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- Pharmacology For Iron (Ferrous fumarate) + Folic acid + Dioctyl Sodium Sulphosuccinate
Iron (Ferrous fumarate) + Folic acid + Dioctyl Sodium Sulphosuccinate Pharmacology
Iron (Ferrous fumarate) + Folic acid + Dioctyl Sodium Sulphosuccinate
About Iron (Ferrous fumarate) + Folic acid + Dioctyl Sodium SulphosuccinateN/AMechanism of Action of Iron (Ferrous fumarate) + Folic acid + Dioctyl Sodium SulphosuccinateN/APharmacokinets of Iron (Ferrous fumarate) + Folic acid + Dioctyl Sodium SulphosuccinateN/AOnset of Action for Iron (Ferrous fumarate) + Folic acid + Dioctyl Sodium SulphosuccinateN/ADuration of Action for Iron (Ferrous fumarate) + Folic acid + Dioctyl Sodium SulphosuccinateN/AHalf Life of Iron (Ferrous fumarate) + Folic acid + Dioctyl Sodium SulphosuccinateN/ASide Effects of Iron (Ferrous fumarate) + Folic acid + Dioctyl Sodium SulphosuccinateN/AContra-indications of Iron (Ferrous fumarate) + Folic acid + Dioctyl Sodium SulphosuccinateN/ASpecial Precautions while taking Iron (Ferrous fumarate) + Folic acid + Dioctyl Sodium SulphosuccinateN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Iron (Ferrous fumarate) + Folic acid + Dioctyl Sodium SulphosuccinateN/AInteractions for Iron (Ferrous fumarate) + Folic acid + Dioctyl Sodium SulphosuccinateN/ATypical Dosage for Iron (Ferrous fumarate) + Folic acid + Dioctyl Sodium SulphosuccinateN/ASchedule of Iron (Ferrous fumarate) + Folic acid + Dioctyl Sodium SulphosuccinateN/AStorage Requirements for Iron (Ferrous fumarate) + Folic acid + Dioctyl Sodium SulphosuccinateN/AEffects of Missed Dosage of Iron (Ferrous fumarate) + Folic acid + Dioctyl Sodium SulphosuccinateN/AEffects of Overdose of Iron (Ferrous fumarate) + Folic acid + Dioctyl Sodium SulphosuccinateN/AIron (Ferrous fumarate)
About Iron (Ferrous fumarate)Iron (II) salt of fumaric acid, Oral iron preparation, Antianemic,hematinic.Mechanism of Action of Iron (Ferrous fumarate)Ferrous fumarate is used as a source of iron for iron-deficiency anaemia. It is given by mouth in usual doses of up to 600 mg daily (equivalent to about 200 mg of iron daily). Iron formulations exert haematinic action by being an essential constituent of haemoglobin. It is necessary for the oxidative process of living tissues.
Ferrous fumarate has similar efficacy as that of Ferrous sulphate.But it is more stable and almost tasteless as compared to Ferrous fumarate and it does not precipitate proteins and does not interfere with enzymes of digestive system.
Pharmacokinets of Iron (Ferrous fumarate)Absorption: Absorbed orally in ferrous form and poorly absorbed in healthy individuals (about 10%) but in patients suffering from iron deficiency anaemia up to 60% dose is absorbed. Distribution: Transported in a transferrin bound form in to bone marrow for incorporation in to haemoglobin. Metabolism: Iron liberated by destruction of haemoglobin is reused by the body. Excretion: Excretion of iron is minimal. Loss usually occurs in nails, faeces, urine, hair, sweat, and bile.
Onset of Action for Iron (Ferrous fumarate)N/ADuration of Action for Iron (Ferrous fumarate)N/AHalf Life of Iron (Ferrous fumarate)N/ASide Effects of Iron (Ferrous fumarate)1.Nausea
2.Epigasttric distress
3.Vomiting
4.Constipation
5.Diarrhoea
6.Black stools
7.Temporary staining of teeth with liquid formulations.
Contra-indications of Iron (Ferrous fumarate)1.Haemolytic anaemia unless iron deficiency anaemia is also present
2.Haemochromatosis
3.Haemosiderosis
4.Peptic ulcer
5.Regional enteritis
6.Ulcerative colitis
7.Those receiving repeated blood transfusions
Special Precautions while taking Iron (Ferrous fumarate)1. Prolonged use
2. Minimise gastrointestinal discomfort by taking along with meals and gradually increasing the recommended dosage
3. Discontinue if intolerance occurs
4. Higher doses are required for geriatric patients
Pregnancy Related InformationMay be usedOld Age Related InformationUse with cautionBreast Feeding Related InformationMay be usedChildren Related InformationUse with cautionIndications for Iron (Ferrous fumarate)1. Iron deficiency
2. Iron deficiency anaemiaInteractions for Iron (Ferrous fumarate)N/ATypical Dosage for Iron (Ferrous fumarate)Oral:
Adults: Starts with 50 to 100mg 2 to 3 times daily. Adjust the dosage based on patient`s response.
Children: 4 to 6mg/kg daily in three divided doses.
Schedule of Iron (Ferrous fumarate)HStorage Requirements for Iron (Ferrous fumarate)Store in a well closed container in a cool dry place. Protect from light.Effects of Missed Dosage of Iron (Ferrous fumarate)Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Iron (Ferrous fumarate)Treatment includes immediate support of airway, respiration, and circulation. In conscious patients induce emesis with ipecac; if not empty stomach by gastric lavage. Follow emesis with lavage, using a 1% sodium bicarbonate solution to convert iron to less irritating poorly absorbed form. Take abdominal X-ray to determine presence of excess iron. Deferoxamine may be used for systemic chelation if serum levels of iron exceed 350mg/dl. Folic Acid
About Folic AcidDietary supplement, Folate derivative( B9 ), Water Soluble Vitamin.Mechanism of Action of Folic AcidFolic acid reduced by enzymes folate reductase and dihydrofolate reductase and forms dihydrofolic acid tetrahydrofolic acid respectively. Tetrahydrofolic acid acts as a coenzyme which mediates a number of one carbon transfer reactions by carrying a methyl group as an adduct. It involves a number of reactions such as 1).conversion of homocysteine to methionine. 2).synthesis of thymidylate which is an essential constituent of DNA from methylene-tetrahydrofolic acid. 3). Conversion of serine to glycine by tetrahydrofolic acid and forms methylene-tetrahydrofolic acid. 4).to introduce carbon units at position 2 and 8 during de novo purine synthesis requires formyl-tetrahydrofolic acid and methenyl-tetrahydrofolic acid.5).generation and utilization of "formate pool". 6).For mediating formino group transfer in histidine metabolism. Folic acid is required to maintain normal erythropoiesis and nucleoprotein synthesis.Pharmacokinets of Folic AcidAbsorption: Well absorbed orally
Distribution: Widely distributed in the body and highest concentration is seen in liver. It appears in the CSF and breast milk
Metabolism: Metabolized in to N-methyl tetrahydrofolic acid in liver
Excretion: Extra drug is excreted unchanged in urine. A small portion of folate is lost by a combination of urinary and fecal excretion and oxidative cleavage of molecule.
Onset of Action for Folic AcidOral: 20 to 30minutes
I.V.: 5 minutes
I.M.:10 to 20minutes
Duration of Action for Folic AcidOral: 3 to 6 hours
I.V.:3 to 6minutes
I.M.:3 to 6hours
Half Life of Folic AcidN/ASide Effects of Folic AcidN/AContra-indications of Folic AcidN/ASpecial Precautions while taking Folic Acid1. In patients with undiagnosed anaemia; because it may mask pernicious anaemia
2. In pernicious anaemia and other megaloblastic where vitamin B12 is deficient
Pregnancy Related InformationMay be usedOld Age Related InformationMay be usedBreast Feeding Related InformationMay be usedChildren Related InformationMay be usedIndications for Folic Acid1. Megaloblastic anaemia
2. Folic acid deficiency
3. Anaemias of pregnancy
4. Nutritional anaemia
5. Alcoholism
6. Tropical sprue
7. Non tropical sprue
Interactions for Folic Acid1. Hypersensitivity reactions with injection form
2. Bronchospasm
Typical Dosage for Folic AcidOral: 5mg 1 to 4 times daily; depending up on the severity of deficiency.
Maintenance dosage: Half of the therapeutic dosage.
Children: 2.5 to 5mg 1 to 2 times daily.
Schedule of Folic AcidC1 (Oral)
C (Parenteral)
Storage Requirements for Folic AcidStore at controlled room temperature at a range of 15 to 25 degree C in a well closed container. Protect from excess heat, light and moisture.Effects of Missed Dosage of Folic AcidTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Folic AcidRelatively non toxic. Provide symptomatic treatment and supportive measures.Dioctyl Sodium Sulphosuccinate
About Dioctyl Sodium SulphosuccinateAnionic surface-active agent,Stool Softener, Emollient Laxative, Ceruminolytic.Mechanism of Action of Dioctyl Sodium SulphosuccinateDioctyl sodium sulfosuccinate is an emollient laxative. It is an anionic detergent that increases the miscibility of water and thereby enhancing lipid absorption and impairing water absorption. It reduces surface tension and it has no role in peristalsis but it promotes softening of faeces.
It increases mucosal cyclic AMP mediated active anion secretion and produces increased accumulation of luminal fluid and produces defecation.
Pharmacokinets of Dioctyl Sodium SulphosuccinateN/AOnset of Action for Dioctyl Sodium Sulphosuccinate1 - 2 daysDuration of Action for Dioctyl Sodium SulphosuccinateN/AHalf Life of Dioctyl Sodium SulphosuccinateN/ASide Effects of Dioctyl Sodium Sulphosuccinate1.Diarrhoea
2.Nausea
3.Abdominal cramps
4.Skin rash
Contra-indications of Dioctyl Sodium Sulphosuccinate1.Hypersensitivity to the drug
Special Precautions while taking Dioctyl Sodium Sulphosuccinate1.Prolonged use of this medicine
2.People with nausea, vomiting or persistant abdominal pain.
3.People with a blockage in the gut (intestinal obstruction).
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with caution
Below 12 years: ContraindicatedIndications for Dioctyl Sodium Sulphosuccinate1.Chronic constipation.
2.Softening stools in people with haemorrhoids (piles) or anal fissure
Interactions for Dioctyl Sodium SulphosuccinateN/ATypical Dosage for Dioctyl Sodium Sulphosuccinate100 - 200 mg 3 times a day Schedule of Dioctyl Sodium SulphosuccinateN/AStorage Requirements for Dioctyl Sodium SulphosuccinateStore at 15 - 30 degree C. Protect from heat and light. Kept the container tightly closed after use. Keep out of the reach of childrenEffects of Missed Dosage of Dioctyl Sodium SulphosuccinateTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Dioctyl Sodium SulphosuccinateGive supportive measures and symptomatic treatment.Home Delivery for Iron (Ferrous fumarate) + Folic acid + Dioctyl Sodium Sulphosuccinate in Your City
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Iron (Ferrous fumarate) + Folic acid + Dioctyl Sodium Sulphosuccinate is a generic medicine name and there are several brands available for it. Some of the brands for iron (ferrous fumarate) + folic acid + dioctyl sodium sulphosuccinate might be better known than iron (ferrous fumarate) + folic acid + dioctyl sodium sulphosuccinate itself. If the pharmacy that's willing to deliver medicines to your home doesn't have iron (ferrous fumarate) + folic acid + dioctyl sodium sulphosuccinate in stock, you can ask for one of the branded alternatives for iron (ferrous fumarate) + folic acid + dioctyl sodium sulphosuccinate.