Hydrocortisone Topical + Miconazole Pharmacology
Hydrocortisone Topical + Miconazole
Hydrocortisone Topical
The drug exerts anti-inflammatory and immunosuppressant actions as follows: - 1) Induce lipocortins in macrophages, endothelium, and fibroblasts which inhibits phospholipase A2 and thus decreases the production of Prostaglandins, leukotriens (LT), and platelet activating factor, 2) Causes negative regulation of genes for cytokines in macrophages, endothelial cells and lymphocytes and thus decreases the production of interleukins (IL-1, IL-2, IL-3, IL-6), TNF-alpha, GM-CSF (granulocyte macrophage colony stimulating factor), Gama interferon and suppresses fibroblast proliferation and T-lymphocyte functions and interferes chemo taxis. 3) Decreases the production of acute phase reactants from macrophages and endothelial cells and interferes complement function. 4) Decreases the production of ELAM-1(Endothelial leukocyte adhesion molecule-1) and ICAM-1(intracellular adhesion molecule-1) in endothelial cells. 5) Inhibit IgE mediated histamine and LT-C4 release from basophiles and the effects of antigen-antibody reaction is not mediated 6) Reduces the production of collagenase and stromolysin and thus prevents tissue destruction.
Distribution: Distributed throughout the local skin layers. Any drug absorbed in to circulation is rapidly removed from blood and distributed in to muscle, liver, kidney, skin, and intestine.
Metabolism: Metabolized primarily in skin and a small amount absorbed is metabolized in liver.
Excretion: Metabolites are excreted mainly through urine and a small amount is excreted through faeces.
2. Irritation
3. Pruritus
4. Dryness
5. Erythema
6. Folliculitis
7. Hypertrichosis
8. Acneiform eruptions
9. Allergic contact dermatitis
10. Secondary infections
11. Atrophy
12. Striae
2. Local or systemic infections
3. Fungal or herpetic keratitis
4. Cataract
5. Tubercular or syphilitic lesions
2. Use of potent preparations should be short term or intermittent
3. Milder drugs should be used in acute lesions and stronger ones are for chronic lesions
4. Avoid sudden discontinuation of the drug.
NEONATES : Contraindicated
2. Inflammations of corticosteroid-responsive dermatoses
3. Seborrheic dermatitis of scalp
Oral contraceptives: Increase concentration of hydrocortisone.
Oestrogens: Decreases clearance of hydrocortisone.
Ketoconazole: Decreases clearance of hydrocortisone.
Rifampicin: Decreases efficacy.
Hydrocortisone effects the actions of the following:
Anticholinesterases: Efficacy antagonised in myasthenia gravis.
Oral anticoagulants: Altered response.
Cyclosporine: Increases efficacy, enhanced toxicity may occur.
Digitalis glycosides: May enhance toxicity.
Isoniazid: Decreases serum levels.
Salicylates: Decreases serum levels.
Diuretics (K sparing): May cause hypokalaemia.
Non-depolarising muscle relaxants: Altered response of either agent may occur.
Somatrem: Growth promoting effect inhibited.
Theophyllines: Altered response of either agent.
Lab. Tests: Increases serum cholesterol levels. Increases urine glucose levels. Decreases Thyroid I131 uptake; Decreases T3 serum levels. Decreases serum potassium.
Apply 0.1% to 2.5% 1 to 4 times daily.
Ointment:
0.5% to 2.5% Apply 1 to 4 times as required
Lotion:
0.25% to 2.5% Apply 1 to 4 times as required
Gel:
0.5% to 1% Apply 1 to 4 times as required
Aerosol:
Seborrheic dermatitis of scalp:
0.5% to 1%Apply for only 3seconds. Directly spray in to the affected area from 15 cm apart. No need for massage or rub. Apply 1 to 4 times daily until acute phase is controlled. Then reduce the dosage to 0nce to thrice weekly.
Miconazole
2.Burning
3.Irritation
4.Pruritis
5.Maceration
6.Dermatitis
NEONATES: contraindicated
2.Vulvovaginal candidiasis
3.Tinea pedis
4.Tinea corporis
5.Tinea cruris
6.Otomycosis
7.Onychomycosis
8.Oral candidiasis
9.Intestinal candidiasis
10.Diaper dermatitis
Cutaneous infections: Apply the cream twice daily on the affected part for about 1 month
Tinea versicolor: Apply the cream once daily on the affected part
Vaginal use: Insert 300 mg suppository at bed time for 3 days or Insert 100 mg suppository at bed time for 7 days
CHILDREN:
Topical use:
Cutaneous infections: Apply the cream twice daily on the affected part for about 1 month
Tinea vericolor: Apply the cream once daily on the affected part
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Hydrocortisone Topical + Miconazole is a generic medicine name and there are several brands available for it. Some of the brands for hydrocortisone topical + miconazole might be better known than hydrocortisone topical + miconazole itself. If the pharmacy that's willing to deliver medicines to your home doesn't have hydrocortisone topical + miconazole in stock, you can ask for one of the branded alternatives for hydrocortisone topical + miconazole.