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- Pharmacology For Neomycin + Clobetasol propionate
Neomycin + Clobetasol propionate Pharmacology
Neomycin + Clobetasol propionate
About Neomycin + Clobetasol propionateN/AMechanism of Action of Neomycin + Clobetasol propionateN/APharmacokinets of Neomycin + Clobetasol propionateN/AOnset of Action for Neomycin + Clobetasol propionateN/ADuration of Action for Neomycin + Clobetasol propionateN/AHalf Life of Neomycin + Clobetasol propionateN/ASide Effects of Neomycin + Clobetasol propionateN/AContra-indications of Neomycin + Clobetasol propionateN/ASpecial Precautions while taking Neomycin + Clobetasol propionateN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Neomycin + Clobetasol propionateN/AInteractions for Neomycin + Clobetasol propionateN/ATypical Dosage for Neomycin + Clobetasol propionateN/ASchedule of Neomycin + Clobetasol propionateN/AStorage Requirements for Neomycin + Clobetasol propionateN/AEffects of Missed Dosage of Neomycin + Clobetasol propionateN/AEffects of Overdose of Neomycin + Clobetasol propionateN/ANeomycin
About NeomycinAn aminoglycoside, Antibiotic, Ammonium Detoxicant.Mechanism of Action of NeomycinThis aminoglycoside cause protein synthesis inhibition by "irreversibly" bind to specific 30S-subunit proteins and 16S rRNA. Specifically Neomycin binds to four nucleotides of 16S rRNA and a single amino acid of protein S12. This interferes with decoding site in the vicinity of nucleotide 1400 in 16S rRNA of 30S subunit. This region interacts with the wobble base in the anticodon of tRNA. This leads to interference with the initiation complex, misreading of mRNA so incorrect amino acids are inserted into the polypeptide leading to nonfunctional or toxic peptides and the breakup of polysomes into nonfunctional monosomes.Pharmacokinets of NeomycinAbsorption- Poorly absorbed after oral administration
Distribution- Rapidly distributed in the body after oral administration. 30% bound to the plasma proteins. It crosses the placenta
Metabolism- Not metabolized
Excretion- Excreted through urine and feces (primarily as unchanged form). It also excreted through breast milk
Onset of Action for Neomycin1 to 4 hr after oral administrationDuration of Action for Neomycin8hrs after oral administrationHalf Life of NeomycinIts plasma half life is 2 to 3 hrsSide Effects of Neomycin1. Rash
2. Diarrhoea
3. Inflammation of the large intestine (colitis)
4. Nausea
5. Vomiting
6. Ototoxicity
7. Damage to the kidneys
8. Damage to vestibular function within the ear
Contra-indications of Neomycin1. Hypersensitivity to the drug or any ingredients of it
2. Hypersensitivity to other amino glycosides
3. Intestinal obstruction
Special Precautions while taking Neomycin1. Impaired renal function
2. Neuromuscular disorder
3. Ulcerative bowel lesions
4. Extensive dermatologic conditions
5. Any other eye infection or condition
6. Glaucoma
7. Cataract surgery
8. Blockage of the bowel
9. Eighth-cranial-nerve disease (loss of hearing and/or balance)
10. Kidney disease
11. Myasthenia gravis
12. Parkinson`s disease
13. Ulcers of the bowel
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationUse with cautionIndications for Neomycin1. Coma due to liver disease
2. Preventing infection following surgery
3. Topical infections
4. Systemic infections
Interactions for NeomycinN/ATypical Dosage for NeomycinOphthalmic suspension:
Adults-
1 or 2 drops every three or four hours- For eye infection
Oral (solution, tablets):
Adults and teenagers-
1 to 3 grams every six hours for five or six days- coma from liver disease
Adults and teenagers-
1 gram every hour for four hours, then 1 gram every four hours for the rest of a twenty-four hour period; or 1 gram nineteen hours before surgery, 1 gram eighteen hours before surgery, and 1 gram nine hours before surgery- cleaning the bowel before surgery.
Children-
14.7 milligrams mg/kg or 6.7 mg/ pound every four hours for three days
Ear preparation:
Adults and children-
2 to 5 drops into ear canal 3 to 4 times daily for 7 to 10 days- External ear canal infection
Schedule of NeomycinCStorage Requirements for NeomycinEye preparations store in the refrigerator protected from strong light. Do not freeze. Others are stored at <250C. Keep out of reach of children.Effects of Missed Dosage of NeomycinTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of NeomycinGive symptomatic and supportive treatment. Provide haemodialysis or peritoneal dialysis to remove the drug. Treated with calcium salts or anticholinesterase to reverses neuromuscular blockade. Administer activated charcoal to prevent the further absorption of drugClobetasol propionate
About Clobetasol propionateTopical adenocorticoid, Anti inflammatory.Mechanism of Action of Clobetasol propionateClobetasol is a topical corticosteroid. It induces peptide Lipocortins which inhibit the enzyme Phospholipase A2. Phospholipase A2 is essential for the conversion of membrane phospholipids to Arachidonic acid. From this Arachidonic acid inflammatory mediators like prostaglandins, kinins, histamine, liposomal enzymes and the complement system are produced. By inhibiting Phospholipase A2 inflammatory mediators are not released. It also inhibits the migration of macrophages and leukocytes to the inflamed area by its vasoconstrictive properties. Corticosteroids also inhibit capillary production, collagen deposition and keloid (scar) formation. Thus inhibiting inflammatory mediators and other actions Clobetasol are used for anti-inflammatory conditions.Pharmacokinets of Clobetasol propionateAbsorption: Clobetasol is absorbed through intact skin after topical administration and the amount absorbed is depending on the type of inflammation, vehicle used, amount of drug applied and the epidermal barrier (nature of skin)Onset of Action for Clobetasol propionateN/ADuration of Action for Clobetasol propionateN/AHalf Life of Clobetasol propionateN/ASide Effects of Clobetasol propionate1.Thinning of epidermis
2.Burning
3. Itching
4.Irritation
5.Atrophy (Dermal changes)
6.Telangiectasia
7.Striae
8.Hypopigmentation
9.Contact dermatitis
10.Perioral dermatitis
Contra-indications of Clobetasol propionate1.Hypersensitivity to Clobetasol and other corticosteroids
2.Acne vulgaris
3.Acne Rosacea
4.Nappy rash
5.Tuberculosis infection of the skin
6.Viral,fungal or bacterial primary infections
7.Ulcers
Special Precautions while taking Clobetasol propionate1.Avoid application on large surface area
2.Prolonged use
3.Psoriasis
4.Avoid contact with eyes,mouth and mucous membrane
5.Avoid occlusive dressing or plastic damage
6.Not used more than 5 days on the face or in the children
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with caution
Below12 years: ContraindicatedIndications for Clobetasol propionate1.Skin disorders
2.Eczema
3.Psoriasis
4.Alopecia areata
5.Inflammation of corticosteroid dermatoses (secondary infected)
6.Chronic discoid lupus Erythematosus
Interactions for Clobetasol propionateN/ATypical Dosage for Clobetasol propionateTopical: Clobetasol 0.05 % cream and gel are available. Medicament is applied thinly and evenly on the affected area. 2 times a day, maximum 2 weeks. Maximum dose: 50 g of the cream/ week. Schedule of Clobetasol propionateHStorage Requirements for Clobetasol propionateStore at room temperature. Protect from heat, moisture and light. Keep out of the reach of childrenEffects of Missed Dosage of Clobetasol propionateApply the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Clobetasol propionateGive supportive measures and symptomatic treatment.Home Delivery for Neomycin + Clobetasol propionate in Your City
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Neomycin + Clobetasol propionate is a generic medicine name and there are several brands available for it. Some of the brands for neomycin + clobetasol propionate might be better known than neomycin + clobetasol propionate itself. If the pharmacy that's willing to deliver medicines to your home doesn't have neomycin + clobetasol propionate in stock, you can ask for one of the branded alternatives for neomycin + clobetasol propionate.