Azelaic Acid Pharmacology
Azelaic Acid
By reducing the concentration of bacteria present on the skin, Azelaic acid decreases the inflammation associated0 with acne lesions. Azelaic acid also possesses a direct anti-inflammatory effect by scavenging oxygen radicals. The anti-keratinizing effects of Azelaic acid may be due to decreased synthesis of filaggrin (keratin filament aggregating protein). By inhibiting filaggrin, Azelaic acid normalizes the keratinization of the follicle and produces a reduction in non-inflamed acne lesions. Azelaic acid does not affect sebum excretion
The antiproliferative and cytotoxic actions of Azelaic acid may be due to reversible inhibition of a variety of oxido-reductive enzymes including DNA polymerase, tyrosinase, and mitochondrial enzymes of the respiratory chain. At the cellular level, Azelaic acid causes mitochondrial swelling and accumulation of cytoplasmic lipid droplets. Azelaic acid has shown efficacy in treating lentigo, cutaneous malignant melanoma, and melasma (chloasma). When Azelaic acid is applied topically in these conditions, there is a reduction in epidermal melanogenesis and replacement of abnormal melanocytes by normal cells; flattening of nodular areas may also occur. Hyperactive and malignant melanocytes are much more susceptible to the effects of Azelaic acid than are normal melanocytes.
2.Burning
3.Pruritis
4.Stinging
5.Tingling
6.Itching
7.Redness
8.Dryness
9.Peeling
10.Warmth
2.Stop the use of medicament if irritation occurs
3.Avoid use of Azelaic acid topical on dry chapped or irritated skin wounds or in Eczema
4.Avoid occlusive dressing
NEONATES: contraindicated
2.Lentigo
3.Cutaneous malignant melanoma
4.Melasma (chloasma)
Home Delivery for Azelaic Acid in Your City
Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including azelaic acid.
However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for azelaic acid and other medicines and health products. Home delivery services for azelaic acid may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
Please be aware that you should take azelaic acid only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for azelaic acid before they complete the sale. You can get this information while placing the order for azelaic acid with the pharmacy.
Azelaic Acid is a generic medicine name and there are several brands available for it. Some of the brands for azelaic acid might be better known than azelaic acid itself. If the pharmacy that's willing to deliver medicines to your home doesn't have azelaic acid in stock, you can ask for one of the branded alternatives for azelaic acid.