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- Pharmacology For Clotrimazole + Chlorhexidine
Clotrimazole + Chlorhexidine Pharmacology
Clotrimazole + Chlorhexidine
About Clotrimazole + ChlorhexidineN/AMechanism of Action of Clotrimazole + ChlorhexidineN/APharmacokinets of Clotrimazole + ChlorhexidineN/AOnset of Action for Clotrimazole + ChlorhexidineN/ADuration of Action for Clotrimazole + ChlorhexidineN/AHalf Life of Clotrimazole + ChlorhexidineN/ASide Effects of Clotrimazole + ChlorhexidineN/AContra-indications of Clotrimazole + ChlorhexidineN/ASpecial Precautions while taking Clotrimazole + ChlorhexidineN/APregnancy Related InformationContraindicated;since Chlorhexidine is contraindicated in pregnancy, the combination generic cannot be used in pregnancy.Old Age Related InformationN/ABreast Feeding Related InformationContraindicated;since Chlorhexidine is contraindicated in breast feeding, the combination generic cannot be used in breast feeding mother..Children Related InformationN/AIndications for Clotrimazole + ChlorhexidineFungal infectionInteractions for Clotrimazole + ChlorhexidineN/ATypical Dosage for Clotrimazole + ChlorhexidineApply the medicament to the affected area twice daily.Schedule of Clotrimazole + ChlorhexidineN/AStorage Requirements for Clotrimazole + ChlorhexidineN/AEffects of Missed Dosage of Clotrimazole + ChlorhexidineN/AEffects of Overdose of Clotrimazole + ChlorhexidineN/AClotrimazole
About ClotrimazoleA broad-spectrum antifungal antibiotic, imidazole derivative, Oral Nonabsorbed Antifungal Agent.Mechanism of Action of ClotrimazoleClotrimazole is fungicidal or fungistatic depending on the drug concentrations. It inhibits the conversion of Lanosterol to 14 demethyl Lanosterol by inhibiting the cytochromeP450 enzyme 14 alpha demethylase and impair ergosterol synthesis which is an essential constituent of cell membrane. Inhibition of ergosterol synthesis will alter the membrane permeability of the susceptible fungus and kill or inhibit them.Pharmacokinets of ClotrimazoleAbsorption: Absorption is minimal after topical administration.Onset of Action for ClotrimazoleN/ADuration of Action for Clotrimazole3 hoursHalf Life of ClotrimazoleN/ASide Effects of Clotrimazole1.Stinging
2.Erythema
3.Burning
4.Pruritis
5.Vesication
6.Desquamation
7.Urticaria
8.Burning
9.Peeling
10.Irritation
Contra-indications of ClotrimazoleHypersensitivity to ClotrimazoleSpecial Precautions while taking Clotrimazole1.Avoid contact with eyes, nose and mouth.
2.Do not wear occlusive dress over the medicament.
Pregnancy Related InformationUse with caution.Old Age Related InformationUse with caution.Breast Feeding Related InformationUse with caution.Children Related InformationUse with caution.
NEONATES: contraindicatedIndications for Clotrimazole1.Tinea pedis
2.Tinea cruris
3.Tinea versicolor
4.Tinea corporis
5.Cutaneous candidiasis
6.Vulvovaginal candidiasis
Interactions for ClotrimazolePolyene Antibiotics : Antagonises effects of polyene antibiotics.Typical Dosage for ClotrimazoleTopical: Clotrimazole cream, lotion and solution 1 % is used.
Clean and dry the affected area and apply the medicament with gentle massage 2 -3 times daily for 2 - 4 weeks.
Vaginal candidiasis: Insert 1 applicator full (vaginal cream 1%) intravaginally at night for 1 -2 weeks.
Vaginal tablets 100. 200 and 500mg tablet is available.
Vulvovaginal candidiasis: Insert 100mg tablet intravaginally at bed time for 7 consecutive days or 200 mg tablet for 3 consecutive days or 500 mg tablet for 1 day at night.
Oral lozenge 10 mg is available
Oropharyngeal candidiasis: 1 lozenge orally 5 times daily for 2 weeks
Prophylaxis of Oropharyngeal candidiasis: 1 lozenge is used 3 times daily
Gel: Insert with an applicator intravaginally at night for 1 - 2 weeks.
Powder (1% w/ w): dusted over the body parts as required
Schedule of ClotrimazoleHStorage Requirements for ClotrimazoleStore at room temperature (15 - 25 degree C). Protect from heat and moisture. Keep out of the reach of childrenEffects of Missed Dosage of ClotrimazoleApply the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of ClotrimazoleGive supportive measures and symptomatic treatment.Chlorhexidine
About ChlorhexidineA bisbiguanide antimicrobial agent, Anti-infective, antiseptic.Mechanism of Action of ChlorhexidineThis drug has positive charge so it attach to the negative charge cell wall. This destabilizes and destroys the integrity and penetrates bacterial cell membranes. It results precipitation of the cytoplasm and interferes with membrane function by inhibiting oxygen utilization leading to a decrease in cellular ATP levels and cell death. In gram-negative bacteria, chlorhexidine affects the outer membrane allowing the release of periplasmic enzymes. The inner membrane of these organisms is not ruptured but the uptake of small molecules is impaired. At low concentrations chlorhexidine exhibits a bacteriostatic effect while at high concentrations it is bactericidal.Pharmacokinets of ChlorhexidineAbsorption- Poorly from the gastrointestinal tract.
Distribution- 87% bound to the plasma proteins.
Excretion- Excreted through feces.
Onset of Action for ChlorhexidineN/ADuration of Action for ChlorhexidineN/AHalf Life of ChlorhexidineN/ASide Effects of Chlorhexidine1. Bleeding
2. Tender
3. Enlarged gums
4. Cough
5. Congestion or tightness in chest
6. Wheezing
7. Staining of teeth
8. Calculus formation above the gum line
Contra-indications of Chlorhexidine1. Hypersensitivity to the drugSpecial Precautions while taking Chlorhexidine1. Avoid eating or drinking for at least 1 hour after each dose
2. To minimize the staining apply drug with the hollow cup brush tip of the Rota-dent perio tool to only the gum tissue, especially focus on the areas with pockets depths over 4mm
3. You may also alternate drug with custom bleaching trays at home
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationUse with cautionIndications for Chlorhexidine1. Gingivitis
2. Acute and chronic otitis externa (ear infection/inflammation)
3. Periodontal disease
4. Superficial skin infections
5. Irrigation (cleansing) of wounds and as a medicated shampoo for the treatment of certain skin conditions (hot spots or acute moist dermatitis
Interactions for ChlorhexidineN/ATypical Dosage for ChlorhexidineOral rinse solutions - 0.1 percent.
Otic (ear) solutions - 1 percent.
Chlorhexidine solutions - 2 percent.
Chlorhexidine shampoo and conditioner 1 and 2 percent.
As an ear-cleansing agent - flush the ear canal once a day in cases of diagnosed otitis externa.
For skin conditions - clean the area twice daily.
For gingivitis - Chlorhexidine oral solution is applied as directed once a day. In the morning brush and floss for 2 minutes and than rinse with Chlorhexidine for 30 seconds.
Use 1/2 fl. oz. of undiluted. Swish in mouth for 30 seconds. After rinsing for 30 seconds be sure to spit out all the rinse, do NOT swallow any of the rinse. To minimize medicinal taste, DO NOT rinse with water immediately after use. In the evening brush and floss and rinse again for 30 seconds.
Chlorhexidine shampoo and conditioner - once or twice a week.
Pellet (extended-release), Periochip (in a biodegradable matrix of hydrolyzed gelatin cross-linked with glutaraldehyde), Cream, Dressing, Gel, Lotion, Ointment, Sponge forms are also available.
Schedule of ChlorhexidineN/AStorage Requirements for ChlorhexidineStore at room temperature below 77 degree F. Do not freeze.Effects of Missed Dosage of ChlorhexidineTake any missed dose as soon as possible but not if it is almost time for the next dose. If it is time for the next dose, skip the missed dose and resume your regular schedule. Do not "double-up" the dose.Effects of Overdose of ChlorhexidineGive symptomatic and supportive treatment.Home Delivery for Clotrimazole + Chlorhexidine in Your City
Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including clotrimazole + chlorhexidine.
However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for clotrimazole + chlorhexidine and other medicines and health products. Home delivery services for clotrimazole + chlorhexidine may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
Please be aware that you should take clotrimazole + chlorhexidine only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for clotrimazole + chlorhexidine before they complete the sale. You can get this information while placing the order for clotrimazole + chlorhexidine with the pharmacy.
Clotrimazole + Chlorhexidine is a generic medicine name and there are several brands available for it. Some of the brands for clotrimazole + chlorhexidine might be better known than clotrimazole + chlorhexidine itself. If the pharmacy that's willing to deliver medicines to your home doesn't have clotrimazole + chlorhexidine in stock, you can ask for one of the branded alternatives for clotrimazole + chlorhexidine.