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- Pharmacology For Valdecoxib + Paracetamol
Valdecoxib + Paracetamol Pharmacology
Valdecoxib + Paracetamol
About Valdecoxib + ParacetamolN/AMechanism of Action of Valdecoxib + ParacetamolN/APharmacokinets of Valdecoxib + ParacetamolN/AOnset of Action for Valdecoxib + ParacetamolN/ADuration of Action for Valdecoxib + ParacetamolN/AHalf Life of Valdecoxib + ParacetamolN/ASide Effects of Valdecoxib + ParacetamolN/AContra-indications of Valdecoxib + ParacetamolN/ASpecial Precautions while taking Valdecoxib + ParacetamolN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Valdecoxib + ParacetamolN/AInteractions for Valdecoxib + ParacetamolN/ATypical Dosage for Valdecoxib + ParacetamolN/ASchedule of Valdecoxib + ParacetamolN/AStorage Requirements for Valdecoxib + ParacetamolN/AEffects of Missed Dosage of Valdecoxib + ParacetamolN/AEffects of Overdose of Valdecoxib + ParacetamolN/AValdecoxib
About ValdecoxibNSAID,a COX-2 inhibitor, a diaryl substituted isoxazole, Analgesic,antiinflammatory,antiarthritic.Mechanism of Action of ValdecoxibThis NSAID inhibit COX2 enzyme selectively (COX-2 is only produced in response to tissue injury and causes tissue inflammation, and thus pain. It works by converting arachidonic acid into a specific prostaglandin which communicates the need for inflammation to the surrounding tissue). This results the anti-inflammatory action.
Pharmacokinets of ValdecoxibAbsorption- Well absorbed after oral administration.
Distribution- Widely distributed in the body as its plasma protein bound form. 98% bound to the plasma proteins.
Metabolism-It is metabolized in the liver.
Excretion- Excreted through urine and faeces.
Onset of Action for ValdecoxibN/ADuration of Action for ValdecoxibN/AHalf Life of ValdecoxibN/ASide Effects of Valdecoxib1. Diarrhea
2. Constipation
3. Sore throat
4. Cough
5. Runny nose
6. Fever
7. Blisters
8. Hives
9. Itching
10. Swelling of the eyes, face, tongue, lips, throat, arms, hands, feet, ankles, or lower legs
11. Difficulty in breathing or swallowing
12. Hoarseness
13. Pale skin
14. Fast heartbeat
15. Weight gain
16. Upset stomach
17. Tiredness
18. Pain in the right upper part of the stomach
19. Flu-like symptoms
20. Cloudy, discolored, or bloody urine
21. Back pain
22. Difficult or painful urination
Contra-indications of Valdecoxib1. Hypersensitivity to the drug
2. Hepatic insufficiency
3. Renal insufficiency
Special Precautions while taking Valdecoxib1. Alcohol abuse
2. Bleeding problems
3. Stomach ulcer
4. Tobacco abuse
5. Anemia
6. Asthma
7. Dehydration
8. Fluid retention (swelling of feet or lower legs)
9. High blood pressure
10. Kidney disease
11. Liver disease
12. Coronary artery bypass graft (CABG) surgery
13. Heart disease
Pregnancy Related InformationContraindicated
Old Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationContraindicatedIndications for Valdecoxib1. Dysmenorrhea (pain with your menstrual period)
2. Osteoarthritis
3. Rheumatoid arthritis
4. Acute gout
Interactions for ValdecoxibCoadministration with fluconazole and ketoconazole : Enhances the total plasma exposure (AUC) of valdecoxib.
Coadministration with warfarin: Causes a significant increase in plasma exposure of warfarin.
Typical Dosage for ValdecoxibOral-
Adults-
Osteoarthritis & rheumatoid arthritis - 10mg once a day.
Dysmenorrhea- 20- 40mg daily.
Schedule of ValdecoxibN/AStorage Requirements for ValdecoxibStore at room temperature away from moisture and heat.Effects of Missed Dosage of ValdecoxibTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of ValdecoxibGive symptomatic and supportive treatment. Induce gastric emesis and administer activated charcoal to reduce further adsorption of drugs.Paracetamol
About ParacetamolAcetanilide derivative, Non narcotic Analgesic,Antipyretic.Mechanism of Action of ParacetamolParacetamol has analgesic and antipyretic action.
It is more active on cyclo-oxygenase enzyme in brain. Peripherally it is a poor inhibitor of prostaglandin synthesis.
Analgesic action: Paracetamol raises the pain threshold and produces analgesic effect.
Antipyretic action: Paracetamol lowers fever by direct action on the thermoregulatory centre in the Hypothalamus and block the effects of endogenous pyrogen.
Pharmacokinets of ParacetamolAbsorption: Paracetamol is rapidly and completely absorbed after oral administration.
Distribution: It is distributed mostly in the body in unbound form.
Metabolism: It is extensively metabolised in the liver.
Excretion: Excreted in the urine.
Onset of Action for Paracetamol30 - 60 minutesDuration of Action for Paracetamol6 hoursHalf Life of Paracetamol1-4 hoursSide Effects of Paracetamol1. Nausea
2. Abdominal distress
3. Allergic reactions
4. Rash
Contra-indications of Paracetamol1. Hypersensitivity to ParacetamolSpecial Precautions while taking Paracetamol1. Hepatic impairment
2. Renal impairment
3. Hypertension
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with caution
NEONATES : Contraindicated
Indications for Paracetamol1. To relieve pain and fever
2. Acute gout
3. Migraine
Interactions for ParacetamolCholestyramine: Reduces absorption of paracetamol.
Charcoal: Activated, administered immediately reduces absorption of paracetamol.
Domperidone and metochlopramide: Enhance absorption of paracetamol.
Alcohol: Chronic excessive ingestion of alcohol potentiates hepatotoxicity of paracetamol.
Zidovudine: Effects zidovudine may be decreased.Typical Dosage for ParacetamolAdult:
500 - 1000 mg in 3 times daily
Maximum dose: 4 g / day
For migraine: 500 mg to be taken at the first sign of migraine attack and repeated 4 - 6 hourly until suppress mild attacks.
Children:
60 mg / kg body weight /day in 4 divided doses.
Schedule of ParacetamolHStorage Requirements for ParacetamolStore at 15-30 degree C in a tightly closed container. Protect from heat and moisture. Keep out of the reach of children.Effects of Missed Dosage of ParacetamolTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of ParacetamolGive supportive measures and symptomatic treatment. Drug can be removed from the body by gastric lavage or by inducing emesis. Absorption of the drug can be reduced by administration of activated charcoal. N-acetylcysteine is the specific antidote for Paracetamol poisoning. Dose: 150 mg /kg body weight as IV infusion over 15 minutes followed by same dose over 20 hours.
Maintenance dose: 75 mg / kg orally every 4 - 6 hours for 2 - 3 days. Haemodialysis can be done in emergency conditions.
Home Delivery for Valdecoxib + Paracetamol in Your City
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Valdecoxib + Paracetamol is a generic medicine name and there are several brands available for it. Some of the brands for valdecoxib + paracetamol might be better known than valdecoxib + paracetamol itself. If the pharmacy that's willing to deliver medicines to your home doesn't have valdecoxib + paracetamol in stock, you can ask for one of the branded alternatives for valdecoxib + paracetamol.