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- Pharmacology For Adapalene + Clindamycin Topical
Adapalene + Clindamycin Topical Pharmacology
Adapalene + Clindamycin Topical
About Adapalene + Clindamycin TopicalN/AMechanism of Action of Adapalene + Clindamycin TopicalN/APharmacokinets of Adapalene + Clindamycin TopicalN/AOnset of Action for Adapalene + Clindamycin TopicalN/ADuration of Action for Adapalene + Clindamycin TopicalN/AHalf Life of Adapalene + Clindamycin TopicalN/ASide Effects of Adapalene + Clindamycin TopicalN/AContra-indications of Adapalene + Clindamycin TopicalN/ASpecial Precautions while taking Adapalene + Clindamycin TopicalN/APregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationN/AIndications for Adapalene + Clindamycin TopicalAcne vulgarisInteractions for Adapalene + Clindamycin TopicalN/ATypical Dosage for Adapalene + Clindamycin TopicalApply the medicament once dailySchedule of Adapalene + Clindamycin TopicalN/AStorage Requirements for Adapalene + Clindamycin TopicalN/AEffects of Missed Dosage of Adapalene + Clindamycin TopicalN/AEffects of Overdose of Adapalene + Clindamycin TopicalN/AAdapalene
About AdapaleneNaphthoic acid derivative(a synthetic retinoid like compound), Anti-acne (Acne vulgaris).Mechanism of Action of AdapaleneAdapalene is a chemically stable retinoid-like compound and is a derivative of naphthoic acid. Adapalene binds to specific retinoic acid nuclear receptors and it normalizes differentiation of follicular epithelial cells resulting in decreased comedones (black and white heads) formation. Adapalene inhibits the chemotactic (directional) and chemo kinetic (random) responses of human polymorphonuclear leucocytes and also inhibits the formation of inflammatory mediators by inhibiting metabolism of arachidonic acid. Adapalene also modulates cellular differentiation, keratinization, and inflammatory processes.Pharmacokinets of AdapaleneAbsorption: Absorption after topical administration is minimalOnset of Action for AdapaleneN/ADuration of Action for AdapaleneN/AHalf Life of AdapaleneN/ASide Effects of Adapalene1.Irritation
2.Scaling
3.Erythema
4.Dryness
5.Stinging
6.Burning
7.Pruritis
8.RednessContra-indications of AdapaleneHypersensitivity to AdapaleneSpecial Precautions while taking Adapalene1. Eczema
2. Sun burn
3.Avoid contact with eyes, mucous membrane ,lips, nose, wounds, abrasions, scaly skins
4.Avoid exposure to sunlight and ultraviolet light
5.Use a sunscreen and protective clothing if sun exposure is unavoidable
6.Avoid preparations containing sulphur, Resorcinol, or salicylic acid
7.Avoid occlusive dressingPregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with caution
Below12 years: contraindicated
NEONATES: contraindicatedIndications for AdapaleneAcne vulgarisInteractions for AdapaleneTopical products with a potential for irritation (medicated or abrasive soaps, and cleansers, soaps and cosmetics that have a strong drying effect, and products with high concentrations of alcohol, astringents, spices, or lime), particularly preparations containing sulphur, resorcinol, or salicylic acid in combination with adapalene: Exercise caution with concomitant use of adapalene.
Typical Dosage for AdapaleneAdapalene 0.1% gel is used. Clean and dry the affected area and apply the medicament once daily (at night) for 3 months for acne and 1-4 weeks for psoriasisSchedule of AdapaleneHStorage Requirements for AdapaleneStore at room temperature away from moisture and heat. Keep out of the reach of childrenEffects of Missed Dosage of AdapaleneApply the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of AdapaleneGive supportive measures and symptomatic treatment.Clindamycin Topical
About Clindamycin TopicalMacrolide, Lincosamide Antibiotic (Topical).Mechanism of Action of Clindamycin TopicalIt binds to the 50S sub unit of bacterial ribosome and inhibits translocation.ie:they interfere with the transfer of the newly formed peptide chain from the A site to the P site and fails to expose the A site .So that A site is unable to bind with the next aminoacyl t RNA complex. This leads to premature termination of amino acid chain and there by inhibits protein synthesis.Pharmacokinets of Clindamycin TopicalAbsorption: It is minimally absorbed after topical application.Onset of Action for Clindamycin TopicalN/ADuration of Action for Clindamycin TopicalN/AHalf Life of Clindamycin TopicalN/ASide Effects of Clindamycin Topical1.Burning
2.Stinging
3.Dryness
4.Redness
5.Oiliness
6.Itching
7.Mild irritation
Contra-indications of Clindamycin Topical1.Hypersensitive to Clindamycin
Special Precautions while taking Clindamycin Topical1. Avoid contact with eyes, nose, mouth, and lips and if medication gets in any of these areas, wash with water
2.Avoid use of medicament to broken or irritated skin
3. Avoid using other topical products on the same area at the same
4.History of enteritis, ulcerative colitis, or antibiotic-associated colitis
Pregnancy Related InformationUse with caution.Old Age Related InformationMay be usedBreast Feeding Related InformationUse with caution.Children Related InformationUse with caution.Indications for Clindamycin Topical1.Acne vulgarisInteractions for Clindamycin TopicalN/ATypical Dosage for Clindamycin TopicalApply once daily to washed and dried areas for maximum of 15 minutes initially and increase the exposure graduallySchedule of Clindamycin TopicalN/AStorage Requirements for Clindamycin TopicalThe drug should be store at room temperature.Keep out of reach of children.Effects of Missed Dosage of Clindamycin TopicalApply the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Clindamycin TopicalGive supportive measures and symptomatic treatment.Home Delivery for Adapalene + Clindamycin Topical in Your City
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Adapalene + Clindamycin Topical is a generic medicine name and there are several brands available for it. Some of the brands for adapalene + clindamycin topical might be better known than adapalene + clindamycin topical itself. If the pharmacy that's willing to deliver medicines to your home doesn't have adapalene + clindamycin topical in stock, you can ask for one of the branded alternatives for adapalene + clindamycin topical.