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- Pharmacology For Fluocinolone acetonide + Salicylic acid + Benzoic acid
Fluocinolone acetonide + Salicylic acid + Benzoic acid Pharmacology
Fluocinolone acetonide + Salicylic acid + Benzoic acid
About Fluocinolone acetonide + Salicylic acid + Benzoic acidN/AMechanism of Action of Fluocinolone acetonide + Salicylic acid + Benzoic acidN/APharmacokinets of Fluocinolone acetonide + Salicylic acid + Benzoic acidN/AOnset of Action for Fluocinolone acetonide + Salicylic acid + Benzoic acidN/ADuration of Action for Fluocinolone acetonide + Salicylic acid + Benzoic acidN/AHalf Life of Fluocinolone acetonide + Salicylic acid + Benzoic acidN/ASide Effects of Fluocinolone acetonide + Salicylic acid + Benzoic acidN/AContra-indications of Fluocinolone acetonide + Salicylic acid + Benzoic acidN/ASpecial Precautions while taking Fluocinolone acetonide + Salicylic acid + Benzoic acidN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Fluocinolone acetonide + Salicylic acid + Benzoic acidN/AInteractions for Fluocinolone acetonide + Salicylic acid + Benzoic acidN/ATypical Dosage for Fluocinolone acetonide + Salicylic acid + Benzoic acidN/ASchedule of Fluocinolone acetonide + Salicylic acid + Benzoic acidN/AStorage Requirements for Fluocinolone acetonide + Salicylic acid + Benzoic acidN/AEffects of Missed Dosage of Fluocinolone acetonide + Salicylic acid + Benzoic acidN/AEffects of Overdose of Fluocinolone acetonide + Salicylic acid + Benzoic acidN/AFluocinolone acetonide
About Fluocinolone acetonideA synthetic hydrocortisone derivative, Vasoprotective ,reduce skin inflammation.Mechanism of Action of Fluocinolone acetonideFluocinolone is a topical high potency glucocorticoid.
The drug exerts its pharmacological action by penetrating and binding to cytoplasmic receptor protein and causes a structural change in steroid receptor complex. This structural change allows it`s migration in to the nucleus and then binding to specific sites on the DNA which leads to transcription of specific m-RNA and which ultimately regulates protein synthesis. It exerts highly selective glucocorticoid action. It stimulates the enzymes needed to decrease the inflammatory response.
The drug exerts anti-inflammatory and immunosuppressant actions as follows: - 1) Induce lipocortins in macrophages, endothelium, and fibroblasts which inhibits Phospholipase A2 and thus decreases the production of Prostaglandins, leukotrienes (LT), and platelet activating factor, 2) Causes negative regulation of genes for cytokines in macrophages, endothelial cells and lymphocytes and thus decreases the production of interleukins (IL-1, IL-2, IL-3, IL-6), TNF-?, GM-CSF (granulocyte macrophage colony stimulating factor), Gama interferon and suppresses fibroblast proliferation and T-lymphocyte functions and interferes chemo taxis. 3) Decreases the production of acute phase reactants from macrophages and endothelial cells and interferes complement function. 4) Decreases the production of ELAM-1(Endothelial leukocyte adhesion molecule-1) and ICAM-1(intracellular adhesion molecule-1) in endothelial cells. 5) Inhibit IgE mediated histamine and LT-C4 release from basophiles and the effects of antigen-antibody reaction is not mediated 6) Reduces the production of collagenase and stromolysin and thus prevents tissue destruction.
Fluocinolone also has immunosuppressant and antimitotic actions.
Pharmacokinets of Fluocinolone acetonideAbsorption: Fluocinolone is absorbed( <1 %) through intact skin after topical administration and the amount absorbed is depending on the type of inflammation, vehicle used, area of skin and the epidermal barrier.Onset of Action for Fluocinolone acetonideN/ADuration of Action for Fluocinolone acetonideN/AHalf Life of Fluocinolone acetonideN/ASide Effects of Fluocinolone acetonide1.Thinning of epidermis
2.Burning
3. Itching
4.Irritation
5.Atrophy (Dermal changes)
6.Telangiectasia
7.Striae
8. Hypopigmentation
9.Contact dermatitis
10.Perioral dermatitis
11.Stinging
12.Cataract,Glaucoma, Corneal ulcers caused by application around eyelids and surrounding skin
13. Hypertrichosis
14. Dryness
15. Acne
Contra-indications of Fluocinolone acetonide1. Hypersensitivity to Fluocinolone and other corticosteroids
2.Acne vulgaris
3.Acne Rosacea
4.Nappy rash
5. Tuberculosis infection of the skin
6.Viral, fungal or bacterial primary infections
7.Ulcers
Special Precautions while taking Fluocinolone acetonide1.Avoid application on large surface area
2. Prolonged use
3.Psoriasis
4.Avoid contact with eyes
5. Avoid occlusive dressing
6.Not used more than 5 days on the face or in the children
7. If irritation or hypersensitivity occurs avoid the use of medicaments.
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with caution
NEONATES: contraindicatedIndications for Fluocinolone acetonide1.Psoriasis
2.Eczema
3.Otitis externa
4.Lichen simplex and planus
5.Anal and vulval pruritis
6.Contact dermatitis
7.Seborrheic dermatitis
8. Dermatoses (secondary infected)
Interactions for Fluocinolone acetonideN/ATypical Dosage for Fluocinolone acetonideTopical: Fluocinolone 0.0025 %, 0.01% cream, ointment, gel or lotion is used. Clean and dry the affected area and apply the medicament thinly and evenly on the affected area for 2 - 3 times daily for 2 weeks.Schedule of Fluocinolone acetonideN/AStorage Requirements for Fluocinolone acetonideStore at room temperature. Protect from heat and moisture. Keep out of the reach of childrenEffects of Missed Dosage of Fluocinolone acetonideApply the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Fluocinolone acetonideGive supportive measures and symptomatic treatment.Salicylic Acid
About Salicylic AcidA beta hydroxy acid, Keratolytic, Topical Skin Product(Anti Acne).Mechanism of Action of Salicylic AcidIt is a keratolytic agent. It encourages exfoliation of the skin and opening up of the plugged follicles, which helps re-establish the normal skin- cell replacement cycle. For milder acne, salicylic acid helps unclog pores to resolve and prevent lesions.Pharmacokinets of Salicylic AcidN/AOnset of Action for Salicylic AcidN/ADuration of Action for Salicylic AcidN/AHalf Life of Salicylic AcidN/ASide Effects of Salicylic Acid1.Allergic reaction
2.Hives
3.Difficulty breathing
4.Swelling of your face, lips, tongue, or throat.
Contra-indications of Salicylic Acid1.Hypersensitivity to Salicylic acidSpecial Precautions while taking Salicylic Acid1.Avoid contact with eyes, mouth, or nose.
2.Like many other topical acne treatments, salicylic acid must be used continuously, even after acne lesions have.Pregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Salicylic Acid1.Treats skin irritation and inflammation caused by burns, insect bites, fungal infections, and eczema.Interactions for Salicylic AcidN/ATypical Dosage for Salicylic AcidUse this medication twice daily Schedule of Salicylic AcidN/AStorage Requirements for Salicylic AcidStore in a cool dry place. Protect from heat and light. Keep out of the reach of childrenEffects of Missed Dosage of Salicylic AcidApply the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Salicylic AcidGive supportive measures and symptomatic treatment.Benzoic Acid
About Benzoic AcidAntibacterial. A fungistatic compound,preservatives.Mechanism of Action of Benzoic AcidN/APharmacokinets of Benzoic AcidN/AOnset of Action for Benzoic AcidN/ADuration of Action for Benzoic AcidN/AHalf Life of Benzoic AcidN/ASide Effects of Benzoic Acid1.Allergic reaction
2.Hives
3.Difficulty breathing
4.Swelling of your face, lips, tongue, or throat.
Contra-indications of Benzoic Acid1.Hypersensitivity to Benzoic acidSpecial Precautions while taking Benzoic AcidAvoid contact with eyes, mouth, or nose.Pregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Benzoic Acid1.Treats skin irritation and inflammation caused by burns, insect bites, fungal infections, and eczema.Interactions for Benzoic AcidN/ATypical Dosage for Benzoic AcidUse this medication twice daily Schedule of Benzoic AcidN/AStorage Requirements for Benzoic AcidStore in a cool dry place. Protect from heat and light. Keep out of the reach of childrenEffects of Missed Dosage of Benzoic AcidApply the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Benzoic AcidGive supportive measures and symptomatic treatment.Home Delivery for Fluocinolone acetonide + Salicylic acid + Benzoic acid in Your City
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Fluocinolone acetonide + Salicylic acid + Benzoic acid is a generic medicine name and there are several brands available for it. Some of the brands for fluocinolone acetonide + salicylic acid + benzoic acid might be better known than fluocinolone acetonide + salicylic acid + benzoic acid itself. If the pharmacy that's willing to deliver medicines to your home doesn't have fluocinolone acetonide + salicylic acid + benzoic acid in stock, you can ask for one of the branded alternatives for fluocinolone acetonide + salicylic acid + benzoic acid.