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- Pharmacology For Iron (Ferrous gluconate) + Vit B12 + Vit B6 + Folic acid + Vitamin C + Dioctyl Sodium Sulphosuccinate
Iron (Ferrous gluconate) + Vit B12 + Vit B6 + Folic acid + Vitamin C + Dioctyl Sodium Sulphosuccinate Pharmacology
Iron (Ferrous gluconate) + Vit B12 + Vit B6 + Folic acid + Vitamin C + Dioctyl Sodium Sulphosuccinate
About Iron (Ferrous gluconate) + Vit B12 + Vit B6 + Folic acid + Vitamin C + Dioctyl Sodium SulphosuccinateN/AMechanism of Action of Iron (Ferrous gluconate) + Vit B12 + Vit B6 + Folic acid + Vitamin C + Dioctyl Sodium SulphosuccinateN/APharmacokinets of Iron (Ferrous gluconate) + Vit B12 + Vit B6 + Folic acid + Vitamin C + Dioctyl Sodium SulphosuccinateN/AOnset of Action for Iron (Ferrous gluconate) + Vit B12 + Vit B6 + Folic acid + Vitamin C + Dioctyl Sodium SulphosuccinateN/ADuration of Action for Iron (Ferrous gluconate) + Vit B12 + Vit B6 + Folic acid + Vitamin C + Dioctyl Sodium SulphosuccinateN/AHalf Life of Iron (Ferrous gluconate) + Vit B12 + Vit B6 + Folic acid + Vitamin C + Dioctyl Sodium SulphosuccinateN/ASide Effects of Iron (Ferrous gluconate) + Vit B12 + Vit B6 + Folic acid + Vitamin C + Dioctyl Sodium SulphosuccinateN/AContra-indications of Iron (Ferrous gluconate) + Vit B12 + Vit B6 + Folic acid + Vitamin C + Dioctyl Sodium SulphosuccinateN/ASpecial Precautions while taking Iron (Ferrous gluconate) + Vit B12 + Vit B6 + Folic acid + Vitamin C + Dioctyl Sodium SulphosuccinateN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Iron (Ferrous gluconate) + Vit B12 + Vit B6 + Folic acid + Vitamin C + Dioctyl Sodium SulphosuccinateN/AInteractions for Iron (Ferrous gluconate) + Vit B12 + Vit B6 + Folic acid + Vitamin C + Dioctyl Sodium SulphosuccinateN/ATypical Dosage for Iron (Ferrous gluconate) + Vit B12 + Vit B6 + Folic acid + Vitamin C + Dioctyl Sodium SulphosuccinateN/ASchedule of Iron (Ferrous gluconate) + Vit B12 + Vit B6 + Folic acid + Vitamin C + Dioctyl Sodium SulphosuccinateN/AStorage Requirements for Iron (Ferrous gluconate) + Vit B12 + Vit B6 + Folic acid + Vitamin C + Dioctyl Sodium SulphosuccinateN/AEffects of Missed Dosage of Iron (Ferrous gluconate) + Vit B12 + Vit B6 + Folic acid + Vitamin C + Dioctyl Sodium SulphosuccinateN/AEffects of Overdose of Iron (Ferrous gluconate) + Vit B12 + Vit B6 + Folic acid + Vitamin C + Dioctyl Sodium SulphosuccinateN/AIron (Ferrous gluconate)
About Iron (Ferrous gluconate)Oral iron preparation, iron(II) salt of gluconic acid, Antianemic,hematinic.Mechanism of Action of Iron (Ferrous gluconate)Ferrous gluconate is used as a source of iron for iron-deficiency anaemia. It is given by mouth in doses of up to 1.8 g daily (equivalent to up to 210 mg of iron daily). Iron formulations exert haematinic action by being an essential constituent of haemoglobin. It is necessary for the oxidative process of living tissues.Pharmacokinets of Iron (Ferrous gluconate)Absorption: Absorbed orally in ferrous form and poorly absorbed in healthy individuals (about 10%) but in patients suffering from iron deficiency anaemia up to 60% dose is absorbed. Distribution: Transported in a transferrin bound form in to bone marrow for incorporation in to haemoglobin. Metabolism: Iron liberated by destruction of haemoglobin is reused by the body. Excretion: Excretion of iron is minimal. Loss usually occurs in nails, faeces, urine, hair, sweat, and bile.Onset of Action for Iron (Ferrous gluconate)N/ADuration of Action for Iron (Ferrous gluconate)N/AHalf Life of Iron (Ferrous gluconate)N/ASide Effects of Iron (Ferrous gluconate)1.Nausea
2.Epigasttric distress
3.Vomiting
4.Constipation
5.Diarrhoea
6.Black stools
7.Temporary staining of teeth with liquid formulations
Contra-indications of Iron (Ferrous gluconate)1.Haemolytic anaemia unless iron deficiency anaemia is also present
2.Haemochromatosis
3.Haemosiderosis
4.Peptic ulcer
5.Regional enteritis
6.Ulcerative colitis
7.Those receiving repeated blood transfusions.
Special Precautions while taking Iron (Ferrous gluconate)1. Prolonged use
2. Minimise gastrointestinal discomfort by taking along with meals and gradually increasing the recommended dosage
3. Discontinue if intolerance occurs
4. Higher doses are required for geriatric patients
Pregnancy Related InformationMay be usedOld Age Related InformationUse with cautionBreast Feeding Related InformationMay be usedChildren Related InformationUse with cautionIndications for Iron (Ferrous gluconate)1. Iron deficiency
2. Iron deficiency anaemiaInteractions for Iron (Ferrous gluconate)N/ATypical Dosage for Iron (Ferrous gluconate)Oral:
Ferrous gluconate:
300 to 1200mg daily in three to four divided doses.
Children (age 2 to 12): 3mg/kg/day in three to four divided doses
Children (age 6months to 2years): 3 to 6mg/kg/day in three to four divided doses
Infants: 10 to 25mg/day in three to four divided doses.
Schedule of Iron (Ferrous gluconate)HStorage Requirements for Iron (Ferrous gluconate)Store in a well closed container in a cool dry place. Protect from light.Effects of Missed Dosage of Iron (Ferrous gluconate)Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Iron (Ferrous gluconate)Treatment includes immediate support of airway, respiration, and circulation. In conscious patients induce emesis with ipecac; if not empty stomach by gastric lavage. Follow emesis with lavage, using a 1% sodium bicarbonate solution to convert iron to less irritating poorly absorbed form. Take abdominal X-ray to determine presence of excess iron. Deferoxamine may be used for systemic chelation if serum levels of iron exceed 350mg/dl. Vit B12
About Vit B12N/AMechanism of Action of Vit B12Vitamin B12 is an essential constituent for growth, cell reproduction, hematopoiesis, and nucleoprotein and myelin synthesis. Vitamin B12 is converted in to coenzyme B12 in the tissues which is essential for conversion of methyl-malonate to succinate and synthesis of methionine from homocystine. It is also associated with fat and carbohydrate metabolism and protein synthesis. Cells characterized by rapid division such as epithelial cells, bone marrow, and myeloid cells appear to have greatest requirement of Cyanocobalamin.Pharmacokinets of Vit B12Absorption: Absorbed irregularly after oral administration and absorption depends on Ca and intrinsic factor. It is also administered subcutaneously and intramuscularly.
Distribution: Distributed in to liver, bone marrow, and other tissues. It crosses the placenta and appears in breast milk.
Metabolism: It is metabolized in liver.
Excretion: In normal dosage it is reabsorbed from bile and a minute portion is excreted through urine but the extra drug is excreted through urine.
Onset of Action for Vit B12N/ADuration of Action for Vit B12N/AHalf Life of Vit B12N/ASide Effects of Vit B121. Anaphylaxis
2. Anaphylactoid reactions
3. Pain and burning sensation at injection site
4. Itching
5. Urticaria
6. Transient diarrhea
7. Peripheral vascular thrombosis
8. Pulmonary oedema
Contra-indications of Vit B121. Hypersensitivity to the drug
2. Leber`s disease
Special Precautions while taking Vit B121. Anemic patients with coexisting cardiac, pulmonary and hypertensive diseases.Pregnancy Related InformationMay be usedOld Age Related InformationMay be usedBreast Feeding Related InformationMay be usedChildren Related InformationUse with caution
NEONATES : Use with caution
Indications for Vit B121. Vitamin B12 deficiency
2. Pernicious Anaemia
3. Peripheral neuropathy (diabetic, alcoholic, and drug induced)
Interactions for Vit B12N/ATypical Dosage for Vit B12I.M., S.C.:
Pernicious Anaemia: 100mcg daily for 1 week followed by the same dose given on alternate days for 7 doses and then every 3 to 4days for another 3 weeks. This regimen should be followed by 100mcg monthly for life. Concurrently administer folic acid if required.
Vitamin B12 deficiency other than pernicious Anaemia: 30mcg daily for 5 to 10days depending up on the severity of the condition.
Maintenance dosage: 100 to 200mcg once monthly.
Children: 100mcg I.M. or S.C. over the course of 2 or more weeks.
Maintenance dosage: 60mcg monthly I.M. or S.C.
Schilling test flushing dose:
Adults and Children: 1000mcg I.M. in single dose
Recommended RDA (recommended dietary allowance) for Vitamin B12:
Infants up to 6months of age: 0.3mcg.
Children age 6 months to 1 year: 0.5mcg.
Children age 1 to 3: 0.7mcg.
Children age 4 to 6: 1mcg.
Children age 7 to 10: 1.4mcg.
Children age 11 to adult: 2mcg..
Pregnant women: 2.2mcg.
Breast feeding women: 2.6mcg.
Schedule of Vit B12CStorage Requirements for Vit B12Store at room temperature range of 15 to 30 degree C.in a light resistant well closed container in a dry place.Effects of Missed Dosage of Vit B12Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Vit B12Not applicable. Even in large doses Vitamin B12 isn`t usually toxic.Vit B6
About Vit B6Physiological functions: It is involved as a coenzyme (Pyridoxal phosphate) in metabolism of tryptophan, in several metabolic transformations of amino acids including transamination, decarboxylation & racemization.
Deficiency symptoms: Peripheral neuritis, seizures, stomatitis, glossitis, anaemia, seborrhea like lesions.Mechanism of Action of Vit B6Vitamin B6 is a collective term for Pyridoxine, Pyridoxal, Pyridoxamine and their phosphorylated derivatives such as Pyridoxine phosphate, Pyridoxal phosphate and Pyridoxamine derivatives respectively. Vitamin B6 is essential for the metabolism of amino acid, glycogen and fatty acids, for nerve functions, for the formation of red blood cells and also helps the skin healthy. Vitamin B6 is also used for the synthesis of nucleic acid, Haemoglobin, Sphingomyelin, other Sphingolipids, Serotonin, Dopamine, Noradrenaline and GABA.Pharmacokinets of Vit B6Absorption: Vitamin B6 is readily absorbed after oral administration.
Distribution: It is mainly distributed in the body in protein bound form. It is stored primarily in the liver and to a lesser extent muscle and brain.
Metabolism: It is metabolised in the liver
Onset of Action for Vit B6N/ADuration of Action for Vit B6N/AHalf Life of Vit B615-20 daysSide Effects of Vit B61. Neuropathy
2. Unstable gait
3. Drowsiness
4. Perioral numbness
5. Paresthesia
6. Numbness of feet
7. Somnolence
8. Sensory neuropathy
9. Ataxia
Contra-indications of Vit B61. Hypersensitivity to Vitamin B6Special Precautions while taking Vit B6N/APregnancy Related InformationMay be usedOld Age Related InformationMay be usedBreast Feeding Related InformationUse with cautionChildren Related InformationUse with caution
NEONATES: Contraindicated
Indications for Vit B61. Vitamin B6 deficiency including inadequate diet and drug induced causes
2. Neuropathy
3. Premenstrual syndrome
4. Hyperoxaluria type 1
5. Metabolic disorder
6. Isoniazid poisoning
Interactions for Vit B6Cycloserine, Hydralazine, Isoniazide, Oral contraceptive, Penicillamine: Increase Pyridoxine requirement.
Levodopa: Pyridoxine reverses the therapeutic effect of Levodopa.
Phenobarbital, Phenytoin: Pyridoxine decreases serum level of these anticonvulsants.
Typical Dosage for Vit B6Adult: 10 - 20 mg / day
Dietary deficiency: 2.5 -10 mg / day for effective therapeutic response is obtained.
Maintenance dose: 2 - 5 mg / day for several weeks.
Drug induced deficiency: 100 - 200 mg / day for 3 weeks.
Maintenance dose: 25 - 100 mg / day
Neuropathy: 50 - 200 mg /day
Premenstrual syndrome: 40 - 500 mg / day
Hyperoxaluria type 1: 25 - 300 mg / day
Metabolic disorder: 100-500 mg /day.
Isoniazid poisoning: Initial dose: 1 - 4 g as IV administration, then 1 g IM every 30 minute until Pyridoxine dose is equal to the Isoniazid dose has been given.
Schedule of Vit B6N/AStorage Requirements for Vit B6Store it at 15 - 30 degree C. Protect from moisture and heat.Effects of Missed Dosage of Vit B6Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Vit B6Give supportive measures and symptomatic treatment. The signs of Pyridoxine overdose can be resolved by discontinuation (withdrawal) of Pyridoxine.Folic Acid
About Folic AcidDietary supplement, Folate derivative( B9 ), Water Soluble Vitamin.Mechanism of Action of Folic AcidFolic acid reduced by enzymes folate reductase and dihydrofolate reductase and forms dihydrofolic acid tetrahydrofolic acid respectively. Tetrahydrofolic acid acts as a coenzyme which mediates a number of one carbon transfer reactions by carrying a methyl group as an adduct. It involves a number of reactions such as 1).conversion of homocysteine to methionine. 2).synthesis of thymidylate which is an essential constituent of DNA from methylene-tetrahydrofolic acid. 3). Conversion of serine to glycine by tetrahydrofolic acid and forms methylene-tetrahydrofolic acid. 4).to introduce carbon units at position 2 and 8 during de novo purine synthesis requires formyl-tetrahydrofolic acid and methenyl-tetrahydrofolic acid.5).generation and utilization of "formate pool". 6).For mediating formino group transfer in histidine metabolism. Folic acid is required to maintain normal erythropoiesis and nucleoprotein synthesis.Pharmacokinets of Folic AcidAbsorption: Well absorbed orally
Distribution: Widely distributed in the body and highest concentration is seen in liver. It appears in the CSF and breast milk
Metabolism: Metabolized in to N-methyl tetrahydrofolic acid in liver
Excretion: Extra drug is excreted unchanged in urine. A small portion of folate is lost by a combination of urinary and fecal excretion and oxidative cleavage of molecule.
Onset of Action for Folic AcidOral: 20 to 30minutes
I.V.: 5 minutes
I.M.:10 to 20minutes
Duration of Action for Folic AcidOral: 3 to 6 hours
I.V.:3 to 6minutes
I.M.:3 to 6hours
Half Life of Folic AcidN/ASide Effects of Folic AcidN/AContra-indications of Folic AcidN/ASpecial Precautions while taking Folic Acid1. In patients with undiagnosed anaemia; because it may mask pernicious anaemia
2. In pernicious anaemia and other megaloblastic where vitamin B12 is deficient
Pregnancy Related InformationMay be usedOld Age Related InformationMay be usedBreast Feeding Related InformationMay be usedChildren Related InformationMay be usedIndications for Folic Acid1. Megaloblastic anaemia
2. Folic acid deficiency
3. Anaemias of pregnancy
4. Nutritional anaemia
5. Alcoholism
6. Tropical sprue
7. Non tropical sprue
Interactions for Folic Acid1. Hypersensitivity reactions with injection form
2. Bronchospasm
Typical Dosage for Folic AcidOral: 5mg 1 to 4 times daily; depending up on the severity of deficiency.
Maintenance dosage: Half of the therapeutic dosage.
Children: 2.5 to 5mg 1 to 2 times daily.
Schedule of Folic AcidC1 (Oral)
C (Parenteral)
Storage Requirements for Folic AcidStore at controlled room temperature at a range of 15 to 25 degree C in a well closed container. Protect from excess heat, light and moisture.Effects of Missed Dosage of Folic AcidTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Folic AcidRelatively non toxic. Provide symptomatic treatment and supportive measures.Vitamin C
About Vitamin CWater soluble vitamin, antioxidant.Mechanism of Action of Vitamin CVitamin C exerts it`s action by influencing the biologic oxidations and reductions used in cellular respirations. It directly stimulates collagen synthesis and maintains intracellular connective tissue. It involves in various metabolic reactions such as 1).Hydroxylation of praline and lysine residues of protocollagen which is essential for formation and stabilization of collagen triple helix, 2).hydroxylation of carnitine, 3).Conversion of folic acid to folinic acid, 4).biosynthesis of adrenal steroids, catecholamines, oxytocin, and ADH, 5).Metabolism of cyclic nucleotides and prostaglandins. Vitamin C is important in resistance to infections.Pharmacokinets of Vitamin CAbsorption: Well absorbed orally.
Distribution: Widely distributed both extracellularly and intracellularly, It crosses the placenta and also distributed in to the breast milk.
Metabolism: Metabolized in the liver; partly oxidized in to active dehydroascorbic acid and inactive metabolites.
Excretion: Inactive metabolites and extra drug is excreted through urine.
Onset of Action for Vitamin CN/ADuration of Action for Vitamin CN/AHalf Life of Vitamin CN/ASide Effects of Vitamin C1. Discomfort at injection site
2. Acid urine
3. Renal calculi
4. Oxaluria
Contra-indications of Vitamin CNo known contraindicationsSpecial Precautions while taking Vitamin C1. Renal impairment
2. Ingestion of large doses during pregnancy has resulted in scurvy in neonates
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationMay be usedIndications for Vitamin C1. Scurvy
2. Prophylaxis and treatment of vitamin C deficiency
3. As an antioxidant to maintain natural colour and flavour of food items
4. For acidification of urine
5. Capillary fragility
6. Dental caries
Interactions for Vitamin COral contraceptives and estrogens: Vitamin C increases serum levels of oestrogen resulting in adverse reactions .
Warfarin: The anticoagulant effects of warfarin is reduced.
Lab Tests: Large doses (>500 mg) of vitamin C may cause false negative urine glucose determinations. May result in false negative amine dependent stool occult blood tests.Typical Dosage for Vitamin COral:
Adults: 50 to 1000mg/day depending up on the requirement.
Pregnancy and lactation: 100 to 150mg/day
Children: 30 to 100mg/day.
Scurvy:
Oral:
Adults: 1000mg twice daily to thrice daily.
Children: 300mg to 1000mg daily.
Sub clinical scurvy:
Oral, S.C., I.M., or I.V.: 100 to 250mg once daily or twice daily depending up on the severity of the condition. Then give a maintenance dosage of 50mg/day.
Children: 100 to 300mg depending up on the severity. Then give a maintenance dose of 35mg/day.
Schedule of Vitamin CC1 (Oral)
C (Parenteral)Storage Requirements for Vitamin CStore in a cool dry area in a well closed container. Protects from moisture, light and direct heat.Effects of Missed Dosage of Vitamin CTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Vitamin CDiscontinue the therapy and provide symptomatic and supportive measures.Dioctyl Sodium Sulphosuccinate
About Dioctyl Sodium SulphosuccinateAnionic surface-active agent,Stool Softener, Emollient Laxative, Ceruminolytic.Mechanism of Action of Dioctyl Sodium SulphosuccinateDioctyl sodium sulfosuccinate is an emollient laxative. It is an anionic detergent that increases the miscibility of water and thereby enhancing lipid absorption and impairing water absorption. It reduces surface tension and it has no role in peristalsis but it promotes softening of faeces.
It increases mucosal cyclic AMP mediated active anion secretion and produces increased accumulation of luminal fluid and produces defecation.
Pharmacokinets of Dioctyl Sodium SulphosuccinateN/AOnset of Action for Dioctyl Sodium Sulphosuccinate1 - 2 daysDuration of Action for Dioctyl Sodium SulphosuccinateN/AHalf Life of Dioctyl Sodium SulphosuccinateN/ASide Effects of Dioctyl Sodium Sulphosuccinate1.Diarrhoea
2.Nausea
3.Abdominal cramps
4.Skin rash
Contra-indications of Dioctyl Sodium Sulphosuccinate1.Hypersensitivity to the drug
Special Precautions while taking Dioctyl Sodium Sulphosuccinate1.Prolonged use of this medicine
2.People with nausea, vomiting or persistant abdominal pain.
3.People with a blockage in the gut (intestinal obstruction).
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with caution
Below 12 years: ContraindicatedIndications for Dioctyl Sodium Sulphosuccinate1.Chronic constipation.
2.Softening stools in people with haemorrhoids (piles) or anal fissure
Interactions for Dioctyl Sodium SulphosuccinateN/ATypical Dosage for Dioctyl Sodium Sulphosuccinate100 - 200 mg 3 times a day Schedule of Dioctyl Sodium SulphosuccinateN/AStorage Requirements for Dioctyl Sodium SulphosuccinateStore at 15 - 30 degree C. Protect from heat and light. Kept the container tightly closed after use. Keep out of the reach of childrenEffects of Missed Dosage of Dioctyl Sodium SulphosuccinateTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Dioctyl Sodium SulphosuccinateGive supportive measures and symptomatic treatment.Home Delivery for Iron (Ferrous gluconate) + Vit B12 + Vit B6 + Folic acid + Vitamin C + Dioctyl Sodium Sulphosuccinate in Your City
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Iron (Ferrous gluconate) + Vit B12 + Vit B6 + Folic acid + Vitamin C + Dioctyl Sodium Sulphosuccinate is a generic medicine name and there are several brands available for it. Some of the brands for iron (ferrous gluconate) + vit b12 + vit b6 + folic acid + vitamin c + dioctyl sodium sulphosuccinate might be better known than iron (ferrous gluconate) + vit b12 + vit b6 + folic acid + vitamin c + dioctyl sodium sulphosuccinate itself. If the pharmacy that's willing to deliver medicines to your home doesn't have iron (ferrous gluconate) + vit b12 + vit b6 + folic acid + vitamin c + dioctyl sodium sulphosuccinate in stock, you can ask for one of the branded alternatives for iron (ferrous gluconate) + vit b12 + vit b6 + folic acid + vitamin c + dioctyl sodium sulphosuccinate.