Halothane Pharmacology

Halothane

About Halothane
Haloalkane derivative, Inhalation General Anesthetic.
Mechanism of Action of Halothane
Halothane will alter presynaptic activity and the release of neurotransmitters due to alterations in intracellular signaling. Halothane similarly inhibit non-NMDA and NMDA receptor-mediated excitatory postsynaptic currents in both cell types at low concentrations but preferentially blocked responses to exogenously applied AMPA at higher concentrations. Synaptically but not directly evoked action potentials in interneurons were inhibited by halothane.
Pharmacokinets of Halothane
Absorption - It is relatively insoluble in blood; alveolar concentration therefore reaches inspired concentration very rapidly, resulting in a rapid induction of anaesthesia. Distribution- It is distributed initially to areas of high blood flow (brain, heart, liver and kidney). Then distributed into less well-perfused organs.
Metabolism- Metabolized in the liver (oxidation/dehalogenation to yield trifluoroacetic acid, trifluoroacetylethanolamide, chlorobromidifluorethylene, and chloride and bromide radicals
Excretion- 60-80% is exhaled unchanged; the metabolites are excreted in the urine
Onset of Action for Halothane
N/A
Duration of Action for Halothane
N/A
Half Life of Halothane
N/A
Side Effects of Halothane
1. Hepatitis
2. Hepatic necrosis.
3. Shivering during recovery
Contra-indications of Halothane
Contraindicated in patients with hypersensitivity to the drug
Special Precautions while taking Halothane
1.Use with caution in patients with adrenalin treatment
2.Induction of anaesthesia may be delayed. It sensitizes the heart to the action of catecholamines
Pregnancy Related Information
N/A
Old Age Related Information
N/A
Breast Feeding Related Information
N/A
Children Related Information
N/A
Indications for Halothane
1. Inhalational anaesthesia
2. Operations where blood-less field is required
Interactions for Halothane
N/A
Typical Dosage for Halothane
Inhalation-
Adults-
Induction: up to 5% in air oxygen or oxygen/nitrous oxide.
Maintenance dose: 0.5-1.5%.
Children-
Initially give higher % 2.3% then maintain at 0.5-1%.
Schedule of Halothane
N/A
Storage Requirements for Halothane
It should be stored in a cool, dry, well-ventilated area in tightly sealed containers
Effects of Missed Dosage of Halothane
N/A
Effects of Overdose of Halothane
Give symptomatic and supportive treatment

Home Delivery for Halothane in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including halothane.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for halothane and other medicines and health products. Home delivery services for halothane may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take halothane only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for halothane before they complete the sale. You can get this information while placing the order for halothane with the pharmacy.

Halothane is a generic medicine name and there are several brands available for it. Some of the brands for halothane might be better known than halothane itself. If the pharmacy that's willing to deliver medicines to your home doesn't have halothane in stock, you can ask for one of the branded alternatives for halothane.