Cyproheptadine Pharmacology

Cyproheptadine

About Cyproheptadine

Piperidine (nonselective) First Generation H1 Antagonist ,anticholinergic and antiserotonergic(5-HT2 receptor antagonist), antihistaminic,appetite stimulant.

Mechanism of Action of Cyproheptadine

Cyproheptadine is a sedative antihistamine with serotonin antagonist, and calcium-channel blocking actions. It competes with Histamine for H1 receptors present in the smooth muscle of gastrointestinal tract, bronchi, large blood vessels and uterus. Histamine cannot bind with H1 receptors and cannot produce histamine induced allergic symptoms. Cyproheptadine blocks serotonin receptors preferentially block 5HT2A receptor and are useful in migraine prophylaxis. It has weak anticholinergic activity and possesses mild CNS depressant properties. It also blocks voltage sensitive calcium channel in islet of pancreas and smooth muscle. Cyproheptadine increases appetite and cause weight gain.

Pharmacokinets of Cyproheptadine

Absorption: Cyproheptadine is well absorbed after oral administration. Distribution: It is distributed in the body in highly protein bound form. Metabolism: It is extensively metabolised in the liver. Excretion: Metabolites are excreted primarily in the urine; unchanged drug and small amount of metabolites are excreted through faeces.

Onset of Action for Cyproheptadine

15 - 60 minutes

Duration of Action for Cyproheptadine

N/A

Half Life of Cyproheptadine

1 - 4 hours

Side Effects of Cyproheptadine

1.Dizziness
2.Drowsiness
3.Fatigue
4.Nervousness
5.Sleepiness
6.Epigastric distress
7.Dry mouth
8.Nausea
9.Vomiting
10.Rash
11.Urine retention
12.Weight gain

Contra-indications of Cyproheptadine

1.Hypersensitivity to Cyproheptadine and other drugs of similar structure
2.Angle closure glaucoma
3.Acute asthma
4.Peptic ulcer
5.Bladder neck obstruction
6.Prostatic hyperplasia
7.Pyloroduodenal obstruction
8.Debilitated patients
9.Patient on monoamine oxidase inhibitory therapy.

Special Precautions while taking Cyproheptadine

1.Hypertension
2.Hyperthyroidism
3.Increased intraocular pressure
4.Bronchial asthma
5.Patient should be cautioned against activities requiring mental alertness such as driving, operating machine or involving in any hazardous activities 6.Avoid alcohol

Pregnancy Related Information

Use with caution

Old Age Related Information

Contraindicated.

Breast Feeding Related Information

Contraindicated.

Children Related Information

Use with caution
NEONATES: contraindicated

Indications for Cyproheptadine

1.Antiallergic
2.Appetite stimulant
3.Cluster headache

Interactions for Cyproheptadine

Alcohol and other CNS depressants (hypnotics, sedatives, tranquilizers, anti-anxiety drugs, narcotic analgesics): CNS depressant action potentiated.
MAOIs, tricylic antidepressants and atropine: Antimuscarinic action potentiated.
Aminoglycosides: Ototoxicity produced by aminoglycosides masked.

Typical Dosage for Cyproheptadine

Adult: 12 - 16 mg / day in 3 - 4 divided doses.
Maximum dose: 32 mg / day
Migraine prophylaxis and vascular headaches: Initial dose: 4 mg and may be repeated after 30 minutes; A maintenance dose of 4 mg may be given every 4 to 6 hours.

Children above 6 years: 8 - 12 mg / day in 2 - 3 divided doses
Maximum dose: 16 mg / day
Children 2 - 6: 4 - 6 mg / day in 2 - 3 divided doses
Maximum dose: 12 mg / day

Schedule of Cyproheptadine

Storage Requirements for Cyproheptadine

Store at room temperature in a tightly closed container.

Effects of Missed Dosage of Cyproheptadine

Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.

Effects of Overdose of Cyproheptadine

Give supportive measures and symptomatic treatment. Drug can be removed from the body by gastric lavage or by inducing vomiting. Absorption of the drug can be reduced by administration of activated charcoal. Hypotension can be treated by vasopressors and seizure with Diazepam or Phenytoin.

Home Delivery for Cyproheptadine in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including cyproheptadine.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for cyproheptadine and other medicines and health products. Home delivery services for cyproheptadine may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take cyproheptadine only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for cyproheptadine before they complete the sale. You can get this information while placing the order for cyproheptadine with the pharmacy.

Cyproheptadine is a generic medicine name and there are several brands available for it. Some of the brands for cyproheptadine might be better known than cyproheptadine itself. If the pharmacy that's willing to deliver medicines to your home doesn't have cyproheptadine in stock, you can ask for one of the branded alternatives for cyproheptadine.