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- Pharmacology For Clobetasol propionate + Gentamicin
Clobetasol propionate + Gentamicin Pharmacology
Clobetasol propionate + Gentamicin
About Clobetasol propionate + GentamicinN/AMechanism of Action of Clobetasol propionate + GentamicinN/APharmacokinets of Clobetasol propionate + GentamicinN/AOnset of Action for Clobetasol propionate + GentamicinN/ADuration of Action for Clobetasol propionate + GentamicinN/AHalf Life of Clobetasol propionate + GentamicinN/ASide Effects of Clobetasol propionate + GentamicinN/AContra-indications of Clobetasol propionate + GentamicinN/ASpecial Precautions while taking Clobetasol propionate + GentamicinN/APregnancy Related InformationContraindicated; since Clobetasol propionate is contraindicated in pregnancy, the combination generic cannot be used in pregnancy.Old Age Related InformationN/ABreast Feeding Related InformationContraindicated; since Clobetasol propionate is contraindicated in lactation, the combination generic cannot be used in breast feeding mother.Children Related InformationN/AIndications for Clobetasol propionate + GentamicinIt is a combination of corticosteroid Clobetasol propionate and antiinfective Gentamicin.
1.Inflammatory skin diseases
Interactions for Clobetasol propionate + GentamicinN/ATypical Dosage for Clobetasol propionate + GentamicinApply the cream as thin layer to the affected area 2 - 3 times daily. Treatment should not continue for more than 14 days.Schedule of Clobetasol propionate + GentamicinN/AStorage Requirements for Clobetasol propionate + GentamicinN/AEffects of Missed Dosage of Clobetasol propionate + GentamicinN/AEffects of Overdose of Clobetasol propionate + GentamicinN/AClobetasol propionate
About Clobetasol propionateTopical adenocorticoid, Anti inflammatory.Mechanism of Action of Clobetasol propionateClobetasol is a topical corticosteroid. It induces peptide Lipocortins which inhibit the enzyme Phospholipase A2. Phospholipase A2 is essential for the conversion of membrane phospholipids to Arachidonic acid. From this Arachidonic acid inflammatory mediators like prostaglandins, kinins, histamine, liposomal enzymes and the complement system are produced. By inhibiting Phospholipase A2 inflammatory mediators are not released. It also inhibits the migration of macrophages and leukocytes to the inflamed area by its vasoconstrictive properties. Corticosteroids also inhibit capillary production, collagen deposition and keloid (scar) formation. Thus inhibiting inflammatory mediators and other actions Clobetasol are used for anti-inflammatory conditions.Pharmacokinets of Clobetasol propionateAbsorption: Clobetasol is absorbed through intact skin after topical administration and the amount absorbed is depending on the type of inflammation, vehicle used, amount of drug applied and the epidermal barrier (nature of skin)Onset of Action for Clobetasol propionateN/ADuration of Action for Clobetasol propionateN/AHalf Life of Clobetasol propionateN/ASide Effects of Clobetasol propionate1.Thinning of epidermis
2.Burning
3. Itching
4.Irritation
5.Atrophy (Dermal changes)
6.Telangiectasia
7.Striae
8.Hypopigmentation
9.Contact dermatitis
10.Perioral dermatitis
Contra-indications of Clobetasol propionate1.Hypersensitivity to Clobetasol and other corticosteroids
2.Acne vulgaris
3.Acne Rosacea
4.Nappy rash
5.Tuberculosis infection of the skin
6.Viral,fungal or bacterial primary infections
7.Ulcers
Special Precautions while taking Clobetasol propionate1.Avoid application on large surface area
2.Prolonged use
3.Psoriasis
4.Avoid contact with eyes,mouth and mucous membrane
5.Avoid occlusive dressing or plastic damage
6.Not used more than 5 days on the face or in the children
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with caution
Below12 years: ContraindicatedIndications for Clobetasol propionate1.Skin disorders
2.Eczema
3.Psoriasis
4.Alopecia areata
5.Inflammation of corticosteroid dermatoses (secondary infected)
6.Chronic discoid lupus Erythematosus
Interactions for Clobetasol propionateN/ATypical Dosage for Clobetasol propionateTopical: Clobetasol 0.05 % cream and gel are available. Medicament is applied thinly and evenly on the affected area. 2 times a day, maximum 2 weeks. Maximum dose: 50 g of the cream/ week. Schedule of Clobetasol propionateHStorage Requirements for Clobetasol propionateStore at room temperature. Protect from heat, moisture and light. Keep out of the reach of childrenEffects of Missed Dosage of Clobetasol propionateApply the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Clobetasol propionateGive supportive measures and symptomatic treatment.Gentamicin
About GentamicinAminoglycoside antibiotic.Mechanism of Action of GentamicinGentamicin exerts its bactericidal action against gram negative organisms & some of gram positive organisms by inhibiting bacterial protein synthesis. The process involves 1. Penetration of bacterial cell membrane & binding directly to the bacterial ribosome, 2. Misleading of m-RNA codon by bacterial ribosome, 3. Formation of peptide chains with wrong amino acid sequence which gets incorporated into bacterial cell membrane and alters its permeability, 4. Bacterial cell lysis. Some bacterial strains resistant to other amino glycosides are sensitive to Gentamicin.
Pharmacokinets of GentamicinAbsorption: Poorly absorbed orally
Distribution: Distributed extracellularly. CSF penetration & intraocular penetration poor.
Metabolism: Not metabolized
Excretion: Excreted mainly through urine.
Onset of Action for Gentamicin1 hour
Duration of Action for Gentamicin8 hoursHalf Life of Gentamicin2 hoursSide Effects of Gentamicin1. Vestibular damage & Ototoxicity
2. Allergic manifestations
3. Nephrotoxicity
4. Dizziness
5. Nausea
6. Vomiting
7. Seizures
Contra-indications of Gentamicin1. Hypersensitive to the drug or other amino glycosides
2. Along with chloramphenicol or tetracycline
3. Renal impairment
4. Labyrinthine disorders
Special Precautions while taking Gentamicin1. Renal impairment
2. Neuromuscular disorders
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with caution
Breast Feeding Related InformationContraindicated
Children Related InformationUse with caution
Infants : Use with caution
Indications for Gentamicin1. Infections caused by staphylococci, pseudomonas, proteous, klebsiella, enterobacter & serratia.
2. Meningitis.
3. Endocarditis
4. Urinary Tract Infections.
5. Otitis & Ocular infections.
6. Infections of burns & Skin ulcers
Interactions for GentamicinAmphotericin B, Cisplatin, Cephalosporin, Vancomycin, Methoxyflurane, Frusemide, Bumetanide: Increased nephrotoxicity.
Anaesthetics, Neuromuscular blocking agents (Tubocurarine): Risk of neuromuscular blockade and respiratory paralysis.
Penicillin, Cephalosporins, Carbenicillin, Ticarcillin: Exert antibiotic synergism, especially useful in Pseudomonas infections.
Loop diuretics: Concurrent use of these agents may increase the risk of respiratory paralysis and renal dysfunction.
Lab Tests: Aminoglycoside serum levels: Guard against in vitro inactivation of aminoglycosides by b-lactum antibiotics in patients on combination therapy.Typical Dosage for GentamicinDosage:
Adults: 2 to 5mg/kg/day; Thrice daily for a week or more
Children: 2 to 2.5mg/kg; Thrice daily.
Schedule of GentamicinHStorage Requirements for GentamicinStore below 30 degree Celsius and protect from light.Effects of Missed Dosage of GentamicinTake the missed dose as soon as noticed and if it is the time to next dose then skip the missed dose.Continue the regular schedule. Do not double the dose.Effects of Overdose of GentamicinAn overdose results in ototoxicity, nephrotoxicity, neuromuscular disorders & hypersensitivity manifestations.Treatment includes removal of drug by dialysis or by treatment with anticholinesterase like neostigmine and by administration of Ca , Prednisolone etc.
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