Thio-TEPA Pharmacology

Thio-TEPA

About Thio-TEPA
Alkylating Agent, Antineoplastic.
Mechanism of Action of Thio-TEPA
Thiotepa is an alkylating drug which produces the death of cancer cells by an alkylation mechanism.It binds with cross linking strands of DNA and RNA and inhibits protein synthesis.
Pharmacokinets of Thio-TEPA
Absorption:It is incompletely absorbed after oral administration.Metabolism:It is extensively metabolized in the liver.Excretion:Drug and its metabolites are excreted in the urine.
Onset of Action for Thio-TEPA
N/A
Duration of Action for Thio-TEPA
N/A
Half Life of Thio-TEPA
2.5hours
Side Effects of Thio-TEPA
1.Headache
2.Dizziness
3.Fatigue
4.Weakness
5.Rash
6.Urticaria
7.Laryngeal edema
8.Asthma
9.Anaphylactic shock
10.Wheezing.
11.Contact dermatitis
12.Pain at the injection site.
13.Nausea
14.Vomiting
15.Abdominal pain
16.Anorexia
17.Dysuria
18.Urinary retention
19.Blurred vision.
20.Dermatitis
21.Alopecia.
22.Conjunctivitis.
23.Amenorrhea
Contra-indications of Thio-TEPA
Hypersensitivity to Thiotepa
Special Precautions while taking Thio-TEPA
1.Renal impairment
2.Hepatic impairment
3.Bone marrow depression
Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated
Children Related Information
Below 12 years:Contraindicated
Indications for Thio-TEPA
1.Breast cancer
2.Ovarian cancer
3.Hodgkin`s disease
4.Lymphoma
5.Bladder tumor
Interactions for Thio-TEPA
N/A
Typical Dosage for Thio-TEPA
IV
Adult: 0.2mg/kg daily for 4 - 5 days repeated every 2 - 4 weeks
Bladder tumor: 60mg in 30 - 60ml of Normal saline in bladder once weekly for 4 weeks
Children above 12years:same as adult dose
Schedule of Thio-TEPA
N/A
Storage Requirements for Thio-TEPA
Stored in the refrigerator at 2 to 8?C. Protect from light. Keep out of the reach of children
Effects of Missed Dosage of Thio-TEPA
The doctor should be informed immediately if a dose is missed
Effects of Overdose of Thio-TEPA
Give supportive measures and symptomatic treatment

Home Delivery for Thio-TEPA in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including thio-tepa.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for thio-tepa and other medicines and health products. Home delivery services for thio-tepa may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take thio-tepa only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for thio-tepa before they complete the sale. You can get this information while placing the order for thio-tepa with the pharmacy.

Thio-TEPA is a generic medicine name and there are several brands available for it. Some of the brands for thio-tepa might be better known than thio-tepa itself. If the pharmacy that's willing to deliver medicines to your home doesn't have thio-tepa in stock, you can ask for one of the branded alternatives for thio-tepa.