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- Pharmacology For Triamcinolone acetonide + Neomycin
Triamcinolone acetonide + Neomycin Pharmacology
Triamcinolone acetonide + Neomycin
About Triamcinolone acetonide + NeomycinN/AMechanism of Action of Triamcinolone acetonide + NeomycinN/APharmacokinets of Triamcinolone acetonide + NeomycinN/AOnset of Action for Triamcinolone acetonide + NeomycinN/ADuration of Action for Triamcinolone acetonide + NeomycinN/AHalf Life of Triamcinolone acetonide + NeomycinN/ASide Effects of Triamcinolone acetonide + NeomycinN/AContra-indications of Triamcinolone acetonide + NeomycinN/ASpecial Precautions while taking Triamcinolone acetonide + NeomycinN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Triamcinolone acetonide + NeomycinN/AInteractions for Triamcinolone acetonide + NeomycinN/ATypical Dosage for Triamcinolone acetonide + NeomycinN/ASchedule of Triamcinolone acetonide + NeomycinN/AStorage Requirements for Triamcinolone acetonide + NeomycinN/AEffects of Missed Dosage of Triamcinolone acetonide + NeomycinN/AEffects of Overdose of Triamcinolone acetonide + NeomycinN/ATriamcinolone acetonide
About Triamcinolone acetonideA synthetic glucocorticoid, Topical anti-inflammatory(steroidal).Mechanism of Action of Triamcinolone acetonideThe drug exerts it`s pharmacological action by penetrating and binding to cytoplasmic receptor protein and causes a structural change in steroid receptor complex. This structural change allows it`s migration in to the nucleus and then binding to specific sites on the DNA which leads to transcription of specific m-RNA and which ultimately regulates protein synthesis. It exerts more selective glucocorticoid action. It stimulates the enzymes needed to decrease the inflammatory response.
The drug exerts anti-inflammatory and immunosuppressant actions as follows: - 1) Induce lipocortins in macrophages, endothelium, and fibroblasts which inhibits phospholipase A2 and thus decreases the production of Prostaglandins, leukotriens (LT), and platelet activating factor, 2) Causes negative regulation of genes for cytokines in macrophages, endothelial cells and lymphocytes and thus decreases the production of interleukins (IL-1, IL-2, IL-3, IL-6), TNF-a, GM-CSF (granulocyte macrophage colony stimulating factor), Gama interferon and suppresses fibroblast proliferation and T-lymphocyte functions and interferes chemo taxis. 3) Decreases the production of acute phase reactants from macrophages and endothelial cells and interferes complement function. 4) Decreases the production of ELAM-1(Endothelial leukocyte adhesion molecule-1) and ICAM-1(intracellular adhesion molecule-1) in endothelial cells. 5) Inhibit IgE mediated histamine and LT-C4 release from basophiles and the effects of antigen-antibody reaction is not mediated 6) Reduces the production of collagenase and stromolysin and thus prevents tissue destruction.
Pharmacokinets of Triamcinolone acetonideAbsorption: Triamcinolone acetonide is absorbed after topical application. Distribution: It is distributed mainly in protein bound form. Metabolism: It is metabolized primarily in the liver. Excretion: It is excreted by the kidneys and small amount is excreted through bile also.Onset of Action for Triamcinolone acetonideN/ADuration of Action for Triamcinolone acetonideN/AHalf Life of Triamcinolone acetonideN/ASide Effects of Triamcinolone acetonide1.Burning
2.Itching
3.Irritation
4.Dryness
5.Folliculitis
6.Hypertrichosis
7.Acneiform eruptions
8.Hypopigmentation
9.Dermatitis
10.Secondary infection
11.Skin atrophy
Contra-indications of Triamcinolone acetonideHypersensitivity to Triamcinolone acetonideSpecial Precautions while taking Triamcinolone acetonide1.Occlusive dressingsPregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with cautionIndications for Triamcinolone acetonide1. Inflammations of corticosteroid-responsive dermatoses
2. Treatment of skin disorders: Dermatitis, Psoriasis
Interactions for Triamcinolone acetonideN/ATypical Dosage for Triamcinolone acetonideTopical application: Apply the cream on the affected area 2-4 times daily; depending on the severity of the condition. Schedule of Triamcinolone acetonideN/AStorage Requirements for Triamcinolone acetonideStore at room temperature at a range of 15 to 30 degree C. Protect from light and moisture. Keep out of reach of children.Effects of Missed Dosage of Triamcinolone acetonideApply the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Triamcinolone acetonideProvide symptomatic treatment and supportive measures.Neomycin
About NeomycinAn aminoglycoside, Antibiotic, Ammonium Detoxicant.Mechanism of Action of NeomycinThis aminoglycoside cause protein synthesis inhibition by "irreversibly" bind to specific 30S-subunit proteins and 16S rRNA. Specifically Neomycin binds to four nucleotides of 16S rRNA and a single amino acid of protein S12. This interferes with decoding site in the vicinity of nucleotide 1400 in 16S rRNA of 30S subunit. This region interacts with the wobble base in the anticodon of tRNA. This leads to interference with the initiation complex, misreading of mRNA so incorrect amino acids are inserted into the polypeptide leading to nonfunctional or toxic peptides and the breakup of polysomes into nonfunctional monosomes.Pharmacokinets of NeomycinAbsorption- Poorly absorbed after oral administration
Distribution- Rapidly distributed in the body after oral administration. 30% bound to the plasma proteins. It crosses the placenta
Metabolism- Not metabolized
Excretion- Excreted through urine and feces (primarily as unchanged form). It also excreted through breast milk
Onset of Action for Neomycin1 to 4 hr after oral administrationDuration of Action for Neomycin8hrs after oral administrationHalf Life of NeomycinIts plasma half life is 2 to 3 hrsSide Effects of Neomycin1. Rash
2. Diarrhoea
3. Inflammation of the large intestine (colitis)
4. Nausea
5. Vomiting
6. Ototoxicity
7. Damage to the kidneys
8. Damage to vestibular function within the ear
Contra-indications of Neomycin1. Hypersensitivity to the drug or any ingredients of it
2. Hypersensitivity to other amino glycosides
3. Intestinal obstruction
Special Precautions while taking Neomycin1. Impaired renal function
2. Neuromuscular disorder
3. Ulcerative bowel lesions
4. Extensive dermatologic conditions
5. Any other eye infection or condition
6. Glaucoma
7. Cataract surgery
8. Blockage of the bowel
9. Eighth-cranial-nerve disease (loss of hearing and/or balance)
10. Kidney disease
11. Myasthenia gravis
12. Parkinson`s disease
13. Ulcers of the bowel
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationUse with cautionIndications for Neomycin1. Coma due to liver disease
2. Preventing infection following surgery
3. Topical infections
4. Systemic infections
Interactions for NeomycinN/ATypical Dosage for NeomycinOphthalmic suspension:
Adults-
1 or 2 drops every three or four hours- For eye infection
Oral (solution, tablets):
Adults and teenagers-
1 to 3 grams every six hours for five or six days- coma from liver disease
Adults and teenagers-
1 gram every hour for four hours, then 1 gram every four hours for the rest of a twenty-four hour period; or 1 gram nineteen hours before surgery, 1 gram eighteen hours before surgery, and 1 gram nine hours before surgery- cleaning the bowel before surgery.
Children-
14.7 milligrams mg/kg or 6.7 mg/ pound every four hours for three days
Ear preparation:
Adults and children-
2 to 5 drops into ear canal 3 to 4 times daily for 7 to 10 days- External ear canal infection
Schedule of NeomycinCStorage Requirements for NeomycinEye preparations store in the refrigerator protected from strong light. Do not freeze. Others are stored at <250C. Keep out of reach of children.Effects of Missed Dosage of NeomycinTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of NeomycinGive symptomatic and supportive treatment. Provide haemodialysis or peritoneal dialysis to remove the drug. Treated with calcium salts or anticholinesterase to reverses neuromuscular blockade. Administer activated charcoal to prevent the further absorption of drugHome Delivery for Triamcinolone acetonide + Neomycin in Your City
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