Megesterol Acetate Pharmacology

Megesterol Acetate

About Megesterol Acetate
A synthetic progesterone derivative, Antineoplastic.
Mechanism of Action of Megesterol Acetate
Drug shows its action by various mechanisms.1.It bind to the receptors (These receptors are very sensitive to the sex hormones which stimulate cell division and its growth) of estrogen present on the cancer cells. Thus it prevents the cell division and cell death. 2. It fools the signal pathway between brain and ovaries by increasing the blood level of another hormone produced in the ovaries. So brain thinks that ovaries are producing too many hormones including estrogen. Then the body switches off signals from brain itself. This results the reduction of estrogen level in blood and prevents the cancer growth associated with it.3. It stimulate the appetite by interfering with the production of mediators such as cachetin.
Pharmacokinets of Megesterol Acetate
Absorption- Rapidly and completely absorbed after oral administration.
Distribution- Widely distributed to the fatty tissues.
Metabolism- It is metabolized in the liver to its metabolites by glucoronide conjugation.
Excretion- Excreted through urine (66.4%) and feces (19.8%).
Onset of Action for Megesterol Acetate
N/A
Duration of Action for Megesterol Acetate
N/A
Half Life of Megesterol Acetate
N/A
Side Effects of Megesterol Acetate
1. Worsening of diabetic symptoms
2. Pain in the chest or abdomen
3. Infection
4. Sarcoma
5. Carpal tunnel syndrome
6. Heartbeat
7. Fluid retention
8. Vaginal bleeding
9. Blood clots in legs or lungs
10. Nausea
11. Constipation
12. Dry mouth
13. Increased salivation
14. Abnormal white blood cell count
15. Confusion
16. Emotional and psychological changes
17. Rash
18. Abnormal sweating
19. Skin disorders
20. Cough
21. Sore throat
22. Lung disorders
23. Hair loss
24. Uncontrolled urination
25. Urinary tract infection
26. Male impotence
27. Hot flashes
28. Sweating
29. Mood changes
30. Pain in hand
31. Trouble sleeping
32. Acne
33. Fluid retention
34. GI disturbances
35. Weight gain
36. Jaundice
37. Premenstrual syndromes
Contra-indications of Megesterol Acetate
1. Hyper sensitivity to the drug
2. Vaginal bleeding
3. Liver disease
Special Precautions while taking Megesterol Acetate
1. Diabetes
2. Hypertension
3. Cardiac disease
4. Renal disease
5. History of depression
Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
N/A
Indications for Megesterol Acetate
1. Breast cancer (advanced)
2. Endometriosis
3. Endometrial hyperplasia
4. Endometrial cancer
5. Cachexia in AIDS
Interactions for Megesterol Acetate
N/A
Typical Dosage for Megesterol Acetate
Oral-
Adult-
Breast cancer:160mg/day in single dose or divided dose
Endometrial carcinoma:40-320mg in divided doses
Cachexia:100-600mg/day
Schedule of Megesterol Acetate
H
Storage Requirements for Megesterol Acetate
Stored at room temperature. Protect from light and excessive moist. Keep out of reach of children.
Effects of Missed Dosage of Megesterol Acetate
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Megesterol Acetate
Give symptomatic and supportive treatment.

Home Delivery for Megesterol Acetate in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including megesterol acetate.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for megesterol acetate and other medicines and health products. Home delivery services for megesterol acetate may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take megesterol acetate only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for megesterol acetate before they complete the sale. You can get this information while placing the order for megesterol acetate with the pharmacy.

Megesterol Acetate is a generic medicine name and there are several brands available for it. Some of the brands for megesterol acetate might be better known than megesterol acetate itself. If the pharmacy that's willing to deliver medicines to your home doesn't have megesterol acetate in stock, you can ask for one of the branded alternatives for megesterol acetate.