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- Pharmacology For Miconazole + Triamcinolone acetonide
Miconazole + Triamcinolone acetonide Pharmacology
Miconazole + Triamcinolone acetonide
About Miconazole + Triamcinolone acetonideN/AMechanism of Action of Miconazole + Triamcinolone acetonideN/APharmacokinets of Miconazole + Triamcinolone acetonideN/AOnset of Action for Miconazole + Triamcinolone acetonideN/ADuration of Action for Miconazole + Triamcinolone acetonideN/AHalf Life of Miconazole + Triamcinolone acetonideN/ASide Effects of Miconazole + Triamcinolone acetonideN/AContra-indications of Miconazole + Triamcinolone acetonideN/ASpecial Precautions while taking Miconazole + Triamcinolone acetonideN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Miconazole + Triamcinolone acetonideN/AInteractions for Miconazole + Triamcinolone acetonideN/ATypical Dosage for Miconazole + Triamcinolone acetonideN/ASchedule of Miconazole + Triamcinolone acetonideN/AStorage Requirements for Miconazole + Triamcinolone acetonideN/AEffects of Missed Dosage of Miconazole + Triamcinolone acetonideN/AEffects of Overdose of Miconazole + Triamcinolone acetonideN/AMiconazole
About MiconazoleAn imidazole derivative, Broad spectrum Antifungal.Mechanism of Action of MiconazoleMiconazole is fungicidal or fungistatic depending on the drug concentrations. I t inhibits the conversion of Lanosterol to 14 demethyl Lanosterol by inhibiting the cytochromeP450 enzyme 14 alpha demethylase and impair ergosterol synthesisPharmacokinets of MiconazoleAbsorption: Oral absorption of Miconazole is poor. Distribution: It is distributed in the body in protein bound form Metabolism: It undergoes metabolism in the liver. Excretion: It is excreted in urine and faeces.Onset of Action for MiconazoleN/ADuration of Action for MiconazoleN/AHalf Life of Miconazole1 daySide Effects of Miconazole1.Vulvovaginal burning
2.Burning
3.Irritation
4.Pruritis
5.Maceration
6.Dermatitis Contra-indications of Miconazole1.Hypersensitivity to Miconazole and other Azole antifungalsSpecial Precautions while taking Miconazole1.Hepatic dysfunctionPregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationUse with caution
NEONATES: contraindicated
Indications for Miconazole1.Tinea versicolor
2.Vulvovaginal candidiasis
3.Tinea pedis
4.Tinea corporis
5.Tinea cruris
6.Otomycosis
7.Onychomycosis
8.Oral candidiasis
9.Intestinal candidiasis
10.Diaper dermatitisInteractions for MiconazoleBenzoyl peroxide: Antibacterial synergism. Typical Dosage for MiconazoleAdult: Topical use:
Cutaneous infections: Apply the cream twice daily on the affected part for about 1 month
Tinea versicolor: Apply the cream once daily on the affected part
Vaginal use: Insert 300 mg suppository at bed time for 3 days or Insert 100 mg suppository at bed time for 7 days
CHILDREN:
Topical use:
Cutaneous infections: Apply the cream twice daily on the affected part for about 1 month
Tinea vericolor: Apply the cream once daily on the affected part
Schedule of MiconazoleHStorage Requirements for MiconazoleThe drug should be stored at 15 - 30 degree C.Effects of Missed Dosage of MiconazoleTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of MiconazoleGive supportive measures and treatment.
Triamcinolone acetonide
About Triamcinolone acetonideA synthetic glucocorticoid, Topical anti-inflammatory(steroidal).Mechanism of Action of Triamcinolone acetonideThe drug exerts it`s pharmacological action by penetrating and binding to cytoplasmic receptor protein and causes a structural change in steroid receptor complex. This structural change allows it`s migration in to the nucleus and then binding to specific sites on the DNA which leads to transcription of specific m-RNA and which ultimately regulates protein synthesis. It exerts more selective glucocorticoid action. It stimulates the enzymes needed to decrease the inflammatory response.
The drug exerts anti-inflammatory and immunosuppressant actions as follows: - 1) Induce lipocortins in macrophages, endothelium, and fibroblasts which inhibits phospholipase A2 and thus decreases the production of Prostaglandins, leukotriens (LT), and platelet activating factor, 2) Causes negative regulation of genes for cytokines in macrophages, endothelial cells and lymphocytes and thus decreases the production of interleukins (IL-1, IL-2, IL-3, IL-6), TNF-a, GM-CSF (granulocyte macrophage colony stimulating factor), Gama interferon and suppresses fibroblast proliferation and T-lymphocyte functions and interferes chemo taxis. 3) Decreases the production of acute phase reactants from macrophages and endothelial cells and interferes complement function. 4) Decreases the production of ELAM-1(Endothelial leukocyte adhesion molecule-1) and ICAM-1(intracellular adhesion molecule-1) in endothelial cells. 5) Inhibit IgE mediated histamine and LT-C4 release from basophiles and the effects of antigen-antibody reaction is not mediated 6) Reduces the production of collagenase and stromolysin and thus prevents tissue destruction.
Pharmacokinets of Triamcinolone acetonideAbsorption: Triamcinolone acetonide is absorbed after topical application. Distribution: It is distributed mainly in protein bound form. Metabolism: It is metabolized primarily in the liver. Excretion: It is excreted by the kidneys and small amount is excreted through bile also.Onset of Action for Triamcinolone acetonideN/ADuration of Action for Triamcinolone acetonideN/AHalf Life of Triamcinolone acetonideN/ASide Effects of Triamcinolone acetonide1.Burning
2.Itching
3.Irritation
4.Dryness
5.Folliculitis
6.Hypertrichosis
7.Acneiform eruptions
8.Hypopigmentation
9.Dermatitis
10.Secondary infection
11.Skin atrophy
Contra-indications of Triamcinolone acetonideHypersensitivity to Triamcinolone acetonideSpecial Precautions while taking Triamcinolone acetonide1.Occlusive dressingsPregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with cautionIndications for Triamcinolone acetonide1. Inflammations of corticosteroid-responsive dermatoses
2. Treatment of skin disorders: Dermatitis, Psoriasis
Interactions for Triamcinolone acetonideN/ATypical Dosage for Triamcinolone acetonideTopical application: Apply the cream on the affected area 2-4 times daily; depending on the severity of the condition. Schedule of Triamcinolone acetonideN/AStorage Requirements for Triamcinolone acetonideStore at room temperature at a range of 15 to 30 degree C. Protect from light and moisture. Keep out of reach of children.Effects of Missed Dosage of Triamcinolone acetonideApply the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Triamcinolone acetonideProvide symptomatic treatment and supportive measures.Home Delivery for Miconazole + Triamcinolone acetonide in Your City
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