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- Pharmacology For Silver sulphadiazine + Chlorhexidine
Silver sulphadiazine + Chlorhexidine Pharmacology
Silver sulphadiazine + Chlorhexidine
About Silver sulphadiazine + ChlorhexidineN/AMechanism of Action of Silver sulphadiazine + ChlorhexidineN/APharmacokinets of Silver sulphadiazine + ChlorhexidineN/AOnset of Action for Silver sulphadiazine + ChlorhexidineN/ADuration of Action for Silver sulphadiazine + ChlorhexidineN/AHalf Life of Silver sulphadiazine + ChlorhexidineN/ASide Effects of Silver sulphadiazine + ChlorhexidineN/AContra-indications of Silver sulphadiazine + ChlorhexidineN/ASpecial Precautions while taking Silver sulphadiazine + ChlorhexidineN/APregnancy Related InformationContraindicatedOld Age Related InformationN/ABreast Feeding Related InformationContraindicatedChildren Related InformationN/AIndications for Silver sulphadiazine + ChlorhexidineIt is a combination of broad spectrum antibacterial Silver sulphadiazine and antiseptic Chlorhexidine. This combination will exert a potent anti-infective anti-septic and antimicrobial action against various skin infecting organisms.
1.Skin injuries like cuts, burns, wounds and bruises
2.Skin infections
Interactions for Silver sulphadiazine + ChlorhexidineN/ATypical Dosage for Silver sulphadiazine + ChlorhexidineApply the medicament on the affected areas 2 - 3 times a day.Schedule of Silver sulphadiazine + ChlorhexidineN/AStorage Requirements for Silver sulphadiazine + ChlorhexidineN/AEffects of Missed Dosage of Silver sulphadiazine + ChlorhexidineN/AEffects of Overdose of Silver sulphadiazine + ChlorhexidineN/ASilver Sulphadiazine
About Silver SulphadiazineA sulfa derivative, Silver compound, Antiseptic, topical antibacterial.Mechanism of Action of Silver SulphadiazineSilver sulphadiazine is a broad spectrum antiseptic. Silver is released from the drug and it penetrates the bacterial cell wall and bound to bacterial DNA and inhibits DNA replication.
The sulfadiazine moiety has synergistic action and also provides a bacteriostatic action against sensitive organisms
Pharmacokinets of Silver SulphadiazineAbsorption: After topical administration silver ions and sulphadiazine are released and small amount of sulphadiazine is absorbed in to the systemic circulation. Only a very small amount of silver is absorbed after topical administration
Onset of Action for Silver SulphadiazineNULL.Duration of Action for Silver SulphadiazineNULL.Half Life of Silver SulphadiazineN/ASide Effects of Silver Sulphadiazine1. Burning
2. Itching
3. Rashes
4. Systemic toxicity when applied on large surface area
5. Transient leucopenia (comes back to normal in 4 -5 days).
Contra-indications of Silver Sulphadiazine1. Hypersensitivity to Silver sulphadiazine and other Sulphonamide
2. Deep infections
Special Precautions while taking Silver Sulphadiazine1. Renal impairment
2. Hepatic impairment
3. G6PD deficiency
4. Withdraw the drug immediately if rashes appears
Pregnancy Related InformationContraindicated
Old Age Related InformationUse with cautionBreast Feeding Related InformationContraindicated
Children Related InformationUse with caution
NEONATES: Contraindicated
Indications for Silver Sulphadiazine1. Prevention and treatment of infections in Burns
2. Infected leg ulcers
3. Pressure sores
4. Prophylaxis of infections in skin graft donor sites
5. Preventions of infections in abrasions
6. Wounds
Interactions for Silver SulphadiazineCyclosporine: Decreased efficacy and increased nephrotoxicity with cotrimoxazole.
Methotrexate: Bone marrow depressant effect potentiated.
Phenytoin: Half-life prolonged.
Sulfonylureas: Increased hypoglycemic effect.
Thiazide diuretics: Increased risk of thrombocytopenic purpura in elderly.
Warfarin: Anticoagulant effect potentiated.
Pyrimethamine: Megaloblastic anaemia.
Oral contraceptives: Failure of oral contraceptives.
Lab test: Interferes with serum methotrexate assay by the competitive binding protein technique (CBPA).
Jaffe alkaline picrate reaction assay for creatinine: Overestimation of 10% of normal values.
Topical proteolytic enzymes: Silver may inactivate such enzymes.
Typical Dosage for Silver SulphadiazineAdult: Silver sulphadiazine 1 % w/ w cream and 1% w/ v solution is used. Apply as a film of about 2 -3 mm thick directly to the burn or on a sterile gauze dressing. If needed reapply after complete removal of previous applications with saline. Schedule of Silver SulphadiazineN/AStorage Requirements for Silver SulphadiazineStore in a cool dry and dark place.Effects of Missed Dosage of Silver SulphadiazineApply the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Silver SulphadiazineGive supportive measures and symptomatic treatment.Chlorhexidine
About ChlorhexidineA bisbiguanide antimicrobial agent, Anti-infective, antiseptic.Mechanism of Action of ChlorhexidineThis drug has positive charge so it attach to the negative charge cell wall. This destabilizes and destroys the integrity and penetrates bacterial cell membranes. It results precipitation of the cytoplasm and interferes with membrane function by inhibiting oxygen utilization leading to a decrease in cellular ATP levels and cell death. In gram-negative bacteria, chlorhexidine affects the outer membrane allowing the release of periplasmic enzymes. The inner membrane of these organisms is not ruptured but the uptake of small molecules is impaired. At low concentrations chlorhexidine exhibits a bacteriostatic effect while at high concentrations it is bactericidal.Pharmacokinets of ChlorhexidineAbsorption- Poorly from the gastrointestinal tract.
Distribution- 87% bound to the plasma proteins.
Excretion- Excreted through feces.
Onset of Action for ChlorhexidineN/ADuration of Action for ChlorhexidineN/AHalf Life of ChlorhexidineN/ASide Effects of Chlorhexidine1. Bleeding
2. Tender
3. Enlarged gums
4. Cough
5. Congestion or tightness in chest
6. Wheezing
7. Staining of teeth
8. Calculus formation above the gum line
Contra-indications of Chlorhexidine1. Hypersensitivity to the drugSpecial Precautions while taking Chlorhexidine1. Avoid eating or drinking for at least 1 hour after each dose
2. To minimize the staining apply drug with the hollow cup brush tip of the Rota-dent perio tool to only the gum tissue, especially focus on the areas with pockets depths over 4mm
3. You may also alternate drug with custom bleaching trays at home
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationUse with cautionIndications for Chlorhexidine1. Gingivitis
2. Acute and chronic otitis externa (ear infection/inflammation)
3. Periodontal disease
4. Superficial skin infections
5. Irrigation (cleansing) of wounds and as a medicated shampoo for the treatment of certain skin conditions (hot spots or acute moist dermatitis
Interactions for ChlorhexidineN/ATypical Dosage for ChlorhexidineOral rinse solutions - 0.1 percent.
Otic (ear) solutions - 1 percent.
Chlorhexidine solutions - 2 percent.
Chlorhexidine shampoo and conditioner 1 and 2 percent.
As an ear-cleansing agent - flush the ear canal once a day in cases of diagnosed otitis externa.
For skin conditions - clean the area twice daily.
For gingivitis - Chlorhexidine oral solution is applied as directed once a day. In the morning brush and floss for 2 minutes and than rinse with Chlorhexidine for 30 seconds.
Use 1/2 fl. oz. of undiluted. Swish in mouth for 30 seconds. After rinsing for 30 seconds be sure to spit out all the rinse, do NOT swallow any of the rinse. To minimize medicinal taste, DO NOT rinse with water immediately after use. In the evening brush and floss and rinse again for 30 seconds.
Chlorhexidine shampoo and conditioner - once or twice a week.
Pellet (extended-release), Periochip (in a biodegradable matrix of hydrolyzed gelatin cross-linked with glutaraldehyde), Cream, Dressing, Gel, Lotion, Ointment, Sponge forms are also available.
Schedule of ChlorhexidineN/AStorage Requirements for ChlorhexidineStore at room temperature below 77 degree F. Do not freeze.Effects of Missed Dosage of ChlorhexidineTake any missed dose as soon as possible but not if it is almost time for the next dose. If it is time for the next dose, skip the missed dose and resume your regular schedule. Do not "double-up" the dose.Effects of Overdose of ChlorhexidineGive symptomatic and supportive treatment.Home Delivery for Silver sulphadiazine + Chlorhexidine in Your City
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However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for silver sulphadiazine + chlorhexidine and other medicines and health products. Home delivery services for silver sulphadiazine + chlorhexidine may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
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Silver sulphadiazine + Chlorhexidine is a generic medicine name and there are several brands available for it. Some of the brands for silver sulphadiazine + chlorhexidine might be better known than silver sulphadiazine + chlorhexidine itself. If the pharmacy that's willing to deliver medicines to your home doesn't have silver sulphadiazine + chlorhexidine in stock, you can ask for one of the branded alternatives for silver sulphadiazine + chlorhexidine.