Halobetasol propionate Pharmacology

Halobetasol propionate

About Halobetasol propionate
Topical primarily synthetic Corticosteroid, Antiinflammatory and antipruritic.
Mechanism of Action of Halobetasol propionate
Halobetasol propionate is a synthetic corticosteroid for topical dermatological use. The drug exerts its pharmacological action by penetrating and binding to cytoplasmic receptor protein and causes a structural change in steroid receptor complex. This structural change allows its migration in to the nucleus and then binding to specific sites on the DNA which leads to transcription of specific m-RNA and which ultimately regulates protein synthesis. It exerts highly selective glucocorticoid action. It stimulates the enzymes needed to decrease the inflammatory response.
The drug exerts anti-inflammatory and immunosuppressant actions as follows: - 1) Induce lipocortins in macrophages, endothelium, and fibroblasts which inhibits phospholipase A2 and thus decreases the production of Prostaglandins, leukotriens (LT), and platelet activating factor, 2) Causes negative regulation of genes for cytokines in macrophages, endothelial cells and lymphocytes and thus decreases the production of interleukins (IL-1, IL-2, IL-3, IL-6), TNF-alpha, GM-CSF (granulocyte macrophage colony stimulating factor), Gama interferon and suppresses fibroblast proliferation and T-lymphocyte functions and interferes chemotaxis. 3) Decreases the production of acute phase reactants from macrophages and endothelial cells and interferes complement function. 4) Decreases the production of ELAM-1(Endothelial leukocyte adhesion molecule-1) and ICAM-1(intracellular adhesion molecule-1) in endothelial cells. 5) Inhibit IgE mediated histamine and LT-C4 release from basophiles and the effects of antigen-antibody reaction is not mediated 6) Reduces the production of collagenase and stromolysin and thus prevents tissue destruction.
Pharmacokinets of Halobetasol propionate
Absorption: It is absorbed after topical application.
Onset of Action for Halobetasol propionate
N/A
Duration of Action for Halobetasol propionate
N/A
Half Life of Halobetasol propionate
N/A
Side Effects of Halobetasol propionate
1.Burning
2.Stinging
3.Itching
4.Redness
5.Blistering
6.Peeling
Contra-indications of Halobetasol propionate
1.Hypersensitivity to Halobetasol propionate
2.Occlusive dressings
Special Precautions while taking Halobetasol propionate
1.Avoid contact with eyes
2.For external use only
3.Prolonged use
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution
NEONATES: contraindicated
Indications for Halobetasol propionate
1.Eczema
2.Psoriasis
3.Dermatitis
4. Rashes
5.Insect bites
6.Poison ivy
7.Inflammation of the skin
Interactions for Halobetasol propionate
N/A
Typical Dosage for Halobetasol propionate
Apply to the affected area 2 - 4 times a day. Halobetasol should not be used for longer than 2 weeks
Schedule of Halobetasol propionate
N/A
Storage Requirements for Halobetasol propionate
Store at room temperature in a well closed; light resistant container. Protect from excess heat and moisture. Keep out of reach of children.
Effects of Missed Dosage of Halobetasol propionate
Apply the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Halobetasol propionate
Provide symptomatic treatment and supportive measures.

Home Delivery for Halobetasol propionate in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including halobetasol propionate.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for halobetasol propionate and other medicines and health products. Home delivery services for halobetasol propionate may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take halobetasol propionate only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for halobetasol propionate before they complete the sale. You can get this information while placing the order for halobetasol propionate with the pharmacy.

Halobetasol propionate is a generic medicine name and there are several brands available for it. Some of the brands for halobetasol propionate might be better known than halobetasol propionate itself. If the pharmacy that's willing to deliver medicines to your home doesn't have halobetasol propionate in stock, you can ask for one of the branded alternatives for halobetasol propionate.