Vit B12 + Vit B1 + Vit B3 + Vit B5 + Vit B6 + Magnesium + Glutamic Acid Pharmacology

Vit B12 + Vit B1 + Vit B3 + Vit B5 + Vit B6 + Magnesium + Glutamic Acid

About Vit B12 + Vit B1 + Vit B3 + Vit B5 + Vit B6 + Magnesium + Glutamic Acid
N/A
Mechanism of Action of Vit B12 + Vit B1 + Vit B3 + Vit B5 + Vit B6 + Magnesium + Glutamic Acid
N/A
Pharmacokinets of Vit B12 + Vit B1 + Vit B3 + Vit B5 + Vit B6 + Magnesium + Glutamic Acid
N/A
Onset of Action for Vit B12 + Vit B1 + Vit B3 + Vit B5 + Vit B6 + Magnesium + Glutamic Acid
N/A
Duration of Action for Vit B12 + Vit B1 + Vit B3 + Vit B5 + Vit B6 + Magnesium + Glutamic Acid
N/A
Half Life of Vit B12 + Vit B1 + Vit B3 + Vit B5 + Vit B6 + Magnesium + Glutamic Acid
N/A
Side Effects of Vit B12 + Vit B1 + Vit B3 + Vit B5 + Vit B6 + Magnesium + Glutamic Acid
N/A
Contra-indications of Vit B12 + Vit B1 + Vit B3 + Vit B5 + Vit B6 + Magnesium + Glutamic Acid
N/A
Special Precautions while taking Vit B12 + Vit B1 + Vit B3 + Vit B5 + Vit B6 + Magnesium + Glutamic Acid
N/A
Pregnancy Related Information
N/A
Old Age Related Information
N/A
Breast Feeding Related Information
N/A
Children Related Information
N/A
Indications for Vit B12 + Vit B1 + Vit B3 + Vit B5 + Vit B6 + Magnesium + Glutamic Acid
N/A
Interactions for Vit B12 + Vit B1 + Vit B3 + Vit B5 + Vit B6 + Magnesium + Glutamic Acid
N/A
Typical Dosage for Vit B12 + Vit B1 + Vit B3 + Vit B5 + Vit B6 + Magnesium + Glutamic Acid
N/A
Schedule of Vit B12 + Vit B1 + Vit B3 + Vit B5 + Vit B6 + Magnesium + Glutamic Acid
N/A
Storage Requirements for Vit B12 + Vit B1 + Vit B3 + Vit B5 + Vit B6 + Magnesium + Glutamic Acid
N/A
Effects of Missed Dosage of Vit B12 + Vit B1 + Vit B3 + Vit B5 + Vit B6 + Magnesium + Glutamic Acid
N/A
Effects of Overdose of Vit B12 + Vit B1 + Vit B3 + Vit B5 + Vit B6 + Magnesium + Glutamic Acid
N/A

Vit B12

About Vit B12
N/A
Mechanism of Action of Vit B12
Vitamin B12 is an essential constituent for growth, cell reproduction, hematopoiesis, and nucleoprotein and myelin synthesis. Vitamin B12 is converted in to coenzyme B12 in the tissues which is essential for conversion of methyl-malonate to succinate and synthesis of methionine from homocystine. It is also associated with fat and carbohydrate metabolism and protein synthesis. Cells characterized by rapid division such as epithelial cells, bone marrow, and myeloid cells appear to have greatest requirement of Cyanocobalamin.
Pharmacokinets of Vit B12
Absorption: Absorbed irregularly after oral administration and absorption depends on Ca and intrinsic factor. It is also administered subcutaneously and intramuscularly.
Distribution: Distributed in to liver, bone marrow, and other tissues. It crosses the placenta and appears in breast milk.
Metabolism: It is metabolized in liver.
Excretion: In normal dosage it is reabsorbed from bile and a minute portion is excreted through urine but the extra drug is excreted through urine.
Onset of Action for Vit B12
N/A
Duration of Action for Vit B12
N/A
Half Life of Vit B12
N/A
Side Effects of Vit B12
1. Anaphylaxis
2. Anaphylactoid reactions
3. Pain and burning sensation at injection site
4. Itching
5. Urticaria
6. Transient diarrhea
7. Peripheral vascular thrombosis
8. Pulmonary oedema
Contra-indications of Vit B12
1. Hypersensitivity to the drug
2. Leber`s disease
Special Precautions while taking Vit B12
1. Anemic patients with coexisting cardiac, pulmonary and hypertensive diseases.
Pregnancy Related Information
May be used
Old Age Related Information
May be used
Breast Feeding Related Information
May be used
Children Related Information
Use with caution
NEONATES : Use with caution
Indications for Vit B12
1. Vitamin B12 deficiency
2. Pernicious Anaemia
3. Peripheral neuropathy (diabetic, alcoholic, and drug induced)
Interactions for Vit B12
N/A
Typical Dosage for Vit B12
I.M., S.C.:
Pernicious Anaemia: 100mcg daily for 1 week followed by the same dose given on alternate days for 7 doses and then every 3 to 4days for another 3 weeks. This regimen should be followed by 100mcg monthly for life. Concurrently administer folic acid if required.
Vitamin B12 deficiency other than pernicious Anaemia: 30mcg daily for 5 to 10days depending up on the severity of the condition.
Maintenance dosage: 100 to 200mcg once monthly.
Children: 100mcg I.M. or S.C. over the course of 2 or more weeks.
Maintenance dosage: 60mcg monthly I.M. or S.C.
Schilling test flushing dose:
Adults and Children: 1000mcg I.M. in single dose
Recommended RDA (recommended dietary allowance) for Vitamin B12:
Infants up to 6months of age: 0.3mcg.
Children age 6 months to 1 year: 0.5mcg.
Children age 1 to 3: 0.7mcg.
Children age 4 to 6: 1mcg.
Children age 7 to 10: 1.4mcg.
Children age 11 to adult: 2mcg..
Pregnant women: 2.2mcg.
Breast feeding women: 2.6mcg.
Schedule of Vit B12
C
Storage Requirements for Vit B12
Store at room temperature range of 15 to 30 degree C.in a light resistant well closed container in a dry place.
Effects of Missed Dosage of Vit B12
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Vit B12
Not applicable. Even in large doses Vitamin B12 isn`t usually toxic.

Vit B1

About Vit B1

Physiological functions: Thiamine pyrophosphate is a coenzyme and the active form of vitamin B. It functions as coenzyme in decarboxylation of a-keto acid and in Hexose Monophosphate shunt.
Deficiency symptoms: In severe vitamin B1 deficiency beriberi develops. It is of two types:
a) Wet beriberi
b) Dry beriberi
Wet beriberi: In this the symptoms are related to the cardiovascular system and they are palpitations, tachycardia, dyspnoea, ECG changes, oedema, and high output cardiac failure.
Dry beriberi: The symptoms and signs are related to the Nervous system. The main features are peripheral neuritis, hyperaesthesia (localized areas) or anaesthesia, there is gradual loss in muscle strength, wrist drop, poor memory, depression, lack of initiative and anorexia.
Mechanism of Action of Vit B1
Thiamine exerts it`s action by influencing carbohydrate metabolism. It combines with ATP to form thiamine pyrophosphate in the body. Thiamine pyrophosphate acts as a coenzyme for carbohydrate metabolism, decarboxylation of ketoacids, and hexose monophosphate shunt. It also have plays some role in neuromuscular transmission.
Pharmacokinets of Vit B1
Absorption: Well absorbed orally.
Distribution: Widely distributed in the body. It is also distributed in to breast milk.
Metabolism: Metabolized in the liver.
Excretion: Excess thiamine is excreted through urine.
Onset of Action for Vit B1
N/A
Duration of Action for Vit B1
N/A
Half Life of Vit B1
N/A
Side Effects of Vit B1
1. Angioedema
2. Cardiovascular collapse
3. Cyanosis
4. Restleessness
5. Nausea
6. Haemorrhage
7. Weakness
8. Allergic reactions
9. Tightness of throat
10. Feeling of warmth
11. Urticaria
12. Pruritus
13. Tenderness and induration following I. M. administration
Contra-indications of Vit B1
1. Hypersensitivity to the drug
Special Precautions while taking Vit B1
N/A
Pregnancy Related Information
Use with caution
Old Age Related Information
May be used
Breast Feeding Related Information
Use with caution
Children Related Information
May be used
Indications for Vit B1
1. Thiamine deficiency
2. Dry beriberi
3. Wet beriberi
4. Wernicke`s encephalopathy
5. Hyperemesis gravidarum
6. Korsakoffs syndrome
7. Polyneuritis secondary to alcoholism
8. Multiple neurosis
9. Toxic and confusional states
10. Anorexia nervosa
11. Delirium
Interactions for Vit B1
N/A
Typical Dosage for Vit B1
Oral :
In mild deficiency: 10 to 25mg/day.
In severe deficiency: 200 to 300mg/day.
I.M, I.V.:
Beriberi:
Adults: 10 to 20mg I.M. depending up on the severity of the condition (Up to 100mg I.M. or I.V. for severe cases); thrice daily for two weeks followed by dietary correction and multivitamin supplement containing 5 to 30mg Thiamine/day in single or divided doses for 1 month.
Wernicke`s encephalopathy: 100mg I.V. followed by 50 to 100mg IM. or I.V./day.
"Wet beriberi with heart failure": 10 to 30mg I.V. for emergency treatment.

Schedule of Vit B1
C1 (Oral)
Storage Requirements for Vit B1
Store in a well closed container; in a cool place and protect from light.
Effects of Missed Dosage of Vit B1
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Vit B1
Provide symptomatic treatment and supportive measures.

Vit B3

About Vit B3
N/A
Mechanism of Action of Vit B3
Niacin refers to Nicotinic acid as well as Nicotinamide which exerts it`s action by influencing metabolic reactions. It is converted in to coenzymes Ncotinamide adenine dinucleotide (NAD) and it`s phosphate Ncotinamide adenine dinucleotide phosphate (NADP) involved in oxidation reduction reactions. These pyridine nucleotides act as hydrogen acceptors in the electron transport chain in tissue respiration, glycolysis, and fat synthesis. Nicotinic acid in high doses has vasodilator effects and also improves lipid profile; reduces serum cholesterol, raises HDL level, lowers VLDL, and LDL levels.
Pharmacokinets of Vit B3
Absorption: Well absorbed orally, Distribution: Widely distributed in the body, and also secreted in to breast milk, Modest amounts are stored in liver, Metabolism: Metabolized in to active metabolites in liver, Excretion: Extra drug is excreted through urine.
Onset of Action for Vit B3
N/A
Duration of Action for Vit B3
N/A
Half Life of Vit B3
N/A
Side Effects of Vit B3
1. Flushing
2. Activation of peptic ulcer
3. Nausea
4. Vomiting
5. Diarrhoea
6. Headache
7. Rashes
8. Pruritus
9. Hypotension
10. Arrhythmias
11. Hepatic impairment
Contra-indications of Vit B3
1. Hypersensitivity to the drug
2. Hepatic impairment
3. Peptic ulcer
4. Severe hypotension
5. Arterial haemorrhage
Special Precautions while taking Vit B3
1.History of liver disease
2.Gall bladder diseases
3.Gout
4.Coronary artery diseases
5.Diabetes mellitus
6.When use along with Statins reduces the dosage of Statins
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution
Indications for Vit B3
1. Pellagra
2. Niacin deficiency
3. Hartnup disease
4. Hyperlipidaemia (only nicotinic acid
5. Peripheral vascular diseases (only nicotinic acid)
Interactions for Vit B3
Aspirin: May decrease the metabolic clearance of nicotinic acid
Sympathetic blocking agent: May cause added vasodilation and hypotension
Isoniazid: may deplete levels of niacin and cause deficiency.
Typical Dosage for Vit B3
Oral:
Pellagra: 200 to 500mg daily in divided doses
Prophylactically: 20 to 50mg daily.
Dietary supplement: 10 to 20mg daily
Peripheral vascular diseases (only nicotinic acid): 100 to 150mg three to five times daily. Alternatively 1000 to 2000g once daily at bed time.
Hyperlipidaemia (only nicotinic acid): 1.5 to 6g daily in two to four divided doses with or after meals.
Hartnup disease: 50 to 200mg daily in divided doses.
Schedule of Vit B3
C1
Storage Requirements for Vit B3
Store at controlled room temperature at a range of 15 to 30 degree C
Effects of Missed Dosage of Vit B3
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Vit B3
Provide supportive measures and symptomatic treatment

Vit B5

About Vit B5
Vitamin , A water-soluble B complex vitamin.
Mechanism of Action of Vit B5
Pantothenic acid exerts it`s actions by influencing metabolic reactions. It is a component of coenzyme-A which functions in carbohydrate, fat, steroid and porphyrin metabolism by catalyzing acetate transfer reactions.
Pharmacokinets of Vit B5
Absorption: Well absorbed orally.
Distribution: Widely distributed in the body tissues, and appears in the breast milk.
Excretion: 70% excreted unchanged in urine and 30% in faeces.
Onset of Action for Vit B5
N/A
Duration of Action for Vit B5
N/A
Half Life of Vit B5
N/A
Side Effects of Vit B5
N/A
Contra-indications of Vit B5
N/A
Special Precautions while taking Vit B5
N/A
Pregnancy Related Information
May be used
Old Age Related Information
May be used
Breast Feeding Related Information
May be used
Children Related Information
May be used
Indications for Vit B5
1. Nutritional supplement in conjunction with other B vitamins
2. Post operative paralytic ileus.
Interactions for Vit B5
Tetracycline: Vitamin B5 should not be taken at the same time as the Tetracycline because it interferes with the absorption and effectiveness of this medication.
B vitamins should be taken at different times from tetracycline.
Typical Dosage for Vit B5
Oral: 50 to 100mg daily.
Schedule of Vit B5
C1
Storage Requirements for Vit B5
Store in a well closed container; in a cool place and protect from light.
Effects of Missed Dosage of Vit B5
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Vit B5
Provide symptomatic treatment and supportive measures.

Vit B6

About Vit B6
Physiological functions: It is involved as a coenzyme (Pyridoxal phosphate) in metabolism of tryptophan, in several metabolic transformations of amino acids including transamination, decarboxylation & racemization.
Deficiency symptoms: Peripheral neuritis, seizures, stomatitis, glossitis, anaemia, seborrhea like lesions.
Mechanism of Action of Vit B6
Vitamin B6 is a collective term for Pyridoxine, Pyridoxal, Pyridoxamine and their phosphorylated derivatives such as Pyridoxine phosphate, Pyridoxal phosphate and Pyridoxamine derivatives respectively. Vitamin B6 is essential for the metabolism of amino acid, glycogen and fatty acids, for nerve functions, for the formation of red blood cells and also helps the skin healthy. Vitamin B6 is also used for the synthesis of nucleic acid, Haemoglobin, Sphingomyelin, other Sphingolipids, Serotonin, Dopamine, Noradrenaline and GABA.
Pharmacokinets of Vit B6
Absorption: Vitamin B6 is readily absorbed after oral administration.
Distribution: It is mainly distributed in the body in protein bound form. It is stored primarily in the liver and to a lesser extent muscle and brain.
Metabolism: It is metabolised in the liver
Onset of Action for Vit B6
N/A
Duration of Action for Vit B6
N/A
Half Life of Vit B6
15-20 days
Side Effects of Vit B6
1. Neuropathy
2. Unstable gait
3. Drowsiness
4. Perioral numbness
5. Paresthesia
6. Numbness of feet
7. Somnolence
8. Sensory neuropathy
9. Ataxia
Contra-indications of Vit B6
1. Hypersensitivity to Vitamin B6
Special Precautions while taking Vit B6
N/A
Pregnancy Related Information
May be used
Old Age Related Information
May be used
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution
NEONATES: Contraindicated
Indications for Vit B6
1. Vitamin B6 deficiency including inadequate diet and drug induced causes
2. Neuropathy
3. Premenstrual syndrome
4. Hyperoxaluria type 1
5. Metabolic disorder
6. Isoniazid poisoning
Interactions for Vit B6
Cycloserine, Hydralazine, Isoniazide, Oral contraceptive, Penicillamine: Increase Pyridoxine requirement.
Levodopa: Pyridoxine reverses the therapeutic effect of Levodopa.
Phenobarbital, Phenytoin: Pyridoxine decreases serum level of these anticonvulsants.
Typical Dosage for Vit B6
Adult: 10 - 20 mg / day
Dietary deficiency: 2.5 -10 mg / day for effective therapeutic response is obtained.
Maintenance dose: 2 - 5 mg / day for several weeks.
Drug induced deficiency: 100 - 200 mg / day for 3 weeks.
Maintenance dose: 25 - 100 mg / day
Neuropathy: 50 - 200 mg /day
Premenstrual syndrome: 40 - 500 mg / day
Hyperoxaluria type 1: 25 - 300 mg / day
Metabolic disorder: 100-500 mg /day.
Isoniazid poisoning: Initial dose: 1 - 4 g as IV administration, then 1 g IM every 30 minute until Pyridoxine dose is equal to the Isoniazid dose has been given.
Schedule of Vit B6
N/A
Storage Requirements for Vit B6
Store it at 15 - 30 degree C. Protect from moisture and heat.
Effects of Missed Dosage of Vit B6
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Vit B6
Give supportive measures and symptomatic treatment. The signs of Pyridoxine overdose can be resolved by discontinuation (withdrawal) of Pyridoxine.

Magnesium

About Magnesium
Magnesium is essential for enzyme activity, calcium and potassium uptake, nerve transmission, bone formation and metabolism of carbohydrates and minerals. It is magnesium, not calcium, which helps form hard tooth enamel, resistant to decay. Like calcium and chloride, magnesium also plays a role in regulating the acid-alkaline balance in the body. High magnesium levels in drinking water have been linked to resistance to heart disease. Although it is found in many foods, including dairy products, nuts, vegetables, fish, meat and seafood, deficiencies are common in America due to soil depletion, poor absorption and lack of minerals in drinking water. A diet high in carbohydrates, oxalic acid in foods like raw spinach and phytic acid found in whole grains can cause deficiencies. An excellent source of usable magnesium is beef, chicken or fish broth. High amounts of zinc and vitamin D increase magnesium requirements. Magnesium deficiency can result in coronary heart disease, chronic weight loss, obesity, fatigue, epilepsy and impaired brain function. Chocolate cravings are a sign of magnesium deficiency.
Mechanism of Action of Magnesium
N/A
Pharmacokinets of Magnesium
N/A
Onset of Action for Magnesium
N/A
Duration of Action for Magnesium
N/A
Half Life of Magnesium
N/A
Side Effects of Magnesium
N/A
Contra-indications of Magnesium
N/A
Special Precautions while taking Magnesium
N/A
Pregnancy Related Information
N/A
Old Age Related Information
N/A
Breast Feeding Related Information
N/A
Children Related Information
N/A
Indications for Magnesium
N/A
Interactions for Magnesium
N/A
Typical Dosage for Magnesium
N/A
Schedule of Magnesium
N/A
Storage Requirements for Magnesium
N/A
Effects of Missed Dosage of Magnesium
N/A
Effects of Overdose of Magnesium
N/A

Glutamic Acid

About Glutamic Acid
Miscellaneous Gastrointestinal Agent, ,non-essential amino acid, Treatment of hypochlorhydria and achlorhydria.
Mechanism of Action of Glutamic Acid
N/A
Pharmacokinets of Glutamic Acid
N/A
Onset of Action for Glutamic Acid
N/A
Duration of Action for Glutamic Acid
N/A
Half Life of Glutamic Acid
N/A
Side Effects of Glutamic Acid
N/A
Contra-indications of Glutamic Acid
N/A
Special Precautions while taking Glutamic Acid
N/A
Pregnancy Related Information
N/A
Old Age Related Information
N/A
Breast Feeding Related Information
N/A
Children Related Information
N/A
Indications for Glutamic Acid
N/A
Interactions for Glutamic Acid
N/A
Typical Dosage for Glutamic Acid
N/A
Schedule of Glutamic Acid
N/A
Storage Requirements for Glutamic Acid
N/A
Effects of Missed Dosage of Glutamic Acid
N/A
Effects of Overdose of Glutamic Acid
N/A

Home Delivery for Vit B12 + Vit B1 + Vit B3 + Vit B5 + Vit B6 + Magnesium + Glutamic Acid in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including vit b12 + vit b1 + vit b3 + vit b5 + vit b6 + magnesium + glutamic acid.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for vit b12 + vit b1 + vit b3 + vit b5 + vit b6 + magnesium + glutamic acid and other medicines and health products. Home delivery services for vit b12 + vit b1 + vit b3 + vit b5 + vit b6 + magnesium + glutamic acid may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take vit b12 + vit b1 + vit b3 + vit b5 + vit b6 + magnesium + glutamic acid only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for vit b12 + vit b1 + vit b3 + vit b5 + vit b6 + magnesium + glutamic acid before they complete the sale. You can get this information while placing the order for vit b12 + vit b1 + vit b3 + vit b5 + vit b6 + magnesium + glutamic acid with the pharmacy.

Vit B12 + Vit B1 + Vit B3 + Vit B5 + Vit B6 + Magnesium + Glutamic Acid is a generic medicine name and there are several brands available for it. Some of the brands for vit b12 + vit b1 + vit b3 + vit b5 + vit b6 + magnesium + glutamic acid might be better known than vit b12 + vit b1 + vit b3 + vit b5 + vit b6 + magnesium + glutamic acid itself. If the pharmacy that's willing to deliver medicines to your home doesn't have vit b12 + vit b1 + vit b3 + vit b5 + vit b6 + magnesium + glutamic acid in stock, you can ask for one of the branded alternatives for vit b12 + vit b1 + vit b3 + vit b5 + vit b6 + magnesium + glutamic acid.