Phenylbutazone + Paracetamol Pharmacology
Phenylbutazone + Paracetamol
Distribution- 98% bound to the plasma proteins.
Metabolism- Metabolized in the liver by oxidation and glucoronide conjugation.
Excretion- Excreted through urine.
Antirheumatic action: 3 to 4 days after oral administration
2. Epigastric distress
3. Aplastic anemia
4. Vomiting
5. Diarrhoea
6. Peptic ulcer
7. Depression
8. Neutropenia
9. Hypothyroidism
10. Skin rash
11. Urticaria
12. Oedema
2. Peptic ulcer
3. Hypertension
4. Congestive heart failure
5. Impairment of liver
6. Kidney dysfunction
7. Blood dyscrasias
8. Thyroid disease
2. Patients with Cardiac insufficiency
2. Ankylosing spondylitis
3. Gouty arthritis
4. Osteoarthritis
6. Tendinitis
7. Sprains
8. Strains
9. Menstrual cramps
10. Bursitis
Anti-inflammatory agents, Oral anticoagulants, Oral antidiabetics, Sulfonamides, Sodium valproate and Phenytoin: Duration of effect and toxicity of these drugs may be increased.
Barbiturates, Promethazine, Chlorpheniramine, Rifampicin and Corticosteroids: Decrease half life of phenylbutazone.
Cholestyramine: Enteral absorption of phenylbutazone reduced.
Coumarin-type anticoagulants: Hypo-prothrombonemic effects are increased by phenylbutazone.
Dicoumarol, Digoxin and Cortisone: May induce microsomal metabolism of phenylbutazone.
Phenytoin: Serum levels and toxicity of phenytoin increased.
Methotrexate, Insulin, Lithium: Effects of these drugs may be increased.
Lab tests: Reduces iodine uptake by thyroid and may interfere with laboratory tests of thyroid function.
Adults:
Initial dose- 200mg 2-3 times daily for 2 days.
Maintenance dose-100 mg 2-3 times daily.
Phenylbutazone
Distribution- 98% bound to the plasma proteins
Metabolism- Metabolized in the liver to its metabolites by oxidation and glucoronide conjugation
Excretion- Excreted through urine
Antirheumatic action -3 to 4 days after oral administration
2. Epigastric distress
3. Aplastic anemia
4. Vomiting
5. Diarrhoea
6. Peptic ulcer
7. Depression
8. Neutropenia
9. Hypothyroidism
10. Skin rash
11. Urticaria
12. Oedema.
2. Peptic ulcer
3. Hypertension
4. Congestive heart failure
5. Impairment of liver
6. Kidney dysfunction
7. Blood dyscriasis
8. Thyroid disease
Use with caution in patients with Cardiac insufficiency
2. Ankylosing spondylitis
3. Gouty arthritis
4. Osteoarthritis.
6. Tendinitis
7. Sprains
8.Strains
9. Menstrual cramps
10 Bursitis
Adults (General dose) -
Initial dose- 200mg 2-3 times daily for 2 days
Maintenance dose-100 mg 2 - 3 times daily
Paracetamol
It is more active on cyclo-oxygenase enzyme in brain. Peripherally it is a poor inhibitor of prostaglandin synthesis.
Analgesic action: Paracetamol raises the pain threshold and produces analgesic effect.
Antipyretic action: Paracetamol lowers fever by direct action on the thermoregulatory centre in the Hypothalamus and block the effects of endogenous pyrogen.
Distribution: It is distributed mostly in the body in unbound form.
Metabolism: It is extensively metabolised in the liver.
Excretion: Excreted in the urine.
2. Abdominal distress
3. Allergic reactions
4. Rash
2. Renal impairment
3. Hypertension
NEONATES : Contraindicated
2. Acute gout
3. Migraine
Charcoal: Activated, administered immediately reduces absorption of paracetamol.
Domperidone and metochlopramide: Enhance absorption of paracetamol.
Alcohol: Chronic excessive ingestion of alcohol potentiates hepatotoxicity of paracetamol.
Zidovudine: Effects zidovudine may be decreased.
500 - 1000 mg in 3 times daily
Maximum dose: 4 g / day
For migraine: 500 mg to be taken at the first sign of migraine attack and repeated 4 - 6 hourly until suppress mild attacks.
Children:
60 mg / kg body weight /day in 4 divided doses.
Maintenance dose: 75 mg / kg orally every 4 - 6 hours for 2 - 3 days. Haemodialysis can be done in emergency conditions.
Home Delivery for Phenylbutazone + Paracetamol in Your City
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