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- Pharmacology For Fusidic acid + Betamethasone valerate
Fusidic acid + Betamethasone valerate Pharmacology
Fusidic acid + Betamethasone valerate
About Fusidic acid + Betamethasone valerateN/AMechanism of Action of Fusidic acid + Betamethasone valerateN/APharmacokinets of Fusidic acid + Betamethasone valerateN/AOnset of Action for Fusidic acid + Betamethasone valerateN/ADuration of Action for Fusidic acid + Betamethasone valerateN/AHalf Life of Fusidic acid + Betamethasone valerateN/ASide Effects of Fusidic acid + Betamethasone valerateN/AContra-indications of Fusidic acid + Betamethasone valerateN/ASpecial Precautions while taking Fusidic acid + Betamethasone valerateN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Fusidic acid + Betamethasone valerateN/AInteractions for Fusidic acid + Betamethasone valerateN/ATypical Dosage for Fusidic acid + Betamethasone valerateN/ASchedule of Fusidic acid + Betamethasone valerateN/AStorage Requirements for Fusidic acid + Betamethasone valerateN/AEffects of Missed Dosage of Fusidic acid + Betamethasone valerateN/AEffects of Overdose of Fusidic acid + Betamethasone valerateN/AFusidic acid
About Fusidic acidA bacteriostatic Steroid Antibiotic, Systemic antibacterial, anti-infective.Mechanism of Action of Fusidic acidFusidic acid is a bactericidal or bacteriostatic drug depending upon the concentration. It inhibits the transfer of aminoacid from aminoacyl sRNA to the protein. This will leads to inhibition of protein synthesis in the bacteria and prevent the growth of microbes.Pharmacokinets of Fusidic acidAbsorption: It is very poorly absorbed after topical administration.Onset of Action for Fusidic acidNULL.Duration of Action for Fusidic acidNULL.Half Life of Fusidic acidN/ASide Effects of Fusidic acid1. Contact dermatitis
2. Irritation
3. Burning
4. Redness
5. Swelling
6. Rashes
Contra-indications of Fusidic acid1. Hypersensitivity to Fusidic acidSpecial Precautions while taking Fusidic acid1. Avoid contact with eyes
2. If irritation occurs discard the use of medicament
3. Hepatic impairment
4. Monitor liver function test
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationUse with cautionIndications for Fusidic acidPrimary and secondary skin infections
1. Impetigo
2. Erythrasma
3. Folliculitis
4. Sycosis barbae
5. Hidradenitis
Interactions for Fusidic acidNULL.Typical Dosage for Fusidic acidFusidic acid 2% cream or ointment .Clean and dry the affected area. Apply the drug as thin layer.2 - 4 times daily. Schedule of Fusidic acidN/AStorage Requirements for Fusidic acidStore in a cool dry place. Protect from heat and light. Keep out of the reach of childrenEffects of Missed Dosage of Fusidic acidApply the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Fusidic acidGive supportive measures and symptomatic treatment.Betamethasone valerate
About Betamethasone valerateIt is a topical steroid
Mechanism of Action of Betamethasone valerateThe drug exerts it`s pharmacological action by penetrating and binding to cytoplasmic receptor protein and causes a structural change in steroid receptor complex. This structural change allows it`s migration in to the nucleus and then binding to specific sites on the DNA which leads to transcription of specific m-RNA and which ultimately regulates protein synthesis. It exerts highly selective glucocorticoid action. It stimulates the enzymes needed to decrease the inflammatory response.
The drug exerts anti-inflammatory and immunosuppressant actions as follows: - 1) Induce lipocortins in macrophages, endothelium, and fibroblasts which inhibits phospholipase A2 and thus decreases the production of Prostaglandins, leukotriens (LT), and platelet activating factor, 2) Causes negative regulation of genes for cytokines in macrophages, endothelial cells and lymphocytes and thus decreases the production of interleukins (IL-1, IL-2, IL-3, IL-6), TNF-alpha, GM-CSF (granulocyte macrophage colony stimulating factor), Gama interferon and suppresses fibroblast proliferation and T-lymphocyte functions and interferes chemotaxis. 3) Decreases the production of acute phase reactants from macrophages and endothelial cells and interferes complement function. 4) Decreases the production of ELAM-1(Endothelial leukocyte adhesion molecule-1) and ICAM-1(intracellular adhesion molecule-1) in endothelial cells. 5) Inhibit IgE mediated histamine and LT-C4 release from basophiles and the effects of antigen-antibody reaction is not mediated 6) Reduces the production of collagenase and stromolysin and thus prevents tissue destruction.
Pharmacokinets of Betamethasone valerateAbsorption: It is absorbed in to the systemic circulation and the amount is depending on the potency, amount applied and the nature of the skin at the site of application. Absorption increases at the site of skin damage, inflammation or occlusion.
Onset of Action for Betamethasone valerateN/ADuration of Action for Betamethasone valerateN/AHalf Life of Betamethasone valerateN/ASide Effects of Betamethasone valerate1.Thinning of the skin
2.Loss of elasticity
3.Increased hair growth
4.Acne at the site of application
5.Mild depigmentation
6.Rosacea
Contra-indications of Betamethasone valerate1.Untreated bacterial, virus or fungal infections
2.Acne vulgaris,
3.Peri-oral dermatitis,
4.Scabies,
5.Leg ulcers,
6.Tuberculosis of the skin,
7.Varicose ulcers,
8.Skin lesions caused by infections with ring worm,. fungi (e.g. Candida, Tinea) or bacteria (e.g. impetigo)
9.Hypersensitivity to Betamethasone and other corticosteroids.
10.Discoid lupus Erythematosus
Special Precautions while taking Betamethasone valerate1.Avoid contact with eyes
2.For external use only
3.Prolonged use
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with caution
NEONATES: contraindicatedIndications for Betamethasone valerate1.Psoriasis,
2.Eczema,
3.Otitis externa,
4.Lichen simplex and planus,
5.Anal and vulval Pruritis,
6.Seborrheic dermatitis,
7.Contact dermatitis,
8.Steroidal responsive dermatoses of the scalp
Interactions for Betamethasone valerateN/ATypical Dosage for Betamethasone valerateTopical:
Betamethasone Valerate: Apply to the affected area as thin film 1 - 4 times daily depending upon the severity, skin and rate of absorption.
Dermatoses of the scalp: (Betamethasone Valerate 0.12%): Small amount of foam is applied in to the scalp with gentle massage 2 times a day for up to 2 weeks.
Schedule of Betamethasone valerateN/AStorage Requirements for Betamethasone valerateStore at room temperature in a well closed; light resistant container. Protect from excess heat and moisture. Keep out of reach of children.Effects of Missed Dosage of Betamethasone valerateApply the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Betamethasone valerateProvide symptomatic treatment and supportive measures.Home Delivery for Fusidic acid + Betamethasone valerate in Your City
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Fusidic acid + Betamethasone valerate is a generic medicine name and there are several brands available for it. Some of the brands for fusidic acid + betamethasone valerate might be better known than fusidic acid + betamethasone valerate itself. If the pharmacy that's willing to deliver medicines to your home doesn't have fusidic acid + betamethasone valerate in stock, you can ask for one of the branded alternatives for fusidic acid + betamethasone valerate.