Docetaxel Pharmacology

Docetaxel

About Docetaxel
Antimicrotubular, Natural Source (Plant) Derivative, Taxane Derivative, Antineoplastic.
Mechanism of Action of Docetaxel
This paclitaxel congener binds to beta tubuline and enhances the polymerization of tubuline to stable microtubules. It also interacts directly with microtubules and stabilizing them against depolymerization, inhibits normal recognition of the microtubule network necessary for mitosis. This act at G2/M phase of the cell cycle.
Pharmacokinets of Docetaxel
Absorption- Rapidly absorbed after intravenous administration
Distribution- Widely distributed in the body. 94% bound to the plasma proteins
Metabolism- Metabolized in the liver to its metabolites by oxidation
Excretion - Excreted through feces and urine (small amount)
Onset of Action for Docetaxel
N/A
Duration of Action for Docetaxel
N/A
Half Life of Docetaxel
Its plasma half life is 86 hrs
Side Effects of Docetaxel
1. Nausea
2. Vomiting
3. Lowered resistance to infection
4. Bruising or unusual bleeding
5. Anemia
6. Weakness
7. Sore in mouth
8. Taste changes
9. Diarrhea
10. Loss of appetite
11. Visual changes
12. Black, tarry stools
13. Blood in urine or in stool
14. Cough or hoarseness
15. Fever
16. Chills
17. Lower back or side pain
18. Painful or difficult urination
19. Pinpoint red spot on skin
20. Slurred speech
21. Swelling on leg or lower leg
22. Shortness of breath
23. Bloody vomiting
24. Thinned or brittle hair
25. Mouth blistering
26. Thrombocytopenia
27. Leucopenia
28. Erythematosus patches
29. Eruptions
30. Scleroderma
31. Onycholysis
32. Alopecia
33. Asthenia
34. Arthralgia
35. Myalgia
36. Mucositis
37. Tachycardia
38. Atrial flutter
39. Dysrrrythmia
40. Hypertension
41. Heart failure
42. Stomatitis
43. Increase of hepatic transaminase, bilirubin and alkaline phosphatase level
Contra-indications of Docetaxel
1. Hyper sensitivity to the drug or other ingredient of the drug.
2. Severe bone marrow depression
3. Severe liver diseases
Special Precautions while taking Docetaxel
1.Hepatic impairment
2.Monitor blood functions, liver functions and blood counts regularly

Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated
Children Related Information
Use with caution
Indications for Docetaxel
1. Breast cancer (metastatic)
2. Prostate cancer
3. Lung cancer
4. Stomach cancer
5. Liver cancer
6. Renal cancer
7. Melanoma
Interactions for Docetaxel
N/A
Typical Dosage for Docetaxel
Intravenous-
Adult-
Breast cancer: 60 to 100mg/metre square over 1 hr every 3 weeks
Lung cancer: 100mg/metre square over 1 hr every 3 weeks
In combination therapy :75-100mg/metre square over 1 hr every 3 weeks
Schedule of Docetaxel
N/A
Storage Requirements for Docetaxel
Stored at 2 - 8 degree C. Protect from light.
Effects of Missed Dosage of Docetaxel
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Docetaxel
Give symptomatic and supportive treatment. Monitor patient`s vital functions regularly.

Home Delivery for Docetaxel in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including docetaxel.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for docetaxel and other medicines and health products. Home delivery services for docetaxel may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take docetaxel only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for docetaxel before they complete the sale. You can get this information while placing the order for docetaxel with the pharmacy.

Docetaxel is a generic medicine name and there are several brands available for it. Some of the brands for docetaxel might be better known than docetaxel itself. If the pharmacy that's willing to deliver medicines to your home doesn't have docetaxel in stock, you can ask for one of the branded alternatives for docetaxel.