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- Pharmacology For Beclomethasone dipropionate + Gentamicin (Eye/Ear Drops)+ Clotrimazole (Ear Drops)
Beclomethasone dipropionate + Gentamicin (Eye/Ear Drops)+ Clotrimazole (Ear Drops) Pharmacology
Beclomethasone dipropionate + Gentamicin (Eye/Ear Drops)+ Clotrimazole (Ear Drops)
About Beclomethasone dipropionate + Gentamicin (Eye/Ear Drops)+ Clotrimazole (Ear Drops)N/AMechanism of Action of Beclomethasone dipropionate + Gentamicin (Eye/Ear Drops)+ Clotrimazole (Ear Drops)N/APharmacokinets of Beclomethasone dipropionate + Gentamicin (Eye/Ear Drops)+ Clotrimazole (Ear Drops)N/AOnset of Action for Beclomethasone dipropionate + Gentamicin (Eye/Ear Drops)+ Clotrimazole (Ear Drops)N/ADuration of Action for Beclomethasone dipropionate + Gentamicin (Eye/Ear Drops)+ Clotrimazole (Ear Drops)N/AHalf Life of Beclomethasone dipropionate + Gentamicin (Eye/Ear Drops)+ Clotrimazole (Ear Drops)N/ASide Effects of Beclomethasone dipropionate + Gentamicin (Eye/Ear Drops)+ Clotrimazole (Ear Drops)N/AContra-indications of Beclomethasone dipropionate + Gentamicin (Eye/Ear Drops)+ Clotrimazole (Ear Drops)N/ASpecial Precautions while taking Beclomethasone dipropionate + Gentamicin (Eye/Ear Drops)+ Clotrimazole (Ear Drops)N/APregnancy Related InformationContraindicated; since Gentamicin is contraindicated in pregnancy, the combination generic cannot be used in pregnancy.Old Age Related InformationN/ABreast Feeding Related InformationContraindicated; since Gentamicin is contraindicated in breast feeding, the combination generic cannot be used in breast feeding motherChildren Related InformationN/AIndications for Beclomethasone dipropionate + Gentamicin (Eye/Ear Drops)+ Clotrimazole (Ear Drops)1.Fungal infection of ear (otitis externa)Interactions for Beclomethasone dipropionate + Gentamicin (Eye/Ear Drops)+ Clotrimazole (Ear Drops)N/ATypical Dosage for Beclomethasone dipropionate + Gentamicin (Eye/Ear Drops)+ Clotrimazole (Ear Drops)Apply 2 -3 drop in to the ear 2 - 3 times daily.Schedule of Beclomethasone dipropionate + Gentamicin (Eye/Ear Drops)+ Clotrimazole (Ear Drops)N/AStorage Requirements for Beclomethasone dipropionate + Gentamicin (Eye/Ear Drops)+ Clotrimazole (Ear Drops)N/AEffects of Missed Dosage of Beclomethasone dipropionate + Gentamicin (Eye/Ear Drops)+ Clotrimazole (Ear Drops)N/AEffects of Overdose of Beclomethasone dipropionate + Gentamicin (Eye/Ear Drops)+ Clotrimazole (Ear Drops)N/ABeclomethasone dipropionate
About Beclomethasone dipropionatePotent glucocorticoid, Potent anti-inflammatory agent in respiratory tract and nasal passages.Mechanism of Action of Beclomethasone dipropionateMechanism of action: The drug exerts its pharmacological action by penetrating and binding to cytoplasmic receptor protein and causes a structural change in steroid receptor complex. This structural change allows it`s migration in to the nucleus and then binding to specific sites on the DNA which leads to transcription of specific m-RNA and which ultimately regulates protein synthesis. It exerts highly selective glucocorticoid action. It stimulates the enzymes needed to decrease the inflammatory response.
The drug exerts anti-inflammatory and immunosuppressant actions as follows: - 1) Induce lipocortins in macrophages, endothelium, and fibroblasts which inhibits Phospholipase A2 and thus decreases the production of Prostaglandins, leukotrienes (LT), and platelet activating factor, 2) Causes negative regulation of genes for cytokines in macrophages, endothelial cells and lymphocytes and thus decreases the production of interleukins (IL-1, IL-2, IL-3, IL-6), TNF-alpha, GM-CSF (granulocyte macrophage colony stimulating factor), Gama interferon and suppresses fibroblast proliferation and T-lymphocyte functions and interferes chemo taxis. 3) Decreases the production of acute phase reactants from macrophages and endothelial cells and interferes complement function. 4) Decreases the production of ELAM-1(Endothelial leukocyte adhesion molecule-1) and ICAM-1(intracellular adhesion molecule-1) in endothelial cells. 5) Inhibit IgE mediated histamine and LT-C4 release from basophiles and the effects of antigen-antibody reaction is not mediated 6) Reduces the production of collagenase and stromolysin and thus prevents tissue destruction.
Pharmacokinets of Beclomethasone dipropionateAbsorption: It enters in to the systemic circulation after topical administration.Onset of Action for Beclomethasone dipropionateN/ADuration of Action for Beclomethasone dipropionateN/AHalf Life of Beclomethasone dipropionateN/ASide Effects of Beclomethasone dipropionate1.Thinning of the skin
2.Loss of elasticity
3.Increased hair growth
4.Acne at the site of application
5.Mild depigmentation
6.Rosacea
Contra-indications of Beclomethasone dipropionate1.Hypersensitivity to Beclomethasone
2.Untreated bacterial virus or fungal infections
3.Acne vulgaris
4.Peri-oral dermatitis
5.Tuberculosis of the skin
6.Varicose ulcers
7.Skin lesions caused by infections with herpes simplex vaccinia or varicella viruses. fungi (e.g. Candida Tinea) or bacteria (e.g. impetigo)
8.Discoid lupus Erythematosus
Special Precautions while taking Beclomethasone dipropionate1.Avoid contact with eyes
2.For external use only
3.Prolonged use
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with caution
NEONATES: contraindicatedIndications for Beclomethasone dipropionate1.Eczema
2.Psoriasis
3.Contact dermatitis
4.Anal and vulval Pruritis
5.Inflammation of the skin
Interactions for Beclomethasone dipropionateThere are no known drug interactions with topical betamethasone dipropionate.
Typical Dosage for Beclomethasone dipropionateTopical: Apply 0.025 %w/w cream as thin film 1 - 2times daily on to the affected areaSchedule of Beclomethasone dipropionateHStorage Requirements for Beclomethasone dipropionateStore below 25 degree C in a tightly closed container. Keep out of the reach of childrenEffects of Missed Dosage of Beclomethasone dipropionateApply the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Beclomethasone dipropionateGive supportive measures and symptomatic treatment.Gentamicin (Eye/Ear Drops)
About Gentamicin (Eye/Ear Drops)It is an aminoglycoside antiinfective preparation.Mechanism of Action of Gentamicin (Eye/Ear Drops)Gentamicin exerts its bactericidal action against gram- negative organisms & some of gram positive organisms by inhibiting bacterial protein synthesis. The process involves 1.Penetration of bacterial cell membrane & binding directly to the bacterial ribosome, 2.Misleading of m-RNA codon by bacterial ribosome, 3.Formation of peptide chains with wrong amino acid sequence which gets incorporated into bacterial cell membrane and alters its permeability, 4.Bacterial cell lysis. Some bacterial strains resistant to other amino glycosides are sensitive to GentamicinPharmacokinets of Gentamicin (Eye/Ear Drops)Absorption: Only a very small amount of the drug enter in to the systemic circulationOnset of Action for Gentamicin (Eye/Ear Drops)N/ADuration of Action for Gentamicin (Eye/Ear Drops)N/AHalf Life of Gentamicin (Eye/Ear Drops)N/ASide Effects of Gentamicin (Eye/Ear Drops)1.Burning
2.Irritation
3.Itching
4.Swelling
5.Redness
6.Pain in or around the eyes or ears
7.Hearing loss
8.Ringing in the ear
9.Dizziness
10.Loss of coordination
11.Stinging
Contra-indications of Gentamicin (Eye/Ear Drops)1. Hypersensitivity to GentamicinSpecial Precautions while taking Gentamicin (Eye/Ear Drops)1. Prolonged use
2. If irritation occurs then discontinue the use of medicaments
3. Avoid contact lenses
Pregnancy Related InformationEYE DROPS: EAR DROPS:
Use with caution Contraindicated
Old Age Related InformationEYE DROPS: EAR DROPS:
Use with caution Use with cautionBreast Feeding Related InformationEYE DROPS: EAR DROPS:
Use with caution ContraindicatedChildren Related InformationEYE DROPS: EAR DROPS:
Use with caution Use with caution
NEONATES:
EYE DROPS: EAR DROPS:
Contraindicated ContraindicatedIndications for Gentamicin (Eye/Ear Drops)1.Bacterial Otitis externa
2.External ocular infections
Interactions for Gentamicin (Eye/Ear Drops)N/ATypical Dosage for Gentamicin (Eye/Ear Drops)Gentamicin 0.3% w/v solution is available.
Eyes: 1 or 2 drops should be instilled in the affected eye up to 3 - 4 times a day, or more times if required and then reduce the dose until the infection is controlled
Ears: The area should be cleaned and 2 - 3 drops instilled in the affected ear three to four times a day and at night, or more frequently if required.
Schedule of Gentamicin (Eye/Ear Drops)N/AStorage Requirements for Gentamicin (Eye/Ear Drops)Store at cool dry place. Do not freeze. Keep out of the reach of childrenEffects of Missed Dosage of Gentamicin (Eye/Ear Drops)Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Gentamicin (Eye/Ear Drops)Give supportive measures and symptomatic treatment. The exposed eye should be irrigated with copious amounts of water for at least 15 minutes. Clotrimazole (Ear Drops)
About Clotrimazole (Ear Drops)A broad-spectrum antifungal antibiotic, imidazole derivative, Antifungal in otitis externa and otomycoses.Mechanism of Action of Clotrimazole (Ear Drops)Clotrimazole is fungicidal or fungistatic depending on the drug concentrations. It inhibits the conversion of Lanosterol to 14 demethyl Lanosterol by inhibiting the cytochromeP450 enzyme 14 alpha demethylase and impair ergosterol synthesis. This will alter the membrane permeability of the susceptible fungusPharmacokinets of Clotrimazole (Ear Drops)N/AOnset of Action for Clotrimazole (Ear Drops)N/ADuration of Action for Clotrimazole (Ear Drops)N/AHalf Life of Clotrimazole (Ear Drops)N/ASide Effects of Clotrimazole (Ear Drops)1.Local irritationContra-indications of Clotrimazole (Ear Drops)Perforation of tympanic membrane.Special Precautions while taking Clotrimazole (Ear Drops)1. Not for ophthalmic use
2. HypersensitivityPregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Clotrimazole (Ear Drops)1. Fungal infections of Otitis externaInteractions for Clotrimazole (Ear Drops)N/ATypical Dosage for Clotrimazole (Ear Drops)Ear drops: 1%w/v Clotrimazole solution is used.
Adult: Instill 2 - 3 drops 6- 8 hourly for 2 weeks.
Schedule of Clotrimazole (Ear Drops)N/AStorage Requirements for Clotrimazole (Ear Drops)Store at cool dry place. Do not freeze. Keep out of the reach of childrenEffects of Missed Dosage of Clotrimazole (Ear Drops)Instill the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Clotrimazole (Ear Drops)Give supportive measures and symptomatic treatment. Home Delivery for Beclomethasone dipropionate + Gentamicin (Eye/Ear Drops)+ Clotrimazole (Ear Drops) in Your City
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Beclomethasone dipropionate + Gentamicin (Eye/Ear Drops)+ Clotrimazole (Ear Drops) is a generic medicine name and there are several brands available for it. Some of the brands for beclomethasone dipropionate + gentamicin (eye/ear drops)+ clotrimazole (ear drops) might be better known than beclomethasone dipropionate + gentamicin (eye/ear drops)+ clotrimazole (ear drops) itself. If the pharmacy that's willing to deliver medicines to your home doesn't have beclomethasone dipropionate + gentamicin (eye/ear drops)+ clotrimazole (ear drops) in stock, you can ask for one of the branded alternatives for beclomethasone dipropionate + gentamicin (eye/ear drops)+ clotrimazole (ear drops).