Iron (Carbonyl iron) + Vit B12 + Vit B6 + Folic acid + Vitamin C + Zinc Pharmacology

Iron (Carbonyl iron) + Vit B12 + Vit B6 + Folic acid + Vitamin C + Zinc

About Iron (Carbonyl iron) + Vit B12 + Vit B6 + Folic acid + Vitamin C + Zinc

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Mechanism of Action of Iron (Carbonyl iron) + Vit B12 + Vit B6 + Folic acid + Vitamin C + Zinc

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Pharmacokinets of Iron (Carbonyl iron) + Vit B12 + Vit B6 + Folic acid + Vitamin C + Zinc

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Onset of Action for Iron (Carbonyl iron) + Vit B12 + Vit B6 + Folic acid + Vitamin C + Zinc

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Duration of Action for Iron (Carbonyl iron) + Vit B12 + Vit B6 + Folic acid + Vitamin C + Zinc

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Half Life of Iron (Carbonyl iron) + Vit B12 + Vit B6 + Folic acid + Vitamin C + Zinc

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Side Effects of Iron (Carbonyl iron) + Vit B12 + Vit B6 + Folic acid + Vitamin C + Zinc

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Contra-indications of Iron (Carbonyl iron) + Vit B12 + Vit B6 + Folic acid + Vitamin C + Zinc

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Special Precautions while taking Iron (Carbonyl iron) + Vit B12 + Vit B6 + Folic acid + Vitamin C + Zinc

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Pregnancy Related Information

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Old Age Related Information

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Breast Feeding Related Information

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Children Related Information

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Indications for Iron (Carbonyl iron) + Vit B12 + Vit B6 + Folic acid + Vitamin C + Zinc

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Interactions for Iron (Carbonyl iron) + Vit B12 + Vit B6 + Folic acid + Vitamin C + Zinc

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Typical Dosage for Iron (Carbonyl iron) + Vit B12 + Vit B6 + Folic acid + Vitamin C + Zinc

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Schedule of Iron (Carbonyl iron) + Vit B12 + Vit B6 + Folic acid + Vitamin C + Zinc

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Storage Requirements for Iron (Carbonyl iron) + Vit B12 + Vit B6 + Folic acid + Vitamin C + Zinc

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Effects of Missed Dosage of Iron (Carbonyl iron) + Vit B12 + Vit B6 + Folic acid + Vitamin C + Zinc

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Effects of Overdose of Iron (Carbonyl iron) + Vit B12 + Vit B6 + Folic acid + Vitamin C + Zinc

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Iron (Carbonyl Iron)

About Iron (Carbonyl Iron)

A highly pure, nontoxic Iron(a minimum 98% iron content), Iron dietary supplement and to treat iron deficiency.

Mechanism of Action of Iron (Carbonyl Iron)

Iron formulations exerts haematinic action by being an essential constituent of haemoglobin. It is necessary for the oxidative process of living tissues.

Pharmacokinets of Iron (Carbonyl Iron)

Absorption: Absorbed orally in ferrous form and poorly absorbed in healthy individuals (about 10%) but in patients suffering from iron deficiency anaemia up to 60% dose is absorbed.
Distribution: Transported in a transferrin bound form in to bone marrow for incorporation in to haemoglobin.
Metabolism: Iron liberated by destruction of haemoglobin is reused by the body.
Excretion: Excretion of iron is minimal. Loss usually occurs in nails, faeces, urine, hair, sweat, and bile.

Onset of Action for Iron (Carbonyl Iron)

4 days

Duration of Action for Iron (Carbonyl Iron)

2 to 4 months

Half Life of Iron (Carbonyl Iron)

N/A

Side Effects of Iron (Carbonyl Iron)

1. Nausea
2. Epigasttric distress
3. Vomiting
4. Constipation
5. Diarrhoea
6. Black stools
7. Temporary staining of teeth with liquid formulations

Contra-indications of Iron (Carbonyl Iron)

1. Haemolytic anaemia unless iron deficiency anaemia is also present
2. Haemochromatosis
3. Haemosiderosis
4. Peptic ulcer
5. Regional enteritis
6. Ulcerative colitis
7. Those receiving repeated blood transfusions

Special Precautions while taking Iron (Carbonyl Iron)

1. Prolonged use
2. Minimise gastrointestinal discomfort by taking along with meals and gradually increasing the recommended dosage
3. Discontinue if intolerance occurs
4. Higher doses are required for geriatric patients

Pregnancy Related Information

May be used

Old Age Related Information

Use with caution

Breast Feeding Related Information

May be used

Children Related Information

Use with caution

Indications for Iron (Carbonyl Iron)

1. Iron deficiency
2. Iron deficiency during pregnancy and lactation
3. Iron deficiency in infants and children

Interactions for Iron (Carbonyl Iron)

(Oral Iron): Antacids: GI absorption of iron reduced.
Ascorbic acid: GI absorption of iron enhanced.
Chloramphenicol: Serum iron levels may be increased.
Cimetidine: GI absorption may be reduced.
Levodopa: Decreased levodopa serum levels.
Methyldopa: May result in decreased efficacy of methyldopa.
Quinolones: GI absorption of quinolones decreased.
Penicillamine: Marked reduction in GI absorption of penicillamine.
Tetracyclines: Decrease in the absorption of both tetracyclines and iron salts.
Food: Eggs and milk inhibit iron absorption. Administration of calcium and iron supplementation with food reduces ferrous sulfate absorption by one-third. If combined iron and calcium supplementation required then calcium carbonate should be used and the supplementation taken between meals.

Typical Dosage for Iron (Carbonyl Iron)

Oral:
Ferrous fumarate:
Adults: Starts with 50 to 100mg 2 to 3 times daily. Adjust the dosage based on patient`s response.
Children: 4 to 6mg/kg daily in three divided doses.
Ferrous sulphate:
Adults: 100 to 300mg; twice daily. Increases the dosage based on patient`s response if required up to 300mg 4 times daily.
Children (age 2 to 12): 3mg/kg/day in three to four divided doses
Children (age 6months to 2years): 3 to 6mg/kg/day in three to four divided doses
Infants: 10 to 25mg/day in three to four divided doses.
Ferrous gluconate:
300 to 1200mg daily in three to four divided doses.
Children (age 2 to 12): 3mg/kg/day in three to four divided doses
Children (age 6months to 2years): 3 to 6mg/kg/day in three to four divided doses
Infants: 10 to 25mg/day in three to four divided doses.

Schedule of Iron (Carbonyl Iron)

Storage Requirements for Iron (Carbonyl Iron)

Store in a well closed container in a cool dry place. Protect from light.

Effects of Missed Dosage of Iron (Carbonyl Iron)

Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.

Effects of Overdose of Iron (Carbonyl Iron)

Treatment includes immediate support of airway, respiration, and circulation. In conscious patients induce emesis with ipecac; if not empty stomach by gastric lavage. Follow emesis with lavage, using a 1% sodium bicarbonate solution to convert iron to less irritating poorly absorbed form. Take abdominal X-ray to determine presence of excess iron. Deferoxamine may be used for systemic chelation if serum levels of iron exceed 350mg/dl.

Vit B12

About Vit B12

N/A

Mechanism of Action of Vit B12

Vitamin B12 is an essential constituent for growth, cell reproduction, hematopoiesis, and nucleoprotein and myelin synthesis. Vitamin B12 is converted in to coenzyme B12 in the tissues which is essential for conversion of methyl-malonate to succinate and synthesis of methionine from homocystine. It is also associated with fat and carbohydrate metabolism and protein synthesis. Cells characterized by rapid division such as epithelial cells, bone marrow, and myeloid cells appear to have greatest requirement of Cyanocobalamin.

Pharmacokinets of Vit B12

Absorption: Absorbed irregularly after oral administration and absorption depends on Ca and intrinsic factor. It is also administered subcutaneously and intramuscularly.
Distribution: Distributed in to liver, bone marrow, and other tissues. It crosses the placenta and appears in breast milk.
Metabolism: It is metabolized in liver.
Excretion: In normal dosage it is reabsorbed from bile and a minute portion is excreted through urine but the extra drug is excreted through urine.

Onset of Action for Vit B12

N/A

Duration of Action for Vit B12

N/A

Half Life of Vit B12

N/A

Side Effects of Vit B12

1. Anaphylaxis
2. Anaphylactoid reactions
3. Pain and burning sensation at injection site
4. Itching
5. Urticaria
6. Transient diarrhea
7. Peripheral vascular thrombosis
8. Pulmonary oedema

Contra-indications of Vit B12

1. Hypersensitivity to the drug
2. Leber`s disease

Special Precautions while taking Vit B12

1. Anemic patients with coexisting cardiac, pulmonary and hypertensive diseases.

Pregnancy Related Information

May be used

Old Age Related Information

May be used

Breast Feeding Related Information

May be used

Children Related Information

Use with caution
NEONATES : Use with caution

Indications for Vit B12

1. Vitamin B12 deficiency
2. Pernicious Anaemia
3. Peripheral neuropathy (diabetic, alcoholic, and drug induced)

Interactions for Vit B12

N/A

Typical Dosage for Vit B12

I.M., S.C.:
Pernicious Anaemia: 100mcg daily for 1 week followed by the same dose given on alternate days for 7 doses and then every 3 to 4days for another 3 weeks. This regimen should be followed by 100mcg monthly for life. Concurrently administer folic acid if required.
Vitamin B12 deficiency other than pernicious Anaemia: 30mcg daily for 5 to 10days depending up on the severity of the condition.
Maintenance dosage: 100 to 200mcg once monthly.
Children: 100mcg I.M. or S.C. over the course of 2 or more weeks.
Maintenance dosage: 60mcg monthly I.M. or S.C.
Schilling test flushing dose:
Adults and Children: 1000mcg I.M. in single dose
Recommended RDA (recommended dietary allowance) for Vitamin B12:
Infants up to 6months of age: 0.3mcg.
Children age 6 months to 1 year: 0.5mcg.
Children age 1 to 3: 0.7mcg.
Children age 4 to 6: 1mcg.
Children age 7 to 10: 1.4mcg.
Children age 11 to adult: 2mcg..
Pregnant women: 2.2mcg.
Breast feeding women: 2.6mcg.

Schedule of Vit B12

Storage Requirements for Vit B12

Store at room temperature range of 15 to 30 degree C.in a light resistant well closed container in a dry place.

Effects of Missed Dosage of Vit B12

Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.

Effects of Overdose of Vit B12

Not applicable. Even in large doses Vitamin B12 isn`t usually toxic.

Vit B6

About Vit B6

Physiological functions: It is involved as a coenzyme (Pyridoxal phosphate) in metabolism of tryptophan, in several metabolic transformations of amino acids including transamination, decarboxylation & racemization.
Deficiency symptoms: Peripheral neuritis, seizures, stomatitis, glossitis, anaemia, seborrhea like lesions.

Mechanism of Action of Vit B6

Vitamin B6 is a collective term for Pyridoxine, Pyridoxal, Pyridoxamine and their phosphorylated derivatives such as Pyridoxine phosphate, Pyridoxal phosphate and Pyridoxamine derivatives respectively. Vitamin B6 is essential for the metabolism of amino acid, glycogen and fatty acids, for nerve functions, for the formation of red blood cells and also helps the skin healthy. Vitamin B6 is also used for the synthesis of nucleic acid, Haemoglobin, Sphingomyelin, other Sphingolipids, Serotonin, Dopamine, Noradrenaline and GABA.

Pharmacokinets of Vit B6

Absorption: Vitamin B6 is readily absorbed after oral administration.
Distribution: It is mainly distributed in the body in protein bound form. It is stored primarily in the liver and to a lesser extent muscle and brain.
Metabolism: It is metabolised in the liver

Onset of Action for Vit B6

N/A

Duration of Action for Vit B6

N/A

Half Life of Vit B6

15-20 days

Side Effects of Vit B6

1. Neuropathy
2. Unstable gait
3. Drowsiness
4. Perioral numbness
5. Paresthesia
6. Numbness of feet
7. Somnolence
8. Sensory neuropathy
9. Ataxia

Contra-indications of Vit B6

1. Hypersensitivity to Vitamin B6

Special Precautions while taking Vit B6

N/A

Pregnancy Related Information

May be used

Old Age Related Information

May be used

Breast Feeding Related Information

Use with caution

Children Related Information

Use with caution
NEONATES: Contraindicated

Indications for Vit B6

1. Vitamin B6 deficiency including inadequate diet and drug induced causes
2. Neuropathy
3. Premenstrual syndrome
4. Hyperoxaluria type 1
5. Metabolic disorder
6. Isoniazid poisoning

Interactions for Vit B6

Cycloserine, Hydralazine, Isoniazide, Oral contraceptive, Penicillamine: Increase Pyridoxine requirement.
Levodopa: Pyridoxine reverses the therapeutic effect of Levodopa.
Phenobarbital, Phenytoin: Pyridoxine decreases serum level of these anticonvulsants.

Typical Dosage for Vit B6

Adult: 10 - 20 mg / day
Dietary deficiency: 2.5 -10 mg / day for effective therapeutic response is obtained.
Maintenance dose: 2 - 5 mg / day for several weeks.
Drug induced deficiency: 100 - 200 mg / day for 3 weeks.
Maintenance dose: 25 - 100 mg / day
Neuropathy: 50 - 200 mg /day
Premenstrual syndrome: 40 - 500 mg / day
Hyperoxaluria type 1: 25 - 300 mg / day
Metabolic disorder: 100-500 mg /day.
Isoniazid poisoning: Initial dose: 1 - 4 g as IV administration, then 1 g IM every 30 minute until Pyridoxine dose is equal to the Isoniazid dose has been given.

Schedule of Vit B6

N/A

Storage Requirements for Vit B6

Store it at 15 - 30 degree C. Protect from moisture and heat.

Effects of Missed Dosage of Vit B6

Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.

Effects of Overdose of Vit B6

Give supportive measures and symptomatic treatment. The signs of Pyridoxine overdose can be resolved by discontinuation (withdrawal) of Pyridoxine.

Folic Acid

About Folic Acid

Dietary supplement, Folate derivative( B9 ), Water Soluble Vitamin.

Mechanism of Action of Folic Acid

Folic acid reduced by enzymes folate reductase and dihydrofolate reductase and forms dihydrofolic acid tetrahydrofolic acid respectively. Tetrahydrofolic acid acts as a coenzyme which mediates a number of one carbon transfer reactions by carrying a methyl group as an adduct. It involves a number of reactions such as 1).conversion of homocysteine to methionine. 2).synthesis of thymidylate which is an essential constituent of DNA from methylene-tetrahydrofolic acid. 3). Conversion of serine to glycine by tetrahydrofolic acid and forms methylene-tetrahydrofolic acid. 4).to introduce carbon units at position 2 and 8 during de novo purine synthesis requires formyl-tetrahydrofolic acid and methenyl-tetrahydrofolic acid.5).generation and utilization of "formate pool". 6).For mediating formino group transfer in histidine metabolism. Folic acid is required to maintain normal erythropoiesis and nucleoprotein synthesis.

Pharmacokinets of Folic Acid

Absorption: Well absorbed orally
Distribution: Widely distributed in the body and highest concentration is seen in liver. It appears in the CSF and breast milk
Metabolism: Metabolized in to N-methyl tetrahydrofolic acid in liver
Excretion: Extra drug is excreted unchanged in urine. A small portion of folate is lost by a combination of urinary and fecal excretion and oxidative cleavage of molecule.

Onset of Action for Folic Acid

Oral: 20 to 30minutes
I.V.: 5 minutes
I.M.:10 to 20minutes

Duration of Action for Folic Acid

Oral: 3 to 6 hours
I.V.:3 to 6minutes
I.M.:3 to 6hours

Half Life of Folic Acid

N/A

Side Effects of Folic Acid

N/A

Contra-indications of Folic Acid

N/A

Special Precautions while taking Folic Acid

1. In patients with undiagnosed anaemia; because it may mask pernicious anaemia
2. In pernicious anaemia and other megaloblastic where vitamin B12 is deficient

Pregnancy Related Information

May be used

Old Age Related Information

May be used

Breast Feeding Related Information

May be used

Children Related Information

May be used

Indications for Folic Acid

1. Megaloblastic anaemia
2. Folic acid deficiency
3. Anaemias of pregnancy
4. Nutritional anaemia
5. Alcoholism
6. Tropical sprue
7. Non tropical sprue

Interactions for Folic Acid

1. Hypersensitivity reactions with injection form
2. Bronchospasm

Typical Dosage for Folic Acid

Oral: 5mg 1 to 4 times daily; depending up on the severity of deficiency.
Maintenance dosage: Half of the therapeutic dosage.
Children: 2.5 to 5mg 1 to 2 times daily.

Schedule of Folic Acid

C1 (Oral)
C (Parenteral)

Storage Requirements for Folic Acid

Store at controlled room temperature at a range of 15 to 25 degree C in a well closed container. Protect from excess heat, light and moisture.

Effects of Missed Dosage of Folic Acid

Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.

Effects of Overdose of Folic Acid

Relatively non toxic. Provide symptomatic treatment and supportive measures.

Vitamin C

About Vitamin C

Water soluble vitamin, antioxidant.

Mechanism of Action of Vitamin C

Vitamin C exerts it`s action by influencing the biologic oxidations and reductions used in cellular respirations. It directly stimulates collagen synthesis and maintains intracellular connective tissue. It involves in various metabolic reactions such as 1).Hydroxylation of praline and lysine residues of protocollagen which is essential for formation and stabilization of collagen triple helix, 2).hydroxylation of carnitine, 3).Conversion of folic acid to folinic acid, 4).biosynthesis of adrenal steroids, catecholamines, oxytocin, and ADH, 5).Metabolism of cyclic nucleotides and prostaglandins. Vitamin C is important in resistance to infections.

Pharmacokinets of Vitamin C

Absorption: Well absorbed orally.
Distribution: Widely distributed both extracellularly and intracellularly, It crosses the placenta and also distributed in to the breast milk.
Metabolism: Metabolized in the liver; partly oxidized in to active dehydroascorbic acid and inactive metabolites.
Excretion: Inactive metabolites and extra drug is excreted through urine.

Onset of Action for Vitamin C

N/A

Duration of Action for Vitamin C

N/A

Half Life of Vitamin C

N/A

Side Effects of Vitamin C

1. Discomfort at injection site
2. Acid urine
3. Renal calculi
4. Oxaluria

Contra-indications of Vitamin C

No known contraindications

Special Precautions while taking Vitamin C

1. Renal impairment
2. Ingestion of large doses during pregnancy has resulted in scurvy in neonates

Pregnancy Related Information

Use with caution

Old Age Related Information

Use with caution

Breast Feeding Related Information

Use with caution

Children Related Information

May be used

Indications for Vitamin C

1. Scurvy
2. Prophylaxis and treatment of vitamin C deficiency
3. As an antioxidant to maintain natural colour and flavour of food items
4. For acidification of urine
5. Capillary fragility
6. Dental caries

Interactions for Vitamin C

Oral contraceptives and estrogens: Vitamin C increases serum levels of oestrogen resulting in adverse reactions .
Warfarin: The anticoagulant effects of warfarin is reduced.
Lab Tests: Large doses (>500 mg) of vitamin C may cause false negative urine glucose determinations. May result in false negative amine dependent stool occult blood tests.

Typical Dosage for Vitamin C

Oral:
Adults: 50 to 1000mg/day depending up on the requirement.
Pregnancy and lactation: 100 to 150mg/day
Children: 30 to 100mg/day.
Scurvy:
Oral:
Adults: 1000mg twice daily to thrice daily.
Children: 300mg to 1000mg daily.
Sub clinical scurvy:
Oral, S.C., I.M., or I.V.: 100 to 250mg once daily or twice daily depending up on the severity of the condition. Then give a maintenance dosage of 50mg/day.
Children: 100 to 300mg depending up on the severity. Then give a maintenance dose of 35mg/day.

Schedule of Vitamin C

C1 (Oral)
C (Parenteral)

Storage Requirements for Vitamin C

Store in a cool dry area in a well closed container. Protects from moisture, light and direct heat.

Effects of Missed Dosage of Vitamin C

Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.

Effects of Overdose of Vitamin C

Discontinue the therapy and provide symptomatic and supportive measures.

Zinc

About Zinc

Trance metal, Dietary mineral, Nutritional supplement,Treatment of zinc deficiency,in wound healing.

Mechanism of Action of Zinc

Zinc acts as a cofactor for more than 70 different enzymes. Zinc dependent enzymes are involved in the metabolism of carbohydrates, lipids, and proteins. Zinc facilitates wound healing, normal growth rates, normal skin hydration and maintains senses of taste and smell. It provides normal growth and tissue repair. It also helps in development of cell mediated immunity.

Pharmacokinets of Zinc

Absorption: Poorly absorbed orally, Distribution: Zinc is distributed mainly in to skeletal muscle, skin, bone, pancreas, kidney, liver, retina, prostate, RBC, and WBC. Excretion: Excreted mainly through intestine; only 2% loss in the urine.

Onset of Action for Zinc

N/A

Duration of Action for Zinc

N/A

Half Life of Zinc

N/A

Side Effects of Zinc

1. Nausea
2. Vomiting
3. Abdominal distress
4. Gastric ulceration
5. Rashes

Contra-indications of Zinc

N/A

Special Precautions while taking Zinc

1.Don`t exceed prescribed dose
2.Renal failure
3.Biliary obstruction

Pregnancy Related Information

Use with caution

Old Age Related Information

N/A

Breast Feeding Related Information

N/A

Children Related Information

N/A

Indications for Zinc

1. Zinc deficiency
2. Acne vulgaris
3. Chronic skin ulcers
4. Adjunct to antimicrobials
5. Delayed wound healing
6. Alopecia

Interactions for Zinc

Fluoroquinolones, Tetracyclines: Decreased GI absorption and serum levels of some fluoroquinolone.
Pencillamine: Reduced absorption of zinc.
Iron: Reduced absorption of iron and vice versa.

Typical Dosage for Zinc

Adults: 25 to 50mg zinc daily or 1 to 2 tablets daily.
Children: 5mg/kg 1 to 3 times daily.

Schedule of Zinc

N/A

Storage Requirements for Zinc

Store at a temperature below 30 degree C

Effects of Missed Dosage of Zinc

Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.

Effects of Overdose of Zinc

Provide symptomatic treatment and supportive measures

Home Delivery for Iron (Carbonyl iron) + Vit B12 + Vit B6 + Folic acid + Vitamin C + Zinc in Your City

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Iron (Carbonyl iron) + Vit B12 + Vit B6 + Folic acid + Vitamin C + Zinc is a generic medicine name and there are several brands available for it. Some of the brands for iron (carbonyl iron) + vit b12 + vit b6 + folic acid + vitamin c + zinc might be better known than iron (carbonyl iron) + vit b12 + vit b6 + folic acid + vitamin c + zinc itself. If the pharmacy that's willing to deliver medicines to your home doesn't have iron (carbonyl iron) + vit b12 + vit b6 + folic acid + vitamin c + zinc in stock, you can ask for one of the branded alternatives for iron (carbonyl iron) + vit b12 + vit b6 + folic acid + vitamin c + zinc.