Tenoxicam Pharmacology

Tenoxicam

About Tenoxicam
N/A
Mechanism of Action of Tenoxicam
The anti-inflammatory effects of Tenoxicam may result from the inhibition of the enzyme cyclooxygenase and the subsequent peripheral inhibition of prostaglandin synthesis (prostaglandins sensitize pain receptors, their inhibition accounts for the peripheral analgesic effects of tenoxicam). Antipyresis may occur due to its central action on the hypothalamus (resulting in peripheral dilation, increased cutaneous blood flow, and subsequent heat loss).Drug inhibits platelet aggregation (prolongs bleeding time) .It act as a scavenger for active oxygen at the site of inflammation. It also inhibits human metalloproteinases (stromelysin and collagenase) which induce cartilage breakdown.
Pharmacokinets of Tenoxicam
Absorption- Rapidly and completely absorbed after oral administration.
Distribution- It is widely distributed in the body as plasma protein bound form. In the blood over 99% of the medicine is bound to albumin. It enters to the synovial fluid.
Metabolism- Completely metabolized into inactive metabolites. 5`-hydroxy-tenoxicam is its main metabolite.
Excretion- Excreted through urine and faeces.
Onset of Action for Tenoxicam
1-2 hrs
Duration of Action for Tenoxicam
24 hrs
Half Life of Tenoxicam
72 hours (range 59 to 74 hours)
Side Effects of Tenoxicam
1. Nausea
2. Vomiting
3. Epigastric distress
4. Dyspepsia
5. Skin rash
6. Headache
7. Oedema
8. Visual disturbances
9. Blood dyscrasias
10. Constipation
11. Diarrhoea
12. Stomatitis
13. Gastric Ulcers
14. GI-bleeding including haematemesis and melena
15. Sleep disturbances
16. Appetite loss
17. Vertigo
18. Increased liver enzyme activity
19. Stevens-Johnson syndrome
20. Photosensitivity reaction
21. Vasculitis
22. Anemia
23. Agranulocytosis
24. Leucopenia
25. Thrombocytopenia

Contra-indications of Tenoxicam
1. Hypersensitivity to the drug
2. Other NSAIDs induced allergy
3. Active peptic ulcer
4. History of recurrent ulcer
5. GI bleeding
6. Gastritis
Special Precautions while taking Tenoxicam
1. Impairment of hepatic function
2. Renal dysfunction
3. Cardiac failure
Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated
Children Related Information
Use with caution
Indications for Tenoxicam
1. Rheumatoid arthritis
2. Osteoarthritis
3. Short-term treatment of soft tissue injuries
4. Arthrosis
5. Ankylosing spondylitis
6. Tendinitis
7. Bursitis
8. Periarthritis of shoulders (shoulder-hand syndrome) or hips
9. Strains and sprains
10. Post-operative pain
11. Acute gout
12. Primary dysmenorrhea
Interactions for Tenoxicam
N/A
Typical Dosage for Tenoxicam
Oral-
Adults- 20 mg daily.
Schedule of Tenoxicam
N/A
Storage Requirements for Tenoxicam
Store below 30 degree C. Protect from light and moisture.
Effects of Missed Dosage of Tenoxicam
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Tenoxicam
Give symptomatic and supportive treatment. Induce gastric emesis and administer activated charcoal to reduce further adsorption of drugs.

Home Delivery for Tenoxicam in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including tenoxicam.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for tenoxicam and other medicines and health products. Home delivery services for tenoxicam may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take tenoxicam only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for tenoxicam before they complete the sale. You can get this information while placing the order for tenoxicam with the pharmacy.

Tenoxicam is a generic medicine name and there are several brands available for it. Some of the brands for tenoxicam might be better known than tenoxicam itself. If the pharmacy that's willing to deliver medicines to your home doesn't have tenoxicam in stock, you can ask for one of the branded alternatives for tenoxicam.