Dinoprostone Pharmacology

Dinoprostone

About Dinoprostone
Naturally occurring prostaglandin E2, Abortifacient ,oxytocic, and antihemorrhagic.
Mechanism of Action of Dinoprostone
Dinoprostone (PGE2) causing the uterus to contract and the cervix to thin and dilate as occur during labour. It causes induction or augmentation of labour or mid term abortion.
Pharmacokinets of Dinoprostone
Absorption: Administered intra-vaginally, or in to cervical region. And also administer orally.
Onset of Action for Dinoprostone
N/A
Duration of Action for Dinoprostone
N/A
Half Life of Dinoprostone
N/A
Side Effects of Dinoprostone
1. Forceful uterine contractions
2. Haemorrhage
3. Vaginal irritations
4. Nausea
5. Vomiting
6. Dirrhoea
7. Amniotic fluid embolism
8. Post operative infections
9. Abdominal pain
10. Headache
11. Dizziness


Contra-indications of Dinoprostone
1. Hypersensitivity to prostaglandins
2. Pelvic inflammatory disease
3. Ruptured membranes
4. Malpresentation
5. Cephalopelvic disproportion
6. Grand multiparity
7. Suspected foetal compromise
8. Undiagnosed vaginal bleeding
9. Previous uterine surgery
10. Situations where vaginal delivery is not indicated as in herpes genitalis

Special Precautions while taking Dinoprostone
1. Pelvic infections
2. Cardiac disease
3. Renal impairment
4. Hepatic impairment
5. Lung disease
6. Asthma
7. Altered blood pressure
8. Diabetes
9. Seizure disorder
11. Infections in the vaginal area
12. Womb scarring

Pregnancy Related Information
Contraindicated
Old Age Related Information
N/A
Breast Feeding Related Information
Contraindicated
Children Related Information
N/A
Indications for Dinoprostone
1. To thin and widen cervical opening prior to labour
2. To cause the uterus to contract for labour
3. For uterus to contract to abort a pregnancy
Interactions for Dinoprostone
Oxytocics: Enhanced efficacy of oxytocics leading to uterine rupture.
Antiprogestins (Epostane, mefipristone): Enhance efficacy of Dinoprostone.
NSAIDs: Use the combination cautiously.
Oestrogen: Enhances cervical ripening and potentiates efficacy of Dinoprostone when used for therapeutic abortion.

Typical Dosage for Dinoprostone
Cervical gel: 0.5mg Dinoprostone in to the cervical canal.
Vaginal gel: 1mg Dinoprostone in to the vagina. Apply another 1 to 2mg; 6hours after the first dose as required.
Vaginal suppository :( for uterus to contract to abort a pregnancy): 10 to 20mg in to vagina every 3 to 5 hours as required.
Oral: 0.5mg hourly till induction up to the maximum dose of 1.5mg/hour.
Schedule of Dinoprostone
H
Storage Requirements for Dinoprostone
Store in a refrigerator in a well closed container. Keep out of reach of children.
Effects of Missed Dosage of Dinoprostone
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Dinoprostone
Provide symptomatic treatment and supportive measures.

Home Delivery for Dinoprostone in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including dinoprostone.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for dinoprostone and other medicines and health products. Home delivery services for dinoprostone may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take dinoprostone only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for dinoprostone before they complete the sale. You can get this information while placing the order for dinoprostone with the pharmacy.

Dinoprostone is a generic medicine name and there are several brands available for it. Some of the brands for dinoprostone might be better known than dinoprostone itself. If the pharmacy that's willing to deliver medicines to your home doesn't have dinoprostone in stock, you can ask for one of the branded alternatives for dinoprostone.