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- Pharmacology For Mupirocin + Betamethasone dipropionate
Mupirocin + Betamethasone dipropionate Pharmacology
Mupirocin + Betamethasone dipropionate
About Mupirocin + Betamethasone dipropionateN/AMechanism of Action of Mupirocin + Betamethasone dipropionateN/APharmacokinets of Mupirocin + Betamethasone dipropionateN/AOnset of Action for Mupirocin + Betamethasone dipropionateN/ADuration of Action for Mupirocin + Betamethasone dipropionateN/AHalf Life of Mupirocin + Betamethasone dipropionateN/ASide Effects of Mupirocin + Betamethasone dipropionateN/AContra-indications of Mupirocin + Betamethasone dipropionateN/ASpecial Precautions while taking Mupirocin + Betamethasone dipropionateN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Mupirocin + Betamethasone dipropionateN/AInteractions for Mupirocin + Betamethasone dipropionateN/ATypical Dosage for Mupirocin + Betamethasone dipropionateN/ASchedule of Mupirocin + Betamethasone dipropionateN/AStorage Requirements for Mupirocin + Betamethasone dipropionateN/AEffects of Missed Dosage of Mupirocin + Betamethasone dipropionateN/AEffects of Overdose of Mupirocin + Betamethasone dipropionateN/AMupirocin
About MupirocinA naturally antibiotic isolated from Pseudomonas fluorescens, Antibiotic.Mechanism of Action of MupirocinMupirocin exerts its action by reversibly binding to isoleucyl transfer RNA synthetase and inhibits the enzyme activity. This enzyme is necessary for the synthesis of proteins in the bacteria. Inhibition of isoleucyl transfer RNA synthetase results in inhibition of protein synthesis and produce microbicidal action. It is more active against gram positive bacteria as compared to gram negative bacteria.Pharmacokinets of MupirocinAbsorption: Mupirocin is negligibly absorbed after topical administration.Onset of Action for MupirocinN/ADuration of Action for MupirocinN/AHalf Life of MupirocinN/ASide Effects of MupirocinTopical use :
1. Irritation
2. Burning
3. Rashes
4. Pruritis
5. Stinging
6. Erythema
7. Dryness
8. Dermatitis
9. Pain
Nasal use:
1. Rhinitis
2. Cough
3. Headache
4. Pharyngitis
5. Change in taste
6. Chest congestion
Contra-indications of Mupirocin1. Hypersensitivity to MupirocinSpecial Precautions while taking Mupirocin1. If sensitivity occurs discard the use of the medicament
2. Renal impairment
3. Patient with burns
4. Avoid contact with eyes and mucous membrane
5. Avoid application in the large surface area(extensive wound)
6. Monitor for super infection
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with caution
NEONATES : Use with cautionIndications for MupirocinBacterial skin infections:
1. Impetigo
2. Infected eczema
3. Folliculitis
4. Eradication of nasal colonization of Methicillin resistant S.aureus
Interactions for MupirocinN/ATypical Dosage for MupirocinAdult:
Topical use: 2% cream, and ointment: Wash and dry the affected area thoroughly. Apply the medicament as a thin film over the affected part. Rub gently. Cover with a surgical gauze. Apply 3 times daily for 1 - 2 weeks.
Intranasal use: 2 % ointment: Apply the half of the content of a single use tube in to one nostril and other half in to other nostril. Press the sides of the nostrils together and release it. Repeat it for 1 minute. Apply it morning and evening.
Schedule of MupirocinN/AStorage Requirements for MupirocinStore at room temperature in a tightly closed container. Keep away from moisture and heat. Keep out of the reach of children.Effects of Missed Dosage of MupirocinApply the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of MupirocinGive supportive measures and symptomatic treatment.Betamethasone dipropionate
About Betamethasone dipropionateA synthetic glucocorticoid, anti-inflammatory.Mechanism of Action of Betamethasone dipropionateThe drug exerts it`s pharmacological action by penetrating and binding to cytoplasmic receptor protein and causes a structural change in steroid receptor complex. This structural change allows it`s migration in to the nucleus and then binding to specific sites on the DNA which leads to transcription of specific m-RNA and which ultimately regulates protein synthesis. It exerts highly selective glucocorticoid action. It stimulates the enzymes needed to decrease the inflammatory response.
The drug exerts anti-inflammatory and immunosuppressant actions as follows: - 1) Induce lipocortins in macrophages, endothelium, and fibroblasts which inhibits phospholipase A2 and thus decreases the production of Prostaglandins, leukotriens (LT), and platelet activating factor, 2) Causes negative regulation of genes for cytokines in macrophages, endothelial cells and lymphocytes and thus decreases the production of interleukins (IL-1, IL-2, IL-3, IL-6), TNF-alpha, GM-CSF (granulocyte macrophage colony stimulating factor), Gama interferon and suppresses fibroblast proliferation and T-lymphocyte functions and interferes chemotaxis. 3) Decreases the production of acute phase reactants from macrophages and endothelial cells and interferes complement function. 4) Decreases the production of ELAM-1(Endothelial leukocyte adhesion molecule-1) and ICAM-1(intracellular adhesion molecule-1) in endothelial cells. 5) Inhibit IgE mediated histamine and LT-C4 release from basophiles and the effects of antigen-antibody reaction is not mediated 6) Reduces the production of collagenase and stromolysin and thus prevents tissue destruction.
Pharmacokinets of Betamethasone dipropionateAbsorption: It is absorbed in to the systemic circulation and the amount is depending on the potency, amount applied and the nature of the skin at the site of application. Absorption increases at the site of skin damage, inflammation or occlusion.
Onset of Action for Betamethasone dipropionateN/ADuration of Action for Betamethasone dipropionateN/AHalf Life of Betamethasone dipropionateN/ASide Effects of Betamethasone dipropionate1.Thinning of the skin
2.Loss of elasticity
3.Increased hair growth
4.Acne at the site of application
5.Mild depigmentation
6.Rosacea
Contra-indications of Betamethasone dipropionate1.Hypersensitivity to Betamethasone
2.Untreated bacterial virus or fungal infections
3.Acne vulgaris
4.Peri-oral dermatitis
5.Tuberculosis of the skin
6.Varicose ulcers
7.Skin lesions caused by infections with herpes simplex vaccinia or varicella viruses. fungi (e.g. Candida Tinea) or bacteria (e.g. impetigo)
8.Discoid lupus Erythematosus
Special Precautions while taking Betamethasone dipropionate1.Avoid contact with eyes
2.For external use only
3.Prolonged use
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with caution
NEONATES: contraindicatedIndications for Betamethasone dipropionate1.Eczema
2.Psoriasis
3.Contact dermatitis
4.Anal and vulval Pruritis
5.Inflammation of the skin
Interactions for Betamethasone dipropionateN/ATypical Dosage for Betamethasone dipropionateApply thinly 1 -2 times daily.Schedule of Betamethasone dipropionateHStorage Requirements for Betamethasone dipropionateStore at room temperature in a well closed; light resistant container. Protect from excess heat and moisture. Keep out of reach of children.Effects of Missed Dosage of Betamethasone dipropionateApply the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Betamethasone dipropionateProvide symptomatic treatment and supportive measures.Home Delivery for Mupirocin + Betamethasone dipropionate in Your City
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Mupirocin + Betamethasone dipropionate is a generic medicine name and there are several brands available for it. Some of the brands for mupirocin + betamethasone dipropionate might be better known than mupirocin + betamethasone dipropionate itself. If the pharmacy that's willing to deliver medicines to your home doesn't have mupirocin + betamethasone dipropionate in stock, you can ask for one of the branded alternatives for mupirocin + betamethasone dipropionate.