Cladribine Pharmacology

Cladribine

About Cladribine
Antimetabolite (Purine Antagonist), adenosine deaminase inhibitor, Antineoplastic.
Mechanism of Action of Cladribine
Cladribine is a purine nucleoside analogue. It enters the tumor cell and undergoes phosphorylation by deoxycytidine kinase and converted to Cladribine triphosphate. Since it is a purine analog it is incorporated in DNA strands and inhibits DNA synthesis and also the repair of existing DNA. It is cytotoxic to both actively dividing and quiescent cells.
Pharmacokinets of Cladribine
Absorption: It is moderately absorbed after oral administration. It is usually administered intravenously. Distribution: About 20% of the drug is distributed in protein bound form. It crosses the blood brain barrier and reaches cerebrospinal fluid. Excretion: The drug is excreted mainly through kidney.
Onset of Action for Cladribine
N/A
Duration of Action for Cladribine
N/A
Half Life of Cladribine
5.5 hours
Side Effects of Cladribine
1.Headache
2.Fever
3.Malaise
4.Fatigue
5.Nausea
6.Diarrhoea
7.Constipation
8. Rash
9.Myalgia
10.Purpura
11.Pruritus
12.Infection



Contra-indications of Cladribine
Hypersensitivity to the drug
Special Precautions while taking Cladribine
1.Renal impairment
2.Hepatic impairment
Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated
Children Related Information
Contraindicated
Indications for Cladribine
1.Hairy cell leukaemia
2.Cutaneous Lymphocytic leukemia
3.Cutaneous T-cell lymphoma
4.Acute lymphoid leukemia
5.Chronic lymphocytic leukaemia
6.Malignant lymphoma
7.Acute myeloid leukemia
8.Mycosis fungoides
9.Histiocytosis
Interactions for Cladribine
N/A
Typical Dosage for Cladribine
IV INFUSION
Hairy cell leukemia: 0.09 mg / kg / day for continuous IV infusion for 1 week
Other uses: 0.1 mg / kg / day for continuous IV infusion for 1 week

Schedule of Cladribine
N/A
Storage Requirements for Cladribine
Store at 2 - 8 degree C and protect from light.
Effects of Missed Dosage of Cladribine
N/A
Effects of Overdose of Cladribine
Give supportive measures and symptomatic treatment.

Home Delivery for Cladribine in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including cladribine.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for cladribine and other medicines and health products. Home delivery services for cladribine may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take cladribine only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for cladribine before they complete the sale. You can get this information while placing the order for cladribine with the pharmacy.

Cladribine is a generic medicine name and there are several brands available for it. Some of the brands for cladribine might be better known than cladribine itself. If the pharmacy that's willing to deliver medicines to your home doesn't have cladribine in stock, you can ask for one of the branded alternatives for cladribine.