Tretinoin Pharmacology

Tretinoin

About Tretinoin

Retinoid, vitamin A metabolite, Anti-acne,in hyperpigmentation.

Mechanism of Action of Tretinoin

Tretinoin is All Trans retinoic acid (acid form of vitamin A). Tretinoin is a potent comedolytic. It stimulates mitosis and epidermal cell turnover and also promotes lysis of keratocytes. It inhibits the binding of horny cells to each other and prevents the formation of comedones. It acts as a follicular epithelium irritant. Through these actions, the comedo contents are extruded and the formation of the microcomedo, the precursor lesion of acne vulgaris, is reduced

Pharmacokinets of Tretinoin

Absorption: Absorption after topical application is minimal.

Onset of Action for Tretinoin

N/A

Duration of Action for Tretinoin

N/A

Half Life of Tretinoin

N/A

Side Effects of Tretinoin

1. Feeling of warmth
2. Stinging
3. Erythema
4. Peeling
5. Blisters
6. Crusting
7. Pigmentation (hypo/hyper)
8. Contact dermatitis
9. Itching
10. Rredness
11. Edema

Contra-indications of Tretinoin

1. Hypersensitivity to Tretinoin and other Retinoid
2. Abraded skin
3. Sunburn

Special Precautions while taking Tretinoin

1. Eczema
2. Avoid contact with eyes, nose, mucous membrane, open wounds
3. Avoid use of medicated cosmetics and topical preparations containing high level of alcohols, spices or lime
4. Minimize exposure to sunlight and ultraviolet light
5. Avoid concomitant use of keratolytic agents

Pregnancy Related Information

Contraindicated

Old Age Related Information

Use with caution

Breast Feeding Related Information

Use with caution

Children Related Information

Use with caution
NEONATES : Use with caution

Indications for Tretinoin

1. Acne
2. Wrinkles
3. Photo ageing of skin
4. Dry scaly surface

Interactions for Tretinoin

Sulfer, Resorcinol, Benzoyl peroxide or Salicylic acid : Concomitant use of topical keratolytic medications may result in significant skin irritation. Use medicated or abrasive soaps and cleansers, soaps and cosmetics that have a strong drying effect and products with high concentration of alcohol, astringents, spices or lime cautiously because of possible interaction with tretinion.

Typical Dosage for Tretinoin

Topical:
Acne: 0.01-0.1% cream/gel/solution on the affected area 1-2 times daily.
Wrinkling: 0.05% cream is applied once daily at night.

Schedule of Tretinoin

Storage Requirements for Tretinoin

Store at 15 - 25 degree C in a tightly closed container.

Effects of Missed Dosage of Tretinoin

Apply the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.

Effects of Overdose of Tretinoin

Give supportive measures and symptomatic treatment.

Home Delivery for Tretinoin in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including tretinoin.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for tretinoin and other medicines and health products. Home delivery services for tretinoin may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take tretinoin only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for tretinoin before they complete the sale. You can get this information while placing the order for tretinoin with the pharmacy.

Tretinoin is a generic medicine name and there are several brands available for it. Some of the brands for tretinoin might be better known than tretinoin itself. If the pharmacy that's willing to deliver medicines to your home doesn't have tretinoin in stock, you can ask for one of the branded alternatives for tretinoin.