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- Pharmacology For Terbinafine + Fluticasone
Terbinafine + Fluticasone Pharmacology
Terbinafine + Fluticasone
About Terbinafine + FluticasoneN/AMechanism of Action of Terbinafine + FluticasoneN/APharmacokinets of Terbinafine + FluticasoneN/AOnset of Action for Terbinafine + FluticasoneN/ADuration of Action for Terbinafine + FluticasoneN/AHalf Life of Terbinafine + FluticasoneN/ASide Effects of Terbinafine + FluticasoneN/AContra-indications of Terbinafine + FluticasoneN/ASpecial Precautions while taking Terbinafine + FluticasoneN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Terbinafine + FluticasoneN/AInteractions for Terbinafine + FluticasoneN/ATypical Dosage for Terbinafine + FluticasoneN/ASchedule of Terbinafine + FluticasoneN/AStorage Requirements for Terbinafine + FluticasoneN/AEffects of Missed Dosage of Terbinafine + FluticasoneN/AEffects of Overdose of Terbinafine + FluticasoneN/ATerbinafine
About TerbinafineA synthetic allylamine derivative, Antifungal.Mechanism of Action of TerbinafineTerbinafine is a fungicidal drug. It interfere the conversion of Squalene to Ergosterol by inhibiting the enzyme Squalene epoxidase.This results in accumulation of Squalene in the fungal cells and leads to membrane distortion and death of the Fungus.Pharmacokinets of TerbinafineAbsorption: It is well absorbed after oral administration.
Distribution: It is distributed in the body in protein bound form. It is concentrated in nail, skin and sebum.
Metabolism: It is metabolised to inactive metabolite in the liver.
Excretion: It is excreted mainly through urine
Onset of Action for Terbinafine2 weeksDuration of Action for TerbinafineN/AHalf Life of Terbinafine17 hourSide Effects of Terbinafine1. Nausea
2. Vomiting
3. Diarrhoea
4. Gastric upset
5. Taste disturbances
6. Visual disturbances
7. Headache
8. Neutropenia
9. Erythema
10. Itching
11. Urticaria
12. Rash
Contra-indications of Terbinafine1. Hypersensitivity to TerbinafineSpecial Precautions while taking Terbinafine1. Renal Impairment
2. Hepatic dysfunction
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationBelow 12 : ContraindicatedIndications for Terbinafine1. Tinea pedis
2. Tinea corporis
3. Tinea capitis
4. Tinea cruris
5. Onychomycosis
Interactions for TerbinafineCimetidine: Terbinafine clearance is decreased 33%.
Rifampicin: Terbinafine clearance is increased 100%.
Terfenadine: Terbinafine clearance is decreased 16%.
Cyclosprorin: Clearance of cyclospronine increased by 15%.Typical Dosage for TerbinafineAdult & Children above age 12: 250 mg daily
Finger nails: 250 mg /day for 11/2 month
Toe nails: 250 mg /day for 3 month
Schedule of TerbinafineHStorage Requirements for TerbinafineThe drug should be kept at 30 degree C.Keep away from moisture and light.Effects of Missed Dosage of TerbinafineTake the missed dose as soon as noticed and if it is the time to take the next dose then skip the missed dose and continue the regular schedule.Effects of Overdose of TerbinafineGive supportive measures and treatment.Fluticasone
About FluticasoneSynthetic topical glucocorticoid, Anti inflammatory and antipruritic in corticosteroid-responsive dermatoses; atopic dermatitis.Mechanism of Action of FluticasoneIt reduces prostaglandin synthesis by inhibiting cyclo oxygenase enzymes both COX1 and COX2.In higher doses it reduces the thromboxane A2 synthesis by COX1 inhibition. So platelet aggregation is inhibited by this drug. After topical application in the case of ophthalmic preparation it prevents miosis by reducing ocular prostaglandins synthesis. It is a phenylalkalonic acid derivative Non Steroidal Anti Inflammatory Drug.
Pharmacokinets of FluticasoneAbsorption- Well absorbed orally.
Distribution-99% bound to the plasma proteins.
Metabolism- In liver it is metabolized by hydroxylation and conjugation.
Excretion-It is excreted through urine.
Onset of Action for Fluticasone30-60minDuration of Action for Fluticasone8-12hrsHalf Life of Fluticasone6-10 hrsSide Effects of Fluticasone1. Anxiety
2. Insomnia
3. Tremors
4. Depression
5. Heart failure
6. Visual changes
7. Renal failure
8. Thrombocytopenia
9. Aplastic anemia
10. Photosensitivity
11. Urticaria
12. Angioedema
Contra-indications of Fluticasone1. Hypersensitivity to this drug
2. Peptic ulcer
3. Gastro intestinal bleeding
4. Bronchospasm
5. Hypersensitivity
6. Herpes simplex keratitis
Special Precautions while taking Fluticasone1. Renal failure
2. Hyper tension
3. Hypersensitive to other Non Steroidal Anti Inflammatory Drugs
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with caution.
NEONATES: contraindicatedIndications for Fluticasone1. Rheumatoid arthritis
2. Osteo arthritis
3. Ankylosing spondylitis
4. Pain in patients with dysmenorrhea.
5. Post operative inflammation of the eye.
6. Migraine
7. Acute gout
Interactions for FluticasoneNone reported.
Typical Dosage for FluticasoneOral
Adults- 200-300mg/day in 2-4 divided doses.
Topicaly-0.03% ophthalmic solution. Add 1 drop in every ? hr to the eyes beginning 2-3 hrs before surgery.
Schedule of FluticasoneHStorage Requirements for FluticasoneStore in a sealed container at room a temperature and avoid moisture.
In the case of ophthalmic preparation stored between 15 and 30 degree Celsius.
Effects of Missed Dosage of FluticasoneTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of FluticasoneSupportive and symptomatic treatment should be given. Empty the stomach by emesis or gastric lavage. Home Delivery for Terbinafine + Fluticasone in Your City
Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including terbinafine + fluticasone.
However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for terbinafine + fluticasone and other medicines and health products. Home delivery services for terbinafine + fluticasone may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
Please be aware that you should take terbinafine + fluticasone only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for terbinafine + fluticasone before they complete the sale. You can get this information while placing the order for terbinafine + fluticasone with the pharmacy.
Terbinafine + Fluticasone is a generic medicine name and there are several brands available for it. Some of the brands for terbinafine + fluticasone might be better known than terbinafine + fluticasone itself. If the pharmacy that's willing to deliver medicines to your home doesn't have terbinafine + fluticasone in stock, you can ask for one of the branded alternatives for terbinafine + fluticasone.