine sulphate)
Absorption: Absorbed orally in ferrous form and poorly absorbed in healthy individuals (about 10%) but in patients suffering from iron deficiency anaemia up to 60% dose is absorbed. Distribution: Transported in a transferrin bound form in to bone marrow for incorporation in to haemoglobin. Metabolism: Iron liberated by destruction of haemoglobin is reused by the body. Excretion: Excretion of iron is minimal. Loss usually occurs in nails, faeces, urine, hair, sweat, and bile.
Onset of Action for Iron (Ferrous glycine sulphate)
N/A
Duration of Action for Iron (Ferrous glycine sulphate)
N/A
Half Life of Iron (Ferrous glycine sulphate)
N/A
Side Effects of Iron (Ferrous glycine sulphate)
1.Nausea
2.Epigasttric distress
3.Vomiting
4.Constipation
5.Diarrhoea
6.Black stools
7.Temporary staining of teeth with liquid formulations
Contra-indications of Iron (Ferrous glycine sulphate)
1.Haemolytic anaemia unless iron deficiency anaemia is also present
2.Haemochromatosis
3.Haemosiderosis
4.Peptic ulcer
5.Regional enteritis
6.Ulcerative colitis
7.Those receiving repeated blood transfusions.
Special Precautions while taking Iron (Ferrous glycine sulphate)
1. Prolonged use
2. Minimise gastrointestinal discomfort by taking along with meals and gradually increasing the recommended dosage
3. Discontinue if intolerance occurs
4. Higher doses are required for geriatric patients
Pregnancy Related Information
May be used
Old Age Related Information
Use with caution
Breast Feeding Related Information
May be used
Children Related Information
Use with caution
Indications for Iron (Ferrous glycine sulphate)
1. Iron deficiency
2. Iron deficiency anaemia
Interactions for Iron (Ferrous glycine sulphate)
N/A
Typical Dosage for Iron (Ferrous glycine sulphate)
Adult: I capsule or 10ml once or twice daily after meals.
Children: 5-10 ml twice daily after meals.
Schedule of Iron (Ferrous glycine sulphate)
N/A
Storage Requirements for Iron (Ferrous glycine sulphate)
Store in a well closed container in a cool dry place. Protect from light.
Effects of Missed Dosage of Iron (Ferrous glycine sulphate)
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Iron (Ferrous glycine sulphate)
Treatment includes immediate support of airway, respiration, and circulation. In conscious patients induce emesis with ipecac; if not empty stomach by gastric lavage. Follow emesis with lavage, using a 1% sodium bicarbonate solution to convert iron to less irritating poorly absorbed form. Take abdominal X-ray to determine presence of excess iron. Deferoxamine may be used for systemic chelation if serum levels of iron exceed 350mg/dl.

Vitamin B-Complex

About Vitamin B-Complex
Vitamin B-complex are group of vitamins, which include Thiamine (B1),Riboflavin (B2),Niacin (B3),Pantothenic acid (B5),Pyridoxine (B6),Cyanocobalamin (B12),Folic acid and Biotin.
These vitamins are essential for the breakdown of carbohydrates into glucose (this provides energy for the body),the breakdown of fats and proteins (which aids the normal functioning of the nervous system),muscle tone in the stomach and intestinal tract,Skin,Hair,Eyes,Mouth and Liver
Mechanism of Action of Vitamin B-Complex
N/A
Pharmacokinets of Vitamin B-Complex
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Onset of Action for Vitamin B-Complex
N/A
Duration of Action for Vitamin B-Complex
N/A
Half Life of Vitamin B-Complex
N/A
Side Effects of Vitamin B-Complex
1.Drowsiness
2.Headache
3.Diarrhoea
4.Nausea.
5.Numbness of the skin
Contra-indications of Vitamin B-Complex
Hypersensitivity to the ingredient of Vitamin B-complex
Special Precautions while taking Vitamin B-Complex
1.Pernecious anaemia
2.Patient receiving dialysis
Pregnancy Related Information
May be used.
Old Age Related Information
May be used.
Breast Feeding Related Information
May be used.
Children Related Information
May be used.
Indications for Vitamin B-Complex
1.Vitamin deficiency states
2. As an adjuvant to antibiotic therapy
3. Combinations with lactobacillus are indicated in aphthous stomatitis, thrush.
Interactions for Vitamin B-Complex
Sulfinpyrazone: Uricosuric effect of sulfinpyrazone may be inhibited by niacin.
Levodopa: Pyridoxine reduces efficacy of levodopa. Avoid supplemental vitamins that contain greater then 5 mg pyridoxine in the daily dose.
Phenobarbital: Serum levels of Phenobarbital may be decreased if used concomitantly with pyridoxine.
Phenytoin: Pyridoxine decreases serum levels of phenytoin.
Dapsone: PABA antagonizes anti-malarial effect of dapsone.
Typical Dosage for Vitamin B-Complex
I tablet /day
Schedule of Vitamin B-Complex
N/A
Storage Requirements for Vitamin B-Complex
Store at room temperature. Keep out of the reach of children.Protect from heat, light and moisture.
Effects of Missed Dosage of Vitamin B-Complex
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose.Continue the regular schedule. Do not double the dose.
Effects of Overdose of Vitamin B-Complex
Give supportive measures and symptomatic treatment.

Vitamin C

About Vitamin C
Water soluble vitamin, antioxidant.
Mechanism of Action of Vitamin C
Vitamin C exerts it`s action by influencing the biologic oxidations and reductions used in cellular respirations. It directly stimulates collagen synthesis and maintains intracellular connective tissue. It involves in various metabolic reactions such as 1).Hydroxylation of praline and lysine residues of protocollagen which is essential for formation and stabilization of collagen triple helix, 2).hydroxylation of carnitine, 3).Conversion of folic acid to folinic acid, 4).biosynthesis of adrenal steroids, catecholamines, oxytocin, and ADH, 5).Metabolism of cyclic nucleotides and prostaglandins. Vitamin C is important in resistance to infections.
Pharmacokinets of Vitamin C
Absorption: Well absorbed orally.
Distribution: Widely distributed both extracellularly and intracellularly, It crosses the placenta and also distributed in to the breast milk.
Metabolism: Metabolized in the liver; partly oxidized in to active dehydroascorbic acid and inactive metabolites.
Excretion: Inactive metabolites and extra drug is excreted through urine.
Onset of Action for Vitamin C
N/A
Duration of Action for Vitamin C
N/A
Half Life of Vitamin C
N/A
Side Effects of Vitamin C
1. Discomfort at injection site
2. Acid urine
3. Renal calculi
4. Oxaluria
Contra-indications of Vitamin C
No known contraindications
Special Precautions while taking Vitamin C
1. Renal impairment
2. Ingestion of large doses during pregnancy has resulted in scurvy in neonates
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
May be used
Indications for Vitamin C
1. Scurvy
2. Prophylaxis and treatment of vitamin C deficiency
3. As an antioxidant to maintain natural colour and flavour of food items
4. For acidification of urine
5. Capillary fragility
6. Dental caries

Interactions for Vitamin C
Oral contraceptives and estrogens: Vitamin C increases serum levels of oestrogen resulting in adverse reactions .
Warfarin: The anticoagulant effects of warfarin is reduced.
Lab Tests: Large doses (>500 mg) of vitamin C may cause false negative urine glucose determinations. May result in false negative amine dependent stool occult blood tests.
Typical Dosage for Vitamin C
Oral:
Adults: 50 to 1000mg/day depending up on the requirement.
Pregnancy and lactation: 100 to 150mg/day
Children: 30 to 100mg/day.
Scurvy:
Oral:
Adults: 1000mg twice daily to thrice daily.
Children: 300mg to 1000mg daily.
Sub clinical scurvy:
Oral, S.C., I.M., or I.V.: 100 to 250mg once daily or twice daily depending up on the severity of the condition. Then give a maintenance dosage of 50mg/day.
Children: 100 to 300mg depending up on the severity. Then give a maintenance dose of 35mg/day.

Schedule of Vitamin C
C1 (Oral)
C (Parenteral)
Storage Requirements for Vitamin C
Store in a cool dry area in a well closed container. Protects from moisture, light and direct heat.
Effects of Missed Dosage of Vitamin C
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Vitamin C
Discontinue the therapy and provide symptomatic and supportive measures.

Amino acids

About Amino acids
An amino acid is any molecule that contains both amine and carboxyl functional groups. These amino acids are the basic components of proteins. There are twenty standard amino acids used by cells in protein biosynthesis that are specified by the general genetic code.
Amino acids are joined to each other by peptide bonds. A peptide bond is a chemical bond formed between two molecules (carboxyl group of one molecule reacts with the amino group of the other molecule), releasing a molecule of water (H2O). The resulting CO-NH bond is called a peptide bond, the chemical bond that links the amino acid monomers in a protein chain. Each protein has its own unique amino acid sequence that is known as its primary structure. Amino acids can be linked together in varying sequences to form a huge variety of proteins. The unique shape of each protein determines its function in the body.
Aminoacids are of 2 types, essential and nonessential. Essential amino acids are the ones that must be obtained in the diet and non-essential are synthesized within the body
Essential aminoacids: Methionine, Threonine, Tryptophan, Valine, Isoleucine, Leucine, Lysine, Phenylalanine, Histidine,
Nonessential aminoacids: Alanine, Asparagine, Aspartic acids, Proline, Glutamic acid, Glutamine, Serine
Amino acids Arginine, Cysteine, Glycine and Tyrosine are considered conditionally essential, meaning they are not normally required in the diet, but must be supplied exogenously to specific populations that do not synthesize it in adequate amounts
Histidine and Arginine are generally only considered essential in children, because the metabolic pathways that synthesize these amino acids are not fully developed in children.
Nutritional role of aminoacids: Aminoacids have been used orally or in relatively dilute solutions intravenously as supplementary nutrients for patients unable to metabolize intact protein adequately. For patients in whom oral or tube feeding is contraindicated or Inadequate good nutrition may be achieved or maintained by intravenous feeding known as total parenteral nutrition or intravenous or parenteral hyperalimentation. Such feeding provides essential nutrients in a sufficiently concentrated form that does not exceed normal daily fluid requirements.

Mechanism of Action of Amino acids
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Pharmacokinets of Amino acids
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Onset of Action for Amino acids
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Duration of Action for Amino acids
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Half Life of Amino acids
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Side Effects of Amino acids
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Contra-indications of Amino acids
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Special Precautions while taking Amino acids
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Pregnancy Related Information
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Old Age Related Information
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Breast Feeding Related Information
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Children Related Information
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Indications for Amino acids
1.Hypoproteinaemia
2.Pre and post surgery
Interactions for Amino acids
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Typical Dosage for Amino acids
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Schedule of Amino acids
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Storage Requirements for Amino acids
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Effects of Missed Dosage of Amino acids
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Effects of Overdose of Amino acids
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