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- Pharmacology For Miconazole + Clobetasone butyrate
Miconazole + Clobetasone butyrate Pharmacology
Miconazole + Clobetasone butyrate
About Miconazole + Clobetasone butyrateN/AMechanism of Action of Miconazole + Clobetasone butyrateN/APharmacokinets of Miconazole + Clobetasone butyrateN/AOnset of Action for Miconazole + Clobetasone butyrateN/ADuration of Action for Miconazole + Clobetasone butyrateN/AHalf Life of Miconazole + Clobetasone butyrateN/ASide Effects of Miconazole + Clobetasone butyrateN/AContra-indications of Miconazole + Clobetasone butyrateN/ASpecial Precautions while taking Miconazole + Clobetasone butyrateN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Miconazole + Clobetasone butyrateN/AInteractions for Miconazole + Clobetasone butyrateN/ATypical Dosage for Miconazole + Clobetasone butyrateN/ASchedule of Miconazole + Clobetasone butyrateN/AStorage Requirements for Miconazole + Clobetasone butyrateN/AEffects of Missed Dosage of Miconazole + Clobetasone butyrateN/AEffects of Overdose of Miconazole + Clobetasone butyrateN/AMiconazole
About MiconazoleAn imidazole derivative, Broad spectrum Antifungal.Mechanism of Action of MiconazoleMiconazole is fungicidal or fungistatic depending on the drug concentrations. I t inhibits the conversion of Lanosterol to 14 demethyl Lanosterol by inhibiting the cytochromeP450 enzyme 14 alpha demethylase and impair ergosterol synthesisPharmacokinets of MiconazoleAbsorption: Oral absorption of Miconazole is poor. Distribution: It is distributed in the body in protein bound form Metabolism: It undergoes metabolism in the liver. Excretion: It is excreted in urine and faeces.Onset of Action for MiconazoleN/ADuration of Action for MiconazoleN/AHalf Life of Miconazole1 daySide Effects of Miconazole1.Vulvovaginal burning
2.Burning
3.Irritation
4.Pruritis
5.Maceration
6.Dermatitis Contra-indications of Miconazole1.Hypersensitivity to Miconazole and other Azole antifungalsSpecial Precautions while taking Miconazole1.Hepatic dysfunctionPregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationUse with caution
NEONATES: contraindicated
Indications for Miconazole1.Tinea versicolor
2.Vulvovaginal candidiasis
3.Tinea pedis
4.Tinea corporis
5.Tinea cruris
6.Otomycosis
7.Onychomycosis
8.Oral candidiasis
9.Intestinal candidiasis
10.Diaper dermatitisInteractions for MiconazoleBenzoyl peroxide: Antibacterial synergism. Typical Dosage for MiconazoleAdult: Topical use:
Cutaneous infections: Apply the cream twice daily on the affected part for about 1 month
Tinea versicolor: Apply the cream once daily on the affected part
Vaginal use: Insert 300 mg suppository at bed time for 3 days or Insert 100 mg suppository at bed time for 7 days
CHILDREN:
Topical use:
Cutaneous infections: Apply the cream twice daily on the affected part for about 1 month
Tinea vericolor: Apply the cream once daily on the affected part
Schedule of MiconazoleHStorage Requirements for MiconazoleThe drug should be stored at 15 - 30 degree C.Effects of Missed Dosage of MiconazoleTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of MiconazoleGive supportive measures and treatment.
Clobetasone butyrate
About Clobetasone butyrateA new corticosteroid, Anti inflammatory.Mechanism of Action of Clobetasone butyrateClobetasone is a topical corticosteroid. It induces peptide Lipocortins which inhibit the enzyme Phospholipase A2. Phospholipase A2 is essential for the conversion of membrane phospholipids to Arachidonic acid. From this Arachidonic acid inflammatory mediators like prostaglandins, kinins, histamine, liposomal enzymes and the complement system are produced. By inhibiting Phospholipase A2 inflammatory mediators are not released. It also inhibits the migration of macrophages and leukocytes to the inflamed area by its vasoconstrictive properties. Corticosteroids also inhibit capillary production, collagen deposition and keloid (scar) formation on the inflamed area. Thus inhibiting inflammatory mediators and other actions Clobetasone are used for anti-inflammatory conditions.
Pharmacokinets of Clobetasone butyrateAbsorption: Clobetasone is absorbed through intact skin after topical administration and the amount absorbed is depending on the type of inflammation, vehicle used and the epidermal barrierOnset of Action for Clobetasone butyrateN/ADuration of Action for Clobetasone butyrateN/AHalf Life of Clobetasone butyrateN/ASide Effects of Clobetasone butyrate1.Thinning of epidermis
2.Burning
3.Itching
4.Irritation
5.Atrophy (Dermal changes)
6.Telangiectasia
7.Striae
8.Hypopigmentation
9.Contact dermatitis
10.Perioral dermatitis
11.Cataract, Glaucoma, Corneal ulcers Caused by application around eyelids and surrounding skinContra-indications of Clobetasone butyrate1.Hypersensitivity to Clobetasone and other corticosteroids
2.Acne vulgaris
3.Acne Rosacea
4.Nappy rash
5.Tuberculosis infection of the skin
6.Viral, fungal or bacterial primary infections
7.UlcersSpecial Precautions while taking Clobetasone butyrate1.Avoid application on large surface area
2.Prolonged use
3.Psoriasis
4.Avoid contact with eyes
5.Avoid occlusive dressing
6.Not used more than 5 days on the face or in the children, 6. For external use onlyPregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with caution
NEONATES: contraindicatedIndications for Clobetasone butyrateSkin disorders.
1.Otitis externa
2.Eczema
3.Dermatitis
4.Photodermatitis
5.Intertrigo (Inflammation in the skin folds)
6.Seborrheic dermatitis
7.Allergy or irritant dermatitis
8.Dermatoses (secondary infected)
9.Reaction to insect bite and stings
Interactions for Clobetasone butyrateN/ATypical Dosage for Clobetasone butyrateTopical: Clobetasone 0.05 % cream is used. Apply the medicament thinly and evenly on the affected area 3- 4 times daily. Maximum drug100 g / weekSchedule of Clobetasone butyrateN/AStorage Requirements for Clobetasone butyrateStore at room temperature. Protect from heat and light. Keep out of the reach of childrenEffects of Missed Dosage of Clobetasone butyrateApply the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Clobetasone butyrateGive supportive measures and symptomatic treatment.Home Delivery for Miconazole + Clobetasone butyrate in Your City
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