- Medicine India
- Generic Medicines
- K
- Pharmacology For Ketoconazole + Zinc pyrithione
Ketoconazole + Zinc pyrithione Pharmacology
Ketoconazole + Zinc pyrithione
About Ketoconazole + Zinc pyrithioneN/AMechanism of Action of Ketoconazole + Zinc pyrithioneN/APharmacokinets of Ketoconazole + Zinc pyrithioneN/AOnset of Action for Ketoconazole + Zinc pyrithioneN/ADuration of Action for Ketoconazole + Zinc pyrithioneN/AHalf Life of Ketoconazole + Zinc pyrithioneN/ASide Effects of Ketoconazole + Zinc pyrithioneN/AContra-indications of Ketoconazole + Zinc pyrithioneN/ASpecial Precautions while taking Ketoconazole + Zinc pyrithioneN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Ketoconazole + Zinc pyrithioneN/AInteractions for Ketoconazole + Zinc pyrithioneN/ATypical Dosage for Ketoconazole + Zinc pyrithioneN/ASchedule of Ketoconazole + Zinc pyrithioneN/AStorage Requirements for Ketoconazole + Zinc pyrithioneN/AEffects of Missed Dosage of Ketoconazole + Zinc pyrithioneN/AEffects of Overdose of Ketoconazole + Zinc pyrithioneN/AKetoconazole
About KetoconazoleImidazole derivative, A broad spectrum Antifungal.Mechanism of Action of KetoconazoleKetoconazole is fungicidal or fungistatic depending on concentrations. I t inhibits the conversion of Lanosterol to 14 demethyl Lanosterol by inhibiting the cytochromeP450 enzyme 14 alpha demethylase and impair ergosterol synthesis. This will alter cell membrane and its permeability. This will results in loss of intracellular components. It also inhibits biosynthesis of triglycerides and phospholipids by fungi. It also inhibits several enzymes (e.g. Oxidative and peroxidative enzymes) which are involved in detoxification process. This will leads to cellular necrosis.
Pharmacokinets of KetoconazoleAbsorption: It is absorbed only in acidic PH.Distribution: It is distributed in the body in protein bound form. Metabolism: It is metabolised to inactive metabolite in the liver. Excretion: It is excreted mainly through faeces and also through urine.
Onset of Action for KetoconazoleN/ADuration of Action for Ketoconazole1 dayHalf Life of Ketoconazole8 hour.Side Effects of Ketoconazole1.Dizziness
2.Headach
3.Nausea
4.Vomiting
5.Diarrhoea
6.Anorexia
7.Gynecomastia
8.Loss of hair
9.Libido
10.Leucopenia
11.Pruritis
12.Psychiatric problemsContra-indications of Ketoconazole1.Hypersensitivity to KetoconazoleSpecial Precautions while taking KetoconazoleHepatic dysfunctionPregnancy Related InformationContraindicated.Old Age Related InformationUse with caution.Breast Feeding Related InformationContraindicated.Children Related InformationAbove 2 years:use with caution
Below 2 years:contraindicated
NEONATES: contraindicated
Indications for Ketoconazole1.Vaginal candidiasis
2. Oral thrush
3.Candiduria
4.Histoplasmosis
5.Coccidioidomycosis
6.Paracoccidioidomycosis
8.Blastomycosis
9.Tinea pedis
10.Tinea corporis
11.Tinea cruris
12.Tinea vesicolor
13.Prostatic carcinoma
14.Dandruff
15. Seborrheic dermatitisInteractions for KetoconazoleAntacids & Histamine H2 antagonists: Increased gastric pH may inhibit ketoconazole absorption.
Isoniazid: The bioavailability of Ketoconazole may be decreased.
Rifampicin: Decreased serum levels of either drug may occur.
Oral anticoagulants: Anticoagulants response may be enhanced.
Corticosteroids: Bioavailability of corticosteroids increased and clearance may be decreased, resulting in possible toxicity.
Cyclosporine: Efficacy of cyclosporine enhanced leading to nephrotoxicity. May be used beneficially to reduce dose of cyclosporine in some patients.
Theophelline: Serum levels of theophylline may be decreased.
Alcohol: Nausea and acute facial flushing.
Typical Dosage for KetoconazoleAdult: 200 - 400 mg once daily
Prostate carcinoma: 1.2 g in 3 divided dose.
TOPICAL PREPARATIONS
For the treatment of Tinea infections apply once or twice daily on the affected part for 14 days.
Seborrheic dermatitis: apply Ketoconazole twice daily for 1 month
Dandruff: Apply for 60 seconds and rinse well. Reapply for 180 seconds. Apply twice weekly for 1 month
CHILDREN>2 years: 3.3 - 6.6 mg / kg body weight / day
TOPICAL PREPARATIONS
For the treatment of Tinea infections apply once or twice daily on the affected part for 14 days.
For Tinea pedis, apply for 1 ? month.
Seborrheic dermatitis: apply Ketoconazole twice daily for 1 month
Schedule of KetoconazoleHStorage Requirements for KetoconazoleThe drug should be stored in room temperature. Keep away from moisture and sunlight.Effects of Missed Dosage of KetoconazoleTake the missed dose as soon as noticed and if it is the time to take the next dose then skip the missed dose and continue the regular scheduleEffects of Overdose of KetoconazoleGive supportive measures and treatment. Induce emesis or gastric lavage has to be done followed by activated charcoal and a cathartic.Zinc pyrithione
About Zinc pyrithioneZinc compound, Anti-psoriatic, anti-fungal, antiseptic,keratolytic,Anti dandruff.Mechanism of Action of Zinc pyrithioneZinc pyrithione is used on psoriasis and seborrheic dermatitis due to its anti-proliferative, anti-yeast, antiseptic and keratolytic mechanisms.Zinc pyrithione has bacteriostatic and fungistatic actions.It reduces scaling and itching associated in psoriasis and seborrheic dermatitis.
Anti-proliferative mechanism of action of zinc pyrithione involve the regulation of DNA transcription factors containing "zinc finger" binding domains. It is also well recognized that many enzymes require the binding of metal ions for activation. One of these zinc requiring enzymes or transcription factors plays a key role in the regulation of cellular proliferation. It also has antibacterial properties and is effective against many pathogens from the streptococcus and staphylococcus class. It is used usually in combination with Ketoconazole for dandruff.
Pharmacokinets of Zinc pyrithioneN/AOnset of Action for Zinc pyrithioneN/ADuration of Action for Zinc pyrithioneN/AHalf Life of Zinc pyrithioneN/ASide Effects of Zinc pyrithione1.Discolouration of hair
2.Increase in normal hair loss
3.Irritation
4.Mild dryness of skin
5.Itching
6.Oilyness / dryness of hair and scalp
7.Peripheral neuritis
Contra-indications of Zinc pyrithioneHypersensitivity to Zinc pyrithioneSpecial Precautions while taking Zinc pyrithioneFor external use onlyPregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationContraindicatedIndications for Zinc pyrithione1. Dandruff
2. Seborrheic dermatitis
3. Psoriasis
4. Eczema
5. Ringworm
6. Athletes foot
7. Dry skin
8. Atypical dermatitis
9. Vitiligo
Interactions for Zinc pyrithioneN/ATypical Dosage for Zinc pyrithioneWet hair and scalp and apply sufficient shampoo to produce enough lather. Massage for one minute and rinse with warm water. Repeat procedure for 3 more minutes. Rinse with warm water and dry hair. Use shampoo twice a week for one month followed by once weekly as maintenance therapy. Schedule of Zinc pyrithioneN/AStorage Requirements for Zinc pyrithioneStore in a cool dry place. Protect from heat and light. Keep out of reach of children. Keep the medicine from freezing.Effects of Missed Dosage of Zinc pyrithioneApply the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Zinc pyrithioneGive supportive measures and symptomatic treatment.Home Delivery for Ketoconazole + Zinc pyrithione in Your City
Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including ketoconazole + zinc pyrithione.
However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for ketoconazole + zinc pyrithione and other medicines and health products. Home delivery services for ketoconazole + zinc pyrithione may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
Please be aware that you should take ketoconazole + zinc pyrithione only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for ketoconazole + zinc pyrithione before they complete the sale. You can get this information while placing the order for ketoconazole + zinc pyrithione with the pharmacy.
Ketoconazole + Zinc pyrithione is a generic medicine name and there are several brands available for it. Some of the brands for ketoconazole + zinc pyrithione might be better known than ketoconazole + zinc pyrithione itself. If the pharmacy that's willing to deliver medicines to your home doesn't have ketoconazole + zinc pyrithione in stock, you can ask for one of the branded alternatives for ketoconazole + zinc pyrithione.