Silver Sulphadiazine Pharmacology

Silver Sulphadiazine

About Silver Sulphadiazine
A sulfa derivative, Silver compound, Antiseptic, topical antibacterial.
Mechanism of Action of Silver Sulphadiazine
Silver sulphadiazine is a broad spectrum antiseptic. Silver is released from the drug and it penetrates the bacterial cell wall and bound to bacterial DNA and inhibits DNA replication.
The sulfadiazine moiety has synergistic action and also provides a bacteriostatic action against sensitive organisms
Pharmacokinets of Silver Sulphadiazine
Absorption: After topical administration silver ions and sulphadiazine are released and small amount of sulphadiazine is absorbed in to the systemic circulation. Only a very small amount of silver is absorbed after topical administration
Onset of Action for Silver Sulphadiazine
NULL.
Duration of Action for Silver Sulphadiazine
NULL.
Half Life of Silver Sulphadiazine
N/A
Side Effects of Silver Sulphadiazine
1. Burning
2. Itching
3. Rashes
4. Systemic toxicity when applied on large surface area
5. Transient leucopenia (comes back to normal in 4 -5 days).

Contra-indications of Silver Sulphadiazine
1. Hypersensitivity to Silver sulphadiazine and other Sulphonamide
2. Deep infections

Special Precautions while taking Silver Sulphadiazine
1. Renal impairment
2. Hepatic impairment
3. G6PD deficiency
4. Withdraw the drug immediately if rashes appears

Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated
Children Related Information
Use with caution
NEONATES: Contraindicated
Indications for Silver Sulphadiazine
1. Prevention and treatment of infections in Burns
2. Infected leg ulcers
3. Pressure sores
4. Prophylaxis of infections in skin graft donor sites
5. Preventions of infections in abrasions
6. Wounds

Interactions for Silver Sulphadiazine
Cyclosporine: Decreased efficacy and increased nephrotoxicity with cotrimoxazole.
Methotrexate: Bone marrow depressant effect potentiated.
Phenytoin: Half-life prolonged.
Sulfonylureas: Increased hypoglycemic effect.
Thiazide diuretics: Increased risk of thrombocytopenic purpura in elderly.
Warfarin: Anticoagulant effect potentiated.
Pyrimethamine: Megaloblastic anaemia.
Oral contraceptives: Failure of oral contraceptives.
Lab test: Interferes with serum methotrexate assay by the competitive binding protein technique (CBPA).
Jaffe alkaline picrate reaction assay for creatinine: Overestimation of 10% of normal values.
Topical proteolytic enzymes: Silver may inactivate such enzymes.
Typical Dosage for Silver Sulphadiazine
Adult: Silver sulphadiazine 1 % w/ w cream and 1% w/ v solution is used. Apply as a film of about 2 -3 mm thick directly to the burn or on a sterile gauze dressing. If needed reapply after complete removal of previous applications with saline.
Schedule of Silver Sulphadiazine
N/A
Storage Requirements for Silver Sulphadiazine
Store in a cool dry and dark place.
Effects of Missed Dosage of Silver Sulphadiazine
Apply the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Silver Sulphadiazine
Give supportive measures and symptomatic treatment.

Home Delivery for Silver Sulphadiazine in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including silver sulphadiazine.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for silver sulphadiazine and other medicines and health products. Home delivery services for silver sulphadiazine may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take silver sulphadiazine only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for silver sulphadiazine before they complete the sale. You can get this information while placing the order for silver sulphadiazine with the pharmacy.

Silver Sulphadiazine is a generic medicine name and there are several brands available for it. Some of the brands for silver sulphadiazine might be better known than silver sulphadiazine itself. If the pharmacy that's willing to deliver medicines to your home doesn't have silver sulphadiazine in stock, you can ask for one of the branded alternatives for silver sulphadiazine.