- Medicine India
- Generic Medicines
- B
- Pharmacology For Beclomethasone dipropionate + Ofloxacin + Clotrimazole
Beclomethasone dipropionate + Ofloxacin + Clotrimazole Pharmacology
Beclomethasone dipropionate + Ofloxacin + Clotrimazole
About Beclomethasone dipropionate + Ofloxacin + ClotrimazoleN/AMechanism of Action of Beclomethasone dipropionate + Ofloxacin + ClotrimazoleN/APharmacokinets of Beclomethasone dipropionate + Ofloxacin + ClotrimazoleN/AOnset of Action for Beclomethasone dipropionate + Ofloxacin + ClotrimazoleN/ADuration of Action for Beclomethasone dipropionate + Ofloxacin + ClotrimazoleN/AHalf Life of Beclomethasone dipropionate + Ofloxacin + ClotrimazoleN/ASide Effects of Beclomethasone dipropionate + Ofloxacin + ClotrimazoleN/AContra-indications of Beclomethasone dipropionate + Ofloxacin + ClotrimazoleN/ASpecial Precautions while taking Beclomethasone dipropionate + Ofloxacin + ClotrimazoleN/APregnancy Related InformationContraindicated; since Ofloxacin is contraindicated in pregnancy, the combination generic cannot be used in pregnancy.Old Age Related InformationN/ABreast Feeding Related InformationContraindicated; since Ofloxacin is contraindicated in breast feeding, the combination generic cannot be used in breast feeding motherChildren Related InformationN/AIndications for Beclomethasone dipropionate + Ofloxacin + Clotrimazole1.Fungal infection of ear(otitis externa)Interactions for Beclomethasone dipropionate + Ofloxacin + ClotrimazoleN/ATypical Dosage for Beclomethasone dipropionate + Ofloxacin + ClotrimazoleApply 2 -3 drop in to the ear 2 - 3 times daily.Schedule of Beclomethasone dipropionate + Ofloxacin + ClotrimazoleN/AStorage Requirements for Beclomethasone dipropionate + Ofloxacin + ClotrimazoleN/AEffects of Missed Dosage of Beclomethasone dipropionate + Ofloxacin + ClotrimazoleN/AEffects of Overdose of Beclomethasone dipropionate + Ofloxacin + ClotrimazoleN/ABeclomethasone dipropionate
About Beclomethasone dipropionatePotent glucocorticoid, Potent anti-inflammatory agent in respiratory tract and nasal passages.Mechanism of Action of Beclomethasone dipropionateMechanism of action: The drug exerts its pharmacological action by penetrating and binding to cytoplasmic receptor protein and causes a structural change in steroid receptor complex. This structural change allows it`s migration in to the nucleus and then binding to specific sites on the DNA which leads to transcription of specific m-RNA and which ultimately regulates protein synthesis. It exerts highly selective glucocorticoid action. It stimulates the enzymes needed to decrease the inflammatory response.
The drug exerts anti-inflammatory and immunosuppressant actions as follows: - 1) Induce lipocortins in macrophages, endothelium, and fibroblasts which inhibits Phospholipase A2 and thus decreases the production of Prostaglandins, leukotrienes (LT), and platelet activating factor, 2) Causes negative regulation of genes for cytokines in macrophages, endothelial cells and lymphocytes and thus decreases the production of interleukins (IL-1, IL-2, IL-3, IL-6), TNF-alpha, GM-CSF (granulocyte macrophage colony stimulating factor), Gama interferon and suppresses fibroblast proliferation and T-lymphocyte functions and interferes chemo taxis. 3) Decreases the production of acute phase reactants from macrophages and endothelial cells and interferes complement function. 4) Decreases the production of ELAM-1(Endothelial leukocyte adhesion molecule-1) and ICAM-1(intracellular adhesion molecule-1) in endothelial cells. 5) Inhibit IgE mediated histamine and LT-C4 release from basophiles and the effects of antigen-antibody reaction is not mediated 6) Reduces the production of collagenase and stromolysin and thus prevents tissue destruction.
Pharmacokinets of Beclomethasone dipropionateAbsorption: It enters in to the systemic circulation after topical administration.Onset of Action for Beclomethasone dipropionateN/ADuration of Action for Beclomethasone dipropionateN/AHalf Life of Beclomethasone dipropionateN/ASide Effects of Beclomethasone dipropionate1.Thinning of the skin
2.Loss of elasticity
3.Increased hair growth
4.Acne at the site of application
5.Mild depigmentation
6.Rosacea
Contra-indications of Beclomethasone dipropionate1.Hypersensitivity to Beclomethasone
2.Untreated bacterial virus or fungal infections
3.Acne vulgaris
4.Peri-oral dermatitis
5.Tuberculosis of the skin
6.Varicose ulcers
7.Skin lesions caused by infections with herpes simplex vaccinia or varicella viruses. fungi (e.g. Candida Tinea) or bacteria (e.g. impetigo)
8.Discoid lupus Erythematosus
Special Precautions while taking Beclomethasone dipropionate1.Avoid contact with eyes
2.For external use only
3.Prolonged use
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with caution
NEONATES: contraindicatedIndications for Beclomethasone dipropionate1.Eczema
2.Psoriasis
3.Contact dermatitis
4.Anal and vulval Pruritis
5.Inflammation of the skin
Interactions for Beclomethasone dipropionateThere are no known drug interactions with topical betamethasone dipropionate.
Typical Dosage for Beclomethasone dipropionateTopical: Apply 0.025 %w/w cream as thin film 1 - 2times daily on to the affected areaSchedule of Beclomethasone dipropionateHStorage Requirements for Beclomethasone dipropionateStore below 25 degree C in a tightly closed container. Keep out of the reach of childrenEffects of Missed Dosage of Beclomethasone dipropionateApply the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Beclomethasone dipropionateGive supportive measures and symptomatic treatment.Ofloxacin
About OfloxacinA second generation fluoroquinolone(quinolones), Antibiotic.Mechanism of Action of OfloxacinOfloxacin is a bactericidal drug. It act by inhibiting the enzyme DNA gyrase (Topoisomerase 2) and Topoisomerase 4.DNA gyrase helps in the formation of a highly condensed three dimensional structure of the DNA by its nicking and closing activity and also by introducing negative supercoil in to the DNA double helix. Ofloxacin inhibits DNA gyrase which results in abnormal linkage between opened DNA and gyrase and negative supercoiling is also impaired. This will inhibits transcription of DNA in to RNA and subsequent protein synthesis.Pharmacokinets of OfloxacinAbsorption: Ofloxacin is rapidly and completely absorbed after oral administration.
Distribution: It is widely distributed in the body.
Metabolism: It undergoes insignificant metabolism.
Excretion: Drug is excreted mainly through urine.
Onset of Action for OfloxacinWith in 0.5 hour Duration of Action for Ofloxacin12 - 16 hoursHalf Life of Ofloxacin5 - 8 hoursSide Effects of Ofloxacin1. Nausea
2. Vomiting
3. Diarrhoea
4. Abdominal discomfort
5. Constipation
6. Dry mouth
7. Dizziness
8. Headache
9. Rash
10. Pruritis
11. Pseudomembranous colitis
12. Visual disturbances
13. Insomnia
Contra-indications of Ofloxacin1. Hypersensitivity to Ofloxacin and other FluoroquinolonesSpecial Precautions while taking Ofloxacin1. Hepatic impairment
2. Renal impairment
3. Cerebral arteriosclerosis
4. Epilepsy
5. CNS disease
6. Avoid exposure to sunlight
7. Caution while driving the vehicle or operating machine or involved in any hazardous activities.
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationContraindicated
NEONATES : Contraindicated
Indications for Ofloxacin1. Bronchitis
2. Pneumonia
3. Urinary tract infection
4. Bone and joint infections
5. Intra-abdominal infections
6. Gonorrhoea
7. ENT infections
8. Skin and soft tissue infections
9. Typhoid fever
10. Prostatis
11. Otitis
12. Gynaecological infections
13. Conjunctivitis
14. Keratitis
15. Urethritis
16. CervicitisInteractions for OfloxacinOral Anticoagulants: The effects of oral anticoagulants, may be increased.
Theophylline: Increased plasma levels of theophylline resulting in toxicity.
NSAID`s: CNS excitation may occur.Typical Dosage for OfloxacinAdults: 200 - 400 mg / day depending on the severity and type of infection
Bronchitis, Pneumonia, Skin and soft tissue infections: 800 mg / day in 2 divided doses for 10 days
Gonorrhoea: 400 mg as a single dose.
Prostatis, Cervicitis & Urethritis: 600 mg / day in 2 divided doses for 1 week.
UTI: 200 - 800 mg / day in single or divided doses
Typhoid fever: 400 - 800 mg / day in 2 divided doses
Schedule of OfloxacinHStorage Requirements for OfloxacinStore at 15 - 30 degree C in a tightly closed container.Effects of Missed Dosage of OfloxacinTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose.Effects of Overdose of OfloxacinGive supportive measures and symptomatic treatment. Gastric lavage has to be done. Clotrimazole
About ClotrimazoleA broad-spectrum antifungal antibiotic, imidazole derivative, Oral Nonabsorbed Antifungal Agent.Mechanism of Action of ClotrimazoleClotrimazole is fungicidal or fungistatic depending on the drug concentrations. It inhibits the conversion of Lanosterol to 14 demethyl Lanosterol by inhibiting the cytochromeP450 enzyme 14 alpha demethylase and impair ergosterol synthesis which is an essential constituent of cell membrane. Inhibition of ergosterol synthesis will alter the membrane permeability of the susceptible fungus and kill or inhibit them.Pharmacokinets of ClotrimazoleAbsorption: Absorption is minimal after topical administration.Onset of Action for ClotrimazoleN/ADuration of Action for Clotrimazole3 hoursHalf Life of ClotrimazoleN/ASide Effects of Clotrimazole1.Stinging
2.Erythema
3.Burning
4.Pruritis
5.Vesication
6.Desquamation
7.Urticaria
8.Burning
9.Peeling
10.Irritation
Contra-indications of ClotrimazoleHypersensitivity to ClotrimazoleSpecial Precautions while taking Clotrimazole1.Avoid contact with eyes, nose and mouth.
2.Do not wear occlusive dress over the medicament.
Pregnancy Related InformationUse with caution.Old Age Related InformationUse with caution.Breast Feeding Related InformationUse with caution.Children Related InformationUse with caution.
NEONATES: contraindicatedIndications for Clotrimazole1.Tinea pedis
2.Tinea cruris
3.Tinea versicolor
4.Tinea corporis
5.Cutaneous candidiasis
6.Vulvovaginal candidiasis
Interactions for ClotrimazolePolyene Antibiotics : Antagonises effects of polyene antibiotics.Typical Dosage for ClotrimazoleTopical: Clotrimazole cream, lotion and solution 1 % is used.
Clean and dry the affected area and apply the medicament with gentle massage 2 -3 times daily for 2 - 4 weeks.
Vaginal candidiasis: Insert 1 applicator full (vaginal cream 1%) intravaginally at night for 1 -2 weeks.
Vaginal tablets 100. 200 and 500mg tablet is available.
Vulvovaginal candidiasis: Insert 100mg tablet intravaginally at bed time for 7 consecutive days or 200 mg tablet for 3 consecutive days or 500 mg tablet for 1 day at night.
Oral lozenge 10 mg is available
Oropharyngeal candidiasis: 1 lozenge orally 5 times daily for 2 weeks
Prophylaxis of Oropharyngeal candidiasis: 1 lozenge is used 3 times daily
Gel: Insert with an applicator intravaginally at night for 1 - 2 weeks.
Powder (1% w/ w): dusted over the body parts as required
Schedule of ClotrimazoleHStorage Requirements for ClotrimazoleStore at room temperature (15 - 25 degree C). Protect from heat and moisture. Keep out of the reach of childrenEffects of Missed Dosage of ClotrimazoleApply the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of ClotrimazoleGive supportive measures and symptomatic treatment.Home Delivery for Beclomethasone dipropionate + Ofloxacin + Clotrimazole in Your City
Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including beclomethasone dipropionate + ofloxacin + clotrimazole.
However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for beclomethasone dipropionate + ofloxacin + clotrimazole and other medicines and health products. Home delivery services for beclomethasone dipropionate + ofloxacin + clotrimazole may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
Please be aware that you should take beclomethasone dipropionate + ofloxacin + clotrimazole only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for beclomethasone dipropionate + ofloxacin + clotrimazole before they complete the sale. You can get this information while placing the order for beclomethasone dipropionate + ofloxacin + clotrimazole with the pharmacy.
Beclomethasone dipropionate + Ofloxacin + Clotrimazole is a generic medicine name and there are several brands available for it. Some of the brands for beclomethasone dipropionate + ofloxacin + clotrimazole might be better known than beclomethasone dipropionate + ofloxacin + clotrimazole itself. If the pharmacy that's willing to deliver medicines to your home doesn't have beclomethasone dipropionate + ofloxacin + clotrimazole in stock, you can ask for one of the branded alternatives for beclomethasone dipropionate + ofloxacin + clotrimazole.