Temozolomide Pharmacology

Temozolomide

About Temozolomide
Oral alkylating agent (Triazene), Antineoplastic.
Mechanism of Action of Temozolomide
Temozolamide is an alkylating agent. This alkylates the O6 and N7 positions of guanine in DNA and results cross linking/abnormal base pairing/scission of DNA strand of cancer cells. Cross linking of nucleic acid with proteins also takes place in cancer cells.
Pharmacokinets of Temozolomide
Absorption: It is rapidly and completely absorbed after oral administration.
Distribution: Only a very small amount is distributed in protein bound form.
Metabolism: It undergoes metabolism and produces active metabolite and other metabolites.Excretion: It is excreted mainly in urine and small amount in faeces.
Onset of Action for Temozolomide
N/A
Duration of Action for Temozolomide
N/A
Half Life of Temozolomide
1.5 - 1.8 hours
Side Effects of Temozolomide
1.Constipation
2.Diarrhea
3.Nausea
4.Stomatitis
5.Vomiting
6.Anorexia
7.Dizziness
8.Fatigue
9.Headache
10.Weakness
11.Confusion
12.Convulsions
13.Memory Impairment
14.Blurred vision
15.Allergic Reaction
16.Abdominal Pain
17.Arthralgia
18.Thrombocytopenia
19.Insomnia
20.Coughing
21.Dyspnoea
22.Alopecia
23.Dry Skin
24.Erythema
25.Pruritus

Contra-indications of Temozolomide
Hypersensitivity to Temozolamide
Special Precautions while taking Temozolomide
1.Hepatic impairment
2.Renal impairment
Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated
Children Related Information
Contraindicated
Indications for Temozolomide
Brain tumors
Interactions for Temozolomide
N/A
Typical Dosage for Temozolomide
Oral:
75mg/metre square for 42 days.
Schedule of Temozolomide
H
Storage Requirements for Temozolomide
Store at room temperature at a range of 15 to 25degree C. Protect from heat, light and moisture. Keep out of the reach of children.
Effects of Missed Dosage of Temozolomide
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.

Effects of Overdose of Temozolomide
Provide supportive measures and symptomatic treatment.

Home Delivery for Temozolomide in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including temozolomide.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for temozolomide and other medicines and health products. Home delivery services for temozolomide may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take temozolomide only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for temozolomide before they complete the sale. You can get this information while placing the order for temozolomide with the pharmacy.

Temozolomide is a generic medicine name and there are several brands available for it. Some of the brands for temozolomide might be better known than temozolomide itself. If the pharmacy that's willing to deliver medicines to your home doesn't have temozolomide in stock, you can ask for one of the branded alternatives for temozolomide.