Halcinonide Pharmacology
Halcinonide
The drug exerts its pharmacological action by penetrating and binding to cytoplasmic receptor protein and causes a structural change in steroid receptor complex. This structural change allows it`s migration in to the nucleus and then binding to specific sites on the DNA which leads to transcription of specific m-RNA and which ultimately regulates protein synthesis. It exerts highly selective glucocorticoid action. It stimulates the enzymes needed to decrease the inflammatory response.
The drug exerts anti-inflammatory and immunosuppressant actions as follows: - 1) Induce lipocortins in macrophages, endothelium, and fibroblasts which inhibits Phospholipase A2 and thus decreases the production of Prostaglandins, leukotrienes (LT), and platelet activating factor, 2) Causes negative regulation of genes for cytokines in macrophages, endothelial cells and lymphocytes and thus decreases the production of interleukins (IL-1, IL-2, IL-3, IL-6), TNF-alpha, GM-CSF (granulocyte macrophage colony stimulating factor), Gama interferon and suppresses fibroblast proliferation and T-lymphocyte functions and interferes chemo taxis. 3) Decreases the production of acute phase reactants from macrophages and endothelial cells and interferes complement function. 4) Decreases the production of ELAM-1(Endothelial leukocyte adhesion molecule-1) and ICAM-1(intracellular adhesion molecule-1) in endothelial cells. 5) Inhibit IgE mediated histamine and LT-C4 release from basophiles and the effects of antigen-antibody reaction is not mediated 6) Reduces the production of collagenase and stromolysin and thus prevents tissue destruction.
2.Burning
3.Itching
4.Irritation
5.Atrophy (Dermal changes)
6.Telangiectasia
7.Striae
8.Hypopigmentation
9.Contact dermatitis
10.Perioral dermatitis
11.Papular disorder
12.Cataract, Glaucoma, Corneal ulcers caused by application around eyelids and surrounding skin
2.Acne vulgaris
3.Acne Rosacea
4.Nappy rash
5.Tuberculosis infection of the skin
6.Viral, fungal or bacterial primary infections
7.Ulcers
2.Prolonged use
3.Psoriasis
4.Avoid contact with eyes
5.Avoid occlusive dressing
6.Not used more than 5 days on the face or in the children
NEONATES: contraindicated
1.Impetigo
2.Furunculosis
3.Dermatoses (secondary infected)
4.Eczema
Home Delivery for Halcinonide in Your City
Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including halcinonide.
However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for halcinonide and other medicines and health products. Home delivery services for halcinonide may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
Please be aware that you should take halcinonide only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for halcinonide before they complete the sale. You can get this information while placing the order for halcinonide with the pharmacy.
Halcinonide is a generic medicine name and there are several brands available for it. Some of the brands for halcinonide might be better known than halcinonide itself. If the pharmacy that's willing to deliver medicines to your home doesn't have halcinonide in stock, you can ask for one of the branded alternatives for halcinonide.