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- Pharmacology For Clotrimazole + Beclomethasone dipropionate
Clotrimazole + Beclomethasone dipropionate Pharmacology
Clotrimazole + Beclomethasone dipropionate
About Clotrimazole + Beclomethasone dipropionateN/AMechanism of Action of Clotrimazole + Beclomethasone dipropionateN/APharmacokinets of Clotrimazole + Beclomethasone dipropionateN/AOnset of Action for Clotrimazole + Beclomethasone dipropionateN/ADuration of Action for Clotrimazole + Beclomethasone dipropionateN/AHalf Life of Clotrimazole + Beclomethasone dipropionateN/ASide Effects of Clotrimazole + Beclomethasone dipropionateN/AContra-indications of Clotrimazole + Beclomethasone dipropionateN/ASpecial Precautions while taking Clotrimazole + Beclomethasone dipropionateN/APregnancy Related InformationUse with cautionOld Age Related InformationN/ABreast Feeding Related InformationUse with cautionChildren Related InformationN/AIndications for Clotrimazole + Beclomethasone dipropionateIt is a combination of imidazole antifungal Clotrimazole and corticosteroid Beclomethasone dipropionate.
1.Candidiasis
2.Inflammatory dermatoses
Interactions for Clotrimazole + Beclomethasone dipropionateN/ATypical Dosage for Clotrimazole + Beclomethasone dipropionateApply the medicament to the affected area twice dailySchedule of Clotrimazole + Beclomethasone dipropionateN/AStorage Requirements for Clotrimazole + Beclomethasone dipropionateN/AEffects of Missed Dosage of Clotrimazole + Beclomethasone dipropionateN/AEffects of Overdose of Clotrimazole + Beclomethasone dipropionateN/AClotrimazole
About ClotrimazoleA broad-spectrum antifungal antibiotic, imidazole derivative, Oral Nonabsorbed Antifungal Agent.Mechanism of Action of ClotrimazoleClotrimazole is fungicidal or fungistatic depending on the drug concentrations. It inhibits the conversion of Lanosterol to 14 demethyl Lanosterol by inhibiting the cytochromeP450 enzyme 14 alpha demethylase and impair ergosterol synthesis which is an essential constituent of cell membrane. Inhibition of ergosterol synthesis will alter the membrane permeability of the susceptible fungus and kill or inhibit them.Pharmacokinets of ClotrimazoleAbsorption: Absorption is minimal after topical administration.Onset of Action for ClotrimazoleN/ADuration of Action for Clotrimazole3 hoursHalf Life of ClotrimazoleN/ASide Effects of Clotrimazole1.Stinging
2.Erythema
3.Burning
4.Pruritis
5.Vesication
6.Desquamation
7.Urticaria
8.Burning
9.Peeling
10.Irritation
Contra-indications of ClotrimazoleHypersensitivity to ClotrimazoleSpecial Precautions while taking Clotrimazole1.Avoid contact with eyes, nose and mouth.
2.Do not wear occlusive dress over the medicament.
Pregnancy Related InformationUse with caution.Old Age Related InformationUse with caution.Breast Feeding Related InformationUse with caution.Children Related InformationUse with caution.
NEONATES: contraindicatedIndications for Clotrimazole1.Tinea pedis
2.Tinea cruris
3.Tinea versicolor
4.Tinea corporis
5.Cutaneous candidiasis
6.Vulvovaginal candidiasis
Interactions for ClotrimazolePolyene Antibiotics : Antagonises effects of polyene antibiotics.Typical Dosage for ClotrimazoleTopical: Clotrimazole cream, lotion and solution 1 % is used.
Clean and dry the affected area and apply the medicament with gentle massage 2 -3 times daily for 2 - 4 weeks.
Vaginal candidiasis: Insert 1 applicator full (vaginal cream 1%) intravaginally at night for 1 -2 weeks.
Vaginal tablets 100. 200 and 500mg tablet is available.
Vulvovaginal candidiasis: Insert 100mg tablet intravaginally at bed time for 7 consecutive days or 200 mg tablet for 3 consecutive days or 500 mg tablet for 1 day at night.
Oral lozenge 10 mg is available
Oropharyngeal candidiasis: 1 lozenge orally 5 times daily for 2 weeks
Prophylaxis of Oropharyngeal candidiasis: 1 lozenge is used 3 times daily
Gel: Insert with an applicator intravaginally at night for 1 - 2 weeks.
Powder (1% w/ w): dusted over the body parts as required
Schedule of ClotrimazoleHStorage Requirements for ClotrimazoleStore at room temperature (15 - 25 degree C). Protect from heat and moisture. Keep out of the reach of childrenEffects of Missed Dosage of ClotrimazoleApply the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of ClotrimazoleGive supportive measures and symptomatic treatment.Beclomethasone dipropionate
About Beclomethasone dipropionatePotent glucocorticoid, Potent anti-inflammatory agent in respiratory tract and nasal passages.Mechanism of Action of Beclomethasone dipropionateMechanism of action: The drug exerts its pharmacological action by penetrating and binding to cytoplasmic receptor protein and causes a structural change in steroid receptor complex. This structural change allows it`s migration in to the nucleus and then binding to specific sites on the DNA which leads to transcription of specific m-RNA and which ultimately regulates protein synthesis. It exerts highly selective glucocorticoid action. It stimulates the enzymes needed to decrease the inflammatory response.
The drug exerts anti-inflammatory and immunosuppressant actions as follows: - 1) Induce lipocortins in macrophages, endothelium, and fibroblasts which inhibits Phospholipase A2 and thus decreases the production of Prostaglandins, leukotrienes (LT), and platelet activating factor, 2) Causes negative regulation of genes for cytokines in macrophages, endothelial cells and lymphocytes and thus decreases the production of interleukins (IL-1, IL-2, IL-3, IL-6), TNF-alpha, GM-CSF (granulocyte macrophage colony stimulating factor), Gama interferon and suppresses fibroblast proliferation and T-lymphocyte functions and interferes chemo taxis. 3) Decreases the production of acute phase reactants from macrophages and endothelial cells and interferes complement function. 4) Decreases the production of ELAM-1(Endothelial leukocyte adhesion molecule-1) and ICAM-1(intracellular adhesion molecule-1) in endothelial cells. 5) Inhibit IgE mediated histamine and LT-C4 release from basophiles and the effects of antigen-antibody reaction is not mediated 6) Reduces the production of collagenase and stromolysin and thus prevents tissue destruction.
Pharmacokinets of Beclomethasone dipropionateAbsorption: It enters in to the systemic circulation after topical administration.Onset of Action for Beclomethasone dipropionateN/ADuration of Action for Beclomethasone dipropionateN/AHalf Life of Beclomethasone dipropionateN/ASide Effects of Beclomethasone dipropionate1.Thinning of the skin
2.Loss of elasticity
3.Increased hair growth
4.Acne at the site of application
5.Mild depigmentation
6.Rosacea
Contra-indications of Beclomethasone dipropionate1.Hypersensitivity to Beclomethasone
2.Untreated bacterial virus or fungal infections
3.Acne vulgaris
4.Peri-oral dermatitis
5.Tuberculosis of the skin
6.Varicose ulcers
7.Skin lesions caused by infections with herpes simplex vaccinia or varicella viruses. fungi (e.g. Candida Tinea) or bacteria (e.g. impetigo)
8.Discoid lupus Erythematosus
Special Precautions while taking Beclomethasone dipropionate1.Avoid contact with eyes
2.For external use only
3.Prolonged use
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with caution
NEONATES: contraindicatedIndications for Beclomethasone dipropionate1.Eczema
2.Psoriasis
3.Contact dermatitis
4.Anal and vulval Pruritis
5.Inflammation of the skin
Interactions for Beclomethasone dipropionateThere are no known drug interactions with topical betamethasone dipropionate.
Typical Dosage for Beclomethasone dipropionateTopical: Apply 0.025 %w/w cream as thin film 1 - 2times daily on to the affected areaSchedule of Beclomethasone dipropionateHStorage Requirements for Beclomethasone dipropionateStore below 25 degree C in a tightly closed container. Keep out of the reach of childrenEffects of Missed Dosage of Beclomethasone dipropionateApply the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Beclomethasone dipropionateGive supportive measures and symptomatic treatment.Home Delivery for Clotrimazole + Beclomethasone dipropionate in Your City
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Please be aware that you should take clotrimazole + beclomethasone dipropionate only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for clotrimazole + beclomethasone dipropionate before they complete the sale. You can get this information while placing the order for clotrimazole + beclomethasone dipropionate with the pharmacy.
Clotrimazole + Beclomethasone dipropionate is a generic medicine name and there are several brands available for it. Some of the brands for clotrimazole + beclomethasone dipropionate might be better known than clotrimazole + beclomethasone dipropionate itself. If the pharmacy that's willing to deliver medicines to your home doesn't have clotrimazole + beclomethasone dipropionate in stock, you can ask for one of the branded alternatives for clotrimazole + beclomethasone dipropionate.