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- Pharmacology For Clotrimazole + Selenium Sulphide
Clotrimazole + Selenium Sulphide Pharmacology
Clotrimazole + Selenium Sulphide
About Clotrimazole + Selenium SulphideThis drug is a combination of antifungals Clotrimazole and Selenium Sulphide.
Clotrimazole- Clotrimazole is an antifungal. This act as fungicidal or fungistatic (depends on the drug concentrations).
Selenium Sulphide- Selenium sulfide is an antifungal. This produces antimitotic (cytostatic) action on cells of the Fungus.
Mechanism of Action of Clotrimazole + Selenium SulphideN/APharmacokinets of Clotrimazole + Selenium SulphideN/AOnset of Action for Clotrimazole + Selenium SulphideN/ADuration of Action for Clotrimazole + Selenium SulphideN/AHalf Life of Clotrimazole + Selenium SulphideN/ASide Effects of Clotrimazole + Selenium SulphideN/AContra-indications of Clotrimazole + Selenium SulphideN/ASpecial Precautions while taking Clotrimazole + Selenium SulphideN/APregnancy Related InformationUse with cautionOld Age Related InformationN/ABreast Feeding Related InformationUse with cautionChildren Related InformationN/AIndications for Clotrimazole + Selenium Sulphide1.Dandruff
2.Seborrheic dermatitis
Interactions for Clotrimazole + Selenium SulphideN/ATypical Dosage for Clotrimazole + Selenium SulphideApply the medicament to the affected part once dailySchedule of Clotrimazole + Selenium SulphideN/AStorage Requirements for Clotrimazole + Selenium SulphideN/AEffects of Missed Dosage of Clotrimazole + Selenium SulphideN/AEffects of Overdose of Clotrimazole + Selenium SulphideN/AClotrimazole
About ClotrimazoleA broad-spectrum antifungal antibiotic, imidazole derivative, Oral Nonabsorbed Antifungal Agent.Mechanism of Action of ClotrimazoleClotrimazole is fungicidal or fungistatic depending on the drug concentrations. It inhibits the conversion of Lanosterol to 14 demethyl Lanosterol by inhibiting the cytochromeP450 enzyme 14 alpha demethylase and impair ergosterol synthesis which is an essential constituent of cell membrane. Inhibition of ergosterol synthesis will alter the membrane permeability of the susceptible fungus and kill or inhibit them.Pharmacokinets of ClotrimazoleAbsorption: Absorption is minimal after topical administration.Onset of Action for ClotrimazoleN/ADuration of Action for Clotrimazole3 hoursHalf Life of ClotrimazoleN/ASide Effects of Clotrimazole1.Stinging
2.Erythema
3.Burning
4.Pruritis
5.Vesication
6.Desquamation
7.Urticaria
8.Burning
9.Peeling
10.Irritation
Contra-indications of ClotrimazoleHypersensitivity to ClotrimazoleSpecial Precautions while taking Clotrimazole1.Avoid contact with eyes, nose and mouth.
2.Do not wear occlusive dress over the medicament.
Pregnancy Related InformationUse with caution.Old Age Related InformationUse with caution.Breast Feeding Related InformationUse with caution.Children Related InformationUse with caution.
NEONATES: contraindicatedIndications for Clotrimazole1.Tinea pedis
2.Tinea cruris
3.Tinea versicolor
4.Tinea corporis
5.Cutaneous candidiasis
6.Vulvovaginal candidiasis
Interactions for ClotrimazolePolyene Antibiotics : Antagonises effects of polyene antibiotics.Typical Dosage for ClotrimazoleTopical: Clotrimazole cream, lotion and solution 1 % is used.
Clean and dry the affected area and apply the medicament with gentle massage 2 -3 times daily for 2 - 4 weeks.
Vaginal candidiasis: Insert 1 applicator full (vaginal cream 1%) intravaginally at night for 1 -2 weeks.
Vaginal tablets 100. 200 and 500mg tablet is available.
Vulvovaginal candidiasis: Insert 100mg tablet intravaginally at bed time for 7 consecutive days or 200 mg tablet for 3 consecutive days or 500 mg tablet for 1 day at night.
Oral lozenge 10 mg is available
Oropharyngeal candidiasis: 1 lozenge orally 5 times daily for 2 weeks
Prophylaxis of Oropharyngeal candidiasis: 1 lozenge is used 3 times daily
Gel: Insert with an applicator intravaginally at night for 1 - 2 weeks.
Powder (1% w/ w): dusted over the body parts as required
Schedule of ClotrimazoleHStorage Requirements for ClotrimazoleStore at room temperature (15 - 25 degree C). Protect from heat and moisture. Keep out of the reach of childrenEffects of Missed Dosage of ClotrimazoleApply the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of ClotrimazoleGive supportive measures and symptomatic treatment.Selenium Sulphide
About Selenium SulphideSelenium compound, Antifungal,anti-dandruff,in seborrheic dermatitis.Mechanism of Action of Selenium SulphideTopical Selenium sulfide produces antimitotic (cytostatic) action on cells of the epidermis and follicular epithelium and causes a reduction in the turnover of epidermal cells and reduces corneocyte production.
It also has local irritant, antibacterial and mild antifungal activity. Selenium sulfide is an antifungal agent often used in shampoos for the treatment of dandruff and Seborrheic dermatitis. Selenium sulfide inhibits the growth of P. ovale. It slows the growth of both hyperproliferative and normal cells in dandruff and Seborrheic dermatitis. Selenium sulfide decreases the rate of incorporation of radioactively labeled Thymidine into the DNA of dermal epithelial cells.
Selenium sulphide specifically destroys dermatophyte. It also causes a decrease in the production of cells in the top layer of skin, as well as the amount of natural oil sebum produced by the sebaceous glands in the skin. Selenium sulphide therefore kills the fungi responsible for causing this inflammation, as well as controls the itching and scaling associated with dandruff and Seborrheic dermatitis of the scalp.
Pharmacokinets of Selenium SulphideAbsorption: Absorption through intact skin is negligible.Onset of Action for Selenium SulphideN/ADuration of Action for Selenium SulphideN/AHalf Life of Selenium SulphideN/ASide Effects of Selenium Sulphide1. Alopecia (Hair loss)
2. Irritation
3. Sensitisation
4. Hair discoloration
5. Oiliness or dryness of scalp and hair
Contra-indications of Selenium Sulphide1. Hypersensitivity to Selenium sulphide
2. Broken skin or open wounds
3. Inflamed skin
Special Precautions while taking Selenium Sulphide1. Avoid contact with eyes.
2. Gold, silver and other metallic jewellery should be removed prior to use.
3. This preparation should be thoroughly rinsed from the hair before dyeing, tinting or waving the hair. It should not be applied for a period of two days before or after any of these procedures
4. For external use only.
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with caution
NEONATES: ContraindicatedIndications for Selenium SulphideScalp disorders
1. Dandruff
2. Seborrhoeic dermatitis
3. Tinea versicolor
Interactions for Selenium SulphideN/ATypical Dosage for Selenium SulphideTopical: Selenium sulphide 2.5% lotion or shampoo is used.
Tinea versicolor: Apply once daily for 1 week.
Seborrheic dermatitis and dandruff: Apply twice weekly for 2 weeks then gradually decrease the dose like once weekly, every 2 weeks
Schedule of Selenium SulphideN/AStorage Requirements for Selenium SulphideStore at cool place in a tightly closed container. Keep out of the reach of children.Effects of Missed Dosage of Selenium SulphideApply the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Selenium SulphideGive supportive measures and symptomatic treatment.Home Delivery for Clotrimazole + Selenium Sulphide in Your City
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Clotrimazole + Selenium Sulphide is a generic medicine name and there are several brands available for it. Some of the brands for clotrimazole + selenium sulphide might be better known than clotrimazole + selenium sulphide itself. If the pharmacy that's willing to deliver medicines to your home doesn't have clotrimazole + selenium sulphide in stock, you can ask for one of the branded alternatives for clotrimazole + selenium sulphide.