Carboprost Pharmacology

Carboprost

About Carboprost

Synthetic prostaglandin analogue of PGF2a (15-methyl-PGF2a), A systemic oxytocic agent.

Mechanism of Action of Carboprost

It is a synthetic prostaglandin (15-methyl PGF2 alpha). It binds the prostaglandin E2 receptor, causing myometrial contractions, causing the induction of labour or the expulsion of the placenta. They act on the muscles of the womb, causing them to contract.

Pharmacokinets of Carboprost

Metabolism- Metabolized in the lungs and liver to its metabolites
Excretion- Inactive metabolites are excreted in urine.

Onset of Action for Carboprost

N/A

Duration of Action for Carboprost

N/A

Half Life of Carboprost

N/A

Side Effects of Carboprost

1. Headache.
2. Dizziness.
3. Nausea.
4. Vomiting.
5. Cardiac arrest.
6. Wheezing.
7. Redness around injection site.
8. Diarrhoea.
9. Facial flushing.
10. Increase in body temperature.
11. Hypertension.
12. Pulmonary oedema

Contra-indications of Carboprost

1. Hypersensitivity to the drug.
2. Cardiovascular diseases.
3. Kidney disease.
4. Liver disease.
5. Lung disease.
6. Recent infection of the ovaries, fallopian tubes and uterus

Special Precautions while taking Carboprost

1. Anemia.
2. Asthma.
3. Diabetes.
4. Epilepsy.
5. Glaucoma.
6. High blood pressure.
7. Jaundice.
8. Hypotension.
9. Scarring of the womb.

Pregnancy Related Information

Use with caution.

Old Age Related Information

Not applicable.

Breast Feeding Related Information

Not applicable.

Children Related Information

Not applicable.

Indications for Carboprost

1. Bleeding after birth (post-partum) due to lack of uterine muscle tone
2. Termination of pregnancy in the second trimester
3. Hemorrhagic cystitis in stem cell transplant recipients

Interactions for Carboprost

Oxytocin: Activity of oxytocin augmented and hence should be used sequentially and carefully monitored.
Hyperosmolar Urea: Prior injection of urea enhances activity of carboprost.
Mifepristone: Enhanced activity with fewer side effects.

Typical Dosage for Carboprost

Intramuscular-
Adults-
Termination of pregnancy:
250 mcg at intervals of 1.5-3.5 hours, depending on uterine response; may increase dose to 500 mcg if contractility is inadequate after several 250 mcg doses. Dose should not exceed 2 mg
Control of hemorrhage:
250 mcg; additional doses may be administered between 15 and 90 minutes apart if needed. Dose should not exceed 2 mg
Catheterization-
Hemorrhagic Cystitis:
400-500mcg diluted in 50mL NS and instilled into the bladder; clamp catheter and allow solution to dwell for 60 minutes; repeat every 6 hours until response. Patient should change positions every 15 minutes while carboprost is in bladder

Schedule of Carboprost

Storage Requirements for Carboprost

Store the drug at 2 - 4 degree C.

Effects of Missed Dosage of Carboprost

Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose

Effects of Overdose of Carboprost

Give symptomatic and supportive treatment.

Home Delivery for Carboprost in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including carboprost.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for carboprost and other medicines and health products. Home delivery services for carboprost may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take carboprost only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for carboprost before they complete the sale. You can get this information while placing the order for carboprost with the pharmacy.

Carboprost is a generic medicine name and there are several brands available for it. Some of the brands for carboprost might be better known than carboprost itself. If the pharmacy that's willing to deliver medicines to your home doesn't have carboprost in stock, you can ask for one of the branded alternatives for carboprost.