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- Pharmacology For Iron (Ferric ammonium citrate) + Vit B12 + Vit B6 + Vit B3 + Zinc
Iron (Ferric ammonium citrate) + Vit B12 + Vit B6 + Vit B3 + Zinc Pharmacology
Iron (Ferric ammonium citrate) + Vit B12 + Vit B6 + Vit B3 + Zinc
About Iron (Ferric ammonium citrate) + Vit B12 + Vit B6 + Vit B3 + ZincN/AMechanism of Action of Iron (Ferric ammonium citrate) + Vit B12 + Vit B6 + Vit B3 + ZincN/APharmacokinets of Iron (Ferric ammonium citrate) + Vit B12 + Vit B6 + Vit B3 + ZincN/AOnset of Action for Iron (Ferric ammonium citrate) + Vit B12 + Vit B6 + Vit B3 + ZincN/ADuration of Action for Iron (Ferric ammonium citrate) + Vit B12 + Vit B6 + Vit B3 + ZincN/AHalf Life of Iron (Ferric ammonium citrate) + Vit B12 + Vit B6 + Vit B3 + ZincN/ASide Effects of Iron (Ferric ammonium citrate) + Vit B12 + Vit B6 + Vit B3 + ZincN/AContra-indications of Iron (Ferric ammonium citrate) + Vit B12 + Vit B6 + Vit B3 + ZincN/ASpecial Precautions while taking Iron (Ferric ammonium citrate) + Vit B12 + Vit B6 + Vit B3 + ZincN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Iron (Ferric ammonium citrate) + Vit B12 + Vit B6 + Vit B3 + ZincN/AInteractions for Iron (Ferric ammonium citrate) + Vit B12 + Vit B6 + Vit B3 + ZincN/ATypical Dosage for Iron (Ferric ammonium citrate) + Vit B12 + Vit B6 + Vit B3 + ZincN/ASchedule of Iron (Ferric ammonium citrate) + Vit B12 + Vit B6 + Vit B3 + ZincN/AStorage Requirements for Iron (Ferric ammonium citrate) + Vit B12 + Vit B6 + Vit B3 + ZincN/AEffects of Missed Dosage of Iron (Ferric ammonium citrate) + Vit B12 + Vit B6 + Vit B3 + ZincN/AEffects of Overdose of Iron (Ferric ammonium citrate) + Vit B12 + Vit B6 + Vit B3 + ZincN/AIron (Ferric ammonium citrate)
About Iron (Ferric ammonium citrate)An iron-containing salt,oral iron preparation, Antianemic,hematinic.Mechanism of Action of Iron (Ferric ammonium citrate)Ferric Ammonium Citrate contains between 16.5% and 18.5% of iron. It exerts haematinic action by being an essential constituent of haemoglobin. It is necessary for the oxidative process of living tissues. Ferric ammonium citrate is given by mouth as a source of iron for iron-deficiency anaemia.Ferric salts have not been preferred over ferrous salts as the ferric ion first requires reduction to ferrous form in the intestinal lumen. The bio-availability of iron from ferric salts is 3 to 4 times less than that of ferrous form.Ferric ammonium citrate (18% elemental iron) is the most commonly used ferric salts.Pharmacokinets of Iron (Ferric ammonium citrate)Absorption: Ferric is converted into Ferrous form and it is absorbed in ferrous form. It is poorly absorbed in healthy individuals (about 10%) but in patients suffering from iron deficiency anaemia up to 60% dose is absorbed. Distribution: Transported in a transferrin bound form in to bone marrow for incorporation in to haemoglobin. Metabolism: Iron liberated by destruction of haemoglobin is reused by the body. Excretion: Excretion of iron is minimal. Loss usually occurs in nails, faeces, urine, hair, sweat, and bile.Onset of Action for Iron (Ferric ammonium citrate)N/ADuration of Action for Iron (Ferric ammonium citrate)N/AHalf Life of Iron (Ferric ammonium citrate)N/ASide Effects of Iron (Ferric ammonium citrate)1.Nausea
2.Epigasttric distress
3.Vomiting
4.Constipation
5.Diarrhoea
6.Black stools
7.Temporary staining of teeth with liquid formulations.
Contra-indications of Iron (Ferric ammonium citrate)1.Haemolytic anaemia unless iron deficiency anaemia is also present
2.Haemochromatosis
3.Haemosiderosis
4.Peptic ulcer
5.Regional enteritis
6.Ulcerative colitis
7.Those receiving repeated blood transfusions
Special Precautions while taking Iron (Ferric ammonium citrate)1. Prolonged use
2. Minimise gastrointestinal discomfort by taking along with meals and gradually increasing the recommended dosage
3. Discontinue if intolerance occurs
4. Higher doses are required for geriatric patients
Pregnancy Related InformationMay be usedOld Age Related InformationUse with cautionBreast Feeding Related InformationMay be usedChildren Related InformationUse with cautionIndications for Iron (Ferric ammonium citrate)1. Iron deficiency
2. Iron deficiency anaemia
Interactions for Iron (Ferric ammonium citrate)N/ATypical Dosage for Iron (Ferric ammonium citrate)Adult: I capsule or 15ml twice daily after meals.
Children: 5 ml twice daily after meals.
Schedule of Iron (Ferric ammonium citrate)HStorage Requirements for Iron (Ferric ammonium citrate)Store in a well closed container in a cool dry place. Protect from light.Effects of Missed Dosage of Iron (Ferric ammonium citrate)Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Iron (Ferric ammonium citrate)Treatment includes immediate support of airway, respiration, and circulation. In conscious patients induce emesis with ipecac; if not empty stomach by gastric lavage. Follow emesis with lavage, using a 1% sodium bicarbonate solution to convert iron to less irritating poorly absorbed form. Take abdominal X-ray to determine presence of excess iron. Deferoxamine may be used for systemic chelation if serum levels of iron exceed 350mg/dl. Vit B12
About Vit B12N/AMechanism of Action of Vit B12Vitamin B12 is an essential constituent for growth, cell reproduction, hematopoiesis, and nucleoprotein and myelin synthesis. Vitamin B12 is converted in to coenzyme B12 in the tissues which is essential for conversion of methyl-malonate to succinate and synthesis of methionine from homocystine. It is also associated with fat and carbohydrate metabolism and protein synthesis. Cells characterized by rapid division such as epithelial cells, bone marrow, and myeloid cells appear to have greatest requirement of Cyanocobalamin.Pharmacokinets of Vit B12Absorption: Absorbed irregularly after oral administration and absorption depends on Ca and intrinsic factor. It is also administered subcutaneously and intramuscularly.
Distribution: Distributed in to liver, bone marrow, and other tissues. It crosses the placenta and appears in breast milk.
Metabolism: It is metabolized in liver.
Excretion: In normal dosage it is reabsorbed from bile and a minute portion is excreted through urine but the extra drug is excreted through urine.
Onset of Action for Vit B12N/ADuration of Action for Vit B12N/AHalf Life of Vit B12N/ASide Effects of Vit B121. Anaphylaxis
2. Anaphylactoid reactions
3. Pain and burning sensation at injection site
4. Itching
5. Urticaria
6. Transient diarrhea
7. Peripheral vascular thrombosis
8. Pulmonary oedema
Contra-indications of Vit B121. Hypersensitivity to the drug
2. Leber`s disease
Special Precautions while taking Vit B121. Anemic patients with coexisting cardiac, pulmonary and hypertensive diseases.Pregnancy Related InformationMay be usedOld Age Related InformationMay be usedBreast Feeding Related InformationMay be usedChildren Related InformationUse with caution
NEONATES : Use with caution
Indications for Vit B121. Vitamin B12 deficiency
2. Pernicious Anaemia
3. Peripheral neuropathy (diabetic, alcoholic, and drug induced)
Interactions for Vit B12N/ATypical Dosage for Vit B12I.M., S.C.:
Pernicious Anaemia: 100mcg daily for 1 week followed by the same dose given on alternate days for 7 doses and then every 3 to 4days for another 3 weeks. This regimen should be followed by 100mcg monthly for life. Concurrently administer folic acid if required.
Vitamin B12 deficiency other than pernicious Anaemia: 30mcg daily for 5 to 10days depending up on the severity of the condition.
Maintenance dosage: 100 to 200mcg once monthly.
Children: 100mcg I.M. or S.C. over the course of 2 or more weeks.
Maintenance dosage: 60mcg monthly I.M. or S.C.
Schilling test flushing dose:
Adults and Children: 1000mcg I.M. in single dose
Recommended RDA (recommended dietary allowance) for Vitamin B12:
Infants up to 6months of age: 0.3mcg.
Children age 6 months to 1 year: 0.5mcg.
Children age 1 to 3: 0.7mcg.
Children age 4 to 6: 1mcg.
Children age 7 to 10: 1.4mcg.
Children age 11 to adult: 2mcg..
Pregnant women: 2.2mcg.
Breast feeding women: 2.6mcg.
Schedule of Vit B12CStorage Requirements for Vit B12Store at room temperature range of 15 to 30 degree C.in a light resistant well closed container in a dry place.Effects of Missed Dosage of Vit B12Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Vit B12Not applicable. Even in large doses Vitamin B12 isn`t usually toxic.Vit B6
About Vit B6Physiological functions: It is involved as a coenzyme (Pyridoxal phosphate) in metabolism of tryptophan, in several metabolic transformations of amino acids including transamination, decarboxylation & racemization.
Deficiency symptoms: Peripheral neuritis, seizures, stomatitis, glossitis, anaemia, seborrhea like lesions.Mechanism of Action of Vit B6Vitamin B6 is a collective term for Pyridoxine, Pyridoxal, Pyridoxamine and their phosphorylated derivatives such as Pyridoxine phosphate, Pyridoxal phosphate and Pyridoxamine derivatives respectively. Vitamin B6 is essential for the metabolism of amino acid, glycogen and fatty acids, for nerve functions, for the formation of red blood cells and also helps the skin healthy. Vitamin B6 is also used for the synthesis of nucleic acid, Haemoglobin, Sphingomyelin, other Sphingolipids, Serotonin, Dopamine, Noradrenaline and GABA.Pharmacokinets of Vit B6Absorption: Vitamin B6 is readily absorbed after oral administration.
Distribution: It is mainly distributed in the body in protein bound form. It is stored primarily in the liver and to a lesser extent muscle and brain.
Metabolism: It is metabolised in the liver
Onset of Action for Vit B6N/ADuration of Action for Vit B6N/AHalf Life of Vit B615-20 daysSide Effects of Vit B61. Neuropathy
2. Unstable gait
3. Drowsiness
4. Perioral numbness
5. Paresthesia
6. Numbness of feet
7. Somnolence
8. Sensory neuropathy
9. Ataxia
Contra-indications of Vit B61. Hypersensitivity to Vitamin B6Special Precautions while taking Vit B6N/APregnancy Related InformationMay be usedOld Age Related InformationMay be usedBreast Feeding Related InformationUse with cautionChildren Related InformationUse with caution
NEONATES: Contraindicated
Indications for Vit B61. Vitamin B6 deficiency including inadequate diet and drug induced causes
2. Neuropathy
3. Premenstrual syndrome
4. Hyperoxaluria type 1
5. Metabolic disorder
6. Isoniazid poisoning
Interactions for Vit B6Cycloserine, Hydralazine, Isoniazide, Oral contraceptive, Penicillamine: Increase Pyridoxine requirement.
Levodopa: Pyridoxine reverses the therapeutic effect of Levodopa.
Phenobarbital, Phenytoin: Pyridoxine decreases serum level of these anticonvulsants.
Typical Dosage for Vit B6Adult: 10 - 20 mg / day
Dietary deficiency: 2.5 -10 mg / day for effective therapeutic response is obtained.
Maintenance dose: 2 - 5 mg / day for several weeks.
Drug induced deficiency: 100 - 200 mg / day for 3 weeks.
Maintenance dose: 25 - 100 mg / day
Neuropathy: 50 - 200 mg /day
Premenstrual syndrome: 40 - 500 mg / day
Hyperoxaluria type 1: 25 - 300 mg / day
Metabolic disorder: 100-500 mg /day.
Isoniazid poisoning: Initial dose: 1 - 4 g as IV administration, then 1 g IM every 30 minute until Pyridoxine dose is equal to the Isoniazid dose has been given.
Schedule of Vit B6N/AStorage Requirements for Vit B6Store it at 15 - 30 degree C. Protect from moisture and heat.Effects of Missed Dosage of Vit B6Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Vit B6Give supportive measures and symptomatic treatment. The signs of Pyridoxine overdose can be resolved by discontinuation (withdrawal) of Pyridoxine.Vit B3
About Vit B3N/AMechanism of Action of Vit B3Niacin refers to Nicotinic acid as well as Nicotinamide which exerts it`s action by influencing metabolic reactions. It is converted in to coenzymes Ncotinamide adenine dinucleotide (NAD) and it`s phosphate Ncotinamide adenine dinucleotide phosphate (NADP) involved in oxidation reduction reactions. These pyridine nucleotides act as hydrogen acceptors in the electron transport chain in tissue respiration, glycolysis, and fat synthesis. Nicotinic acid in high doses has vasodilator effects and also improves lipid profile; reduces serum cholesterol, raises HDL level, lowers VLDL, and LDL levels.Pharmacokinets of Vit B3Absorption: Well absorbed orally, Distribution: Widely distributed in the body, and also secreted in to breast milk, Modest amounts are stored in liver, Metabolism: Metabolized in to active metabolites in liver, Excretion: Extra drug is excreted through urine.Onset of Action for Vit B3N/ADuration of Action for Vit B3N/AHalf Life of Vit B3N/ASide Effects of Vit B31. Flushing
2. Activation of peptic ulcer
3. Nausea
4. Vomiting
5. Diarrhoea
6. Headache
7. Rashes
8. Pruritus
9. Hypotension
10. Arrhythmias
11. Hepatic impairment
Contra-indications of Vit B31. Hypersensitivity to the drug
2. Hepatic impairment
3. Peptic ulcer
4. Severe hypotension
5. Arterial haemorrhage
Special Precautions while taking Vit B31.History of liver disease
2.Gall bladder diseases
3.Gout
4.Coronary artery diseases
5.Diabetes mellitus
6.When use along with Statins reduces the dosage of StatinsPregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with cautionIndications for Vit B31. Pellagra
2. Niacin deficiency
3. Hartnup disease
4. Hyperlipidaemia (only nicotinic acid
5. Peripheral vascular diseases (only nicotinic acid)Interactions for Vit B3Aspirin: May decrease the metabolic clearance of nicotinic acid
Sympathetic blocking agent: May cause added vasodilation and hypotension
Isoniazid: may deplete levels of niacin and cause deficiency.
Typical Dosage for Vit B3Oral:
Pellagra: 200 to 500mg daily in divided doses
Prophylactically: 20 to 50mg daily.
Dietary supplement: 10 to 20mg daily
Peripheral vascular diseases (only nicotinic acid): 100 to 150mg three to five times daily. Alternatively 1000 to 2000g once daily at bed time.
Hyperlipidaemia (only nicotinic acid): 1.5 to 6g daily in two to four divided doses with or after meals.
Hartnup disease: 50 to 200mg daily in divided doses.
Schedule of Vit B3C1Storage Requirements for Vit B3Store at controlled room temperature at a range of 15 to 30 degree CEffects of Missed Dosage of Vit B3Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Vit B3Provide supportive measures and symptomatic treatmentZinc
About ZincTrance metal, Dietary mineral, Nutritional supplement,Treatment of zinc deficiency,in wound healing.Mechanism of Action of ZincZinc acts as a cofactor for more than 70 different enzymes. Zinc dependent enzymes are involved in the metabolism of carbohydrates, lipids, and proteins. Zinc facilitates wound healing, normal growth rates, normal skin hydration and maintains senses of taste and smell. It provides normal growth and tissue repair. It also helps in development of cell mediated immunity.Pharmacokinets of ZincAbsorption: Poorly absorbed orally, Distribution: Zinc is distributed mainly in to skeletal muscle, skin, bone, pancreas, kidney, liver, retina, prostate, RBC, and WBC. Excretion: Excreted mainly through intestine; only 2% loss in the urine.Onset of Action for ZincN/ADuration of Action for ZincN/AHalf Life of ZincN/ASide Effects of Zinc1. Nausea
2. Vomiting
3. Abdominal distress
4. Gastric ulceration
5. Rashes
Contra-indications of ZincN/ASpecial Precautions while taking Zinc1.Don`t exceed prescribed dose
2.Renal failure
3.Biliary obstruction
Pregnancy Related InformationUse with cautionOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Zinc1. Zinc deficiency
2. Acne vulgaris
3. Chronic skin ulcers
4. Adjunct to antimicrobials
5. Delayed wound healing
6. Alopecia
Interactions for ZincFluoroquinolones, Tetracyclines: Decreased GI absorption and serum levels of some fluoroquinolone.
Pencillamine: Reduced absorption of zinc.
Iron: Reduced absorption of iron and vice versa.
Typical Dosage for ZincAdults: 25 to 50mg zinc daily or 1 to 2 tablets daily.
Children: 5mg/kg 1 to 3 times daily.
Schedule of ZincN/AStorage Requirements for ZincStore at a temperature below 30 degree CEffects of Missed Dosage of ZincTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of ZincProvide symptomatic treatment and supportive measuresHome Delivery for Iron (Ferric ammonium citrate) + Vit B12 + Vit B6 + Vit B3 + Zinc in Your City
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