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- Pharmacology For Diclofenac Potassium + Famotidine
Diclofenac Potassium + Famotidine Pharmacology
Diclofenac Potassium + Famotidine
About Diclofenac Potassium + FamotidineN/AMechanism of Action of Diclofenac Potassium + FamotidineN/APharmacokinets of Diclofenac Potassium + FamotidineN/AOnset of Action for Diclofenac Potassium + FamotidineN/ADuration of Action for Diclofenac Potassium + FamotidineN/AHalf Life of Diclofenac Potassium + FamotidineN/ASide Effects of Diclofenac Potassium + FamotidineN/AContra-indications of Diclofenac Potassium + FamotidineN/ASpecial Precautions while taking Diclofenac Potassium + FamotidineN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Diclofenac Potassium + FamotidineN/AInteractions for Diclofenac Potassium + FamotidineN/ATypical Dosage for Diclofenac Potassium + FamotidineN/ASchedule of Diclofenac Potassium + FamotidineN/AStorage Requirements for Diclofenac Potassium + FamotidineN/AEffects of Missed Dosage of Diclofenac Potassium + FamotidineN/AEffects of Overdose of Diclofenac Potassium + FamotidineN/ADiclofenac Potassium
About Diclofenac PotassiumNSAID, anti-inflammatory ,antipyretic and analgesic.Mechanism of Action of Diclofenac PotassiumDiclofenac possess analgesic, anti-inflammatory and antipyretic action. It inhibits the enzyme cyclo-oxygenase and there by inhibits the synthesis of Prostaglandins (((PGs))). It is more potent against cyclo-oxygenase-2 enzyme as compared to other NSAIDs like Indomethacin, Naproxen etc. It reduces intracellular concentrations of free arachidonic acid in leukocyte by altering its release or uptake.Pharmacokinets of Diclofenac PotassiumAbsorption: Diclofenac potassium is rapidly absorbed after oral administration. It undergoes first pass metabolism. Distribution: It is distributed in highly protein bound form. Metabolism: Diclofenac potassium is metabolised in the liver to mainly 4 hydroxy Diclofenac. Excretion: Drug and metabolites are primarily excreted in urine and some amount in the bile.Onset of Action for Diclofenac PotassiumAnalgesic action: with in 60 minutes and Antirheumatic action with in 2 weeksDuration of Action for Diclofenac Potassium12hoursHalf Life of Diclofenac Potassium1-2 hoursSide Effects of Diclofenac Potassium1.Nausea
2.Vomiting
3.Anorexia
4.Diarrhoea
5.Gastrointestinal bleeding
6.Abdominal distress
7.Constipation
8.Flatulence
9.Ulceration of the stomach or intestine
10.Dyspepsia
11.Headache
12.Dizziness
13.Rash
Contra-indications of Diclofenac Potassium1.Hypersensitivity to Diclofenac and other Non steroidal anti inflammatory drugs(((NSAID)))
2.Peptic ulcer
3.Asthma
Special Precautions while taking Diclofenac Potassium1.Hepatic impairment
2.Renal impairment
3.Hypertension
4.Blood clotting disorders
5.Gastrointestinal diseases
6.Proctitis
7.Asthma
8.Cautioned against driving, operating or activities requiring concentration
9.Avoid alcohol
10.Heart failure
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationUse with caution
CHILDREN below 14: contraindicatedIndications for Diclofenac Potassium1.Rheumatoid arthritis
2.Ankylosing spondylitis
3.Acute gout
4.Joint disorders e.g. inflammatory disease in joints, crystal deposition in the joints
5.Osteoarthritis
6.For the relief of pain and inflammation in dental minor surgery and orthopedic
7.Dysmenorrhoea
8.Migraine
Interactions for Diclofenac PotassiumN/ATypical Dosage for Diclofenac PotassiumAdult: 100 - 150 mg / day in 2 - 3 divided doses.
For the relief of pain, Migraine, Dysmenorrhoea: 150 mg / day in 3 divided doses.
Osteoarthritis: 50 mg 2 - 3 times daily
Rheumatoid arthritis: 150 - 200 mg / day in 3 - 4 divided doses.
Schedule of Diclofenac PotassiumHStorage Requirements for Diclofenac PotassiumStore Diclofenac potassium at room temperature in a tightly closed light resistant container.Effects of Missed Dosage of Diclofenac PotassiumTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Diclofenac PotassiumGive supportive measures and symptomatic treatment. Drug can be removed from the body by gastric lavage or by inducing emesis. Absorption of the drug can be reduced by administration of activated charcoal.Famotidine
About FamotidineGuanidine:Thiazole derivative,a histamine H2-receptor antagonist, Anti-secretory,Antiulcer.Mechanism of Action of FamotidineFamotidine is a H2 (Histamine) receptor antagonist. Histamine is the most potent stimulus of acid secretion and acts as the common mediator. H2 receptor is a G-protein coupled receptor. It induces adenylate cyclase which converts ATP to cyclic AMP. This cyclic AMP acts on proton pump and exchange extracellular potassium ion for intracellular hydrogen ion across the parietal cell membrane. Famotidine reversibly competes with Histamine for binding to H2 receptors on the parietal cells and predominantly inhibits basal acid secretion.
Anaesthetic adjuncts: It is used in patients undergoing prolonged operations, caesarian section; obese patients are at increased risk of gastric regurgitation and aspiration pneumonia. It raises pH of gastric juice and also reduces its volume and thus chances of regurgitation. It is now routinely used before prolonged surgery.
Pharmacokinets of FamotidineAbsorption: Famotidine is 40 - 45 % absorbed after oral administration. Distribution: Distributed mainly in unbound form. Metabolism: Famotidine undergoes metabolism in the liver. Excretion: It is excreted mainly in urine and in the faeces.Onset of Action for Famotidine60 minutesDuration of Action for Famotidine2.5-3.5 hoursHalf Life of Famotidine2.5 - 3.5 hoursSide Effects of Famotidine1.Headache
2.Dizziness
3.Constipation
4.Diarrhoea
5.Nausea
6.Vertigo
7.Confusion
8.Rash
9.Thrombocytopenia
10.Leukopenia
Contra-indications of Famotidine1. Hypersensitivity to FamotidineSpecial Precautions while taking Famotidine1.Hepatic impairment
2.Renal impairment
3.Acute Porphyria
Pregnancy Related InformationUse with caution.Old Age Related InformationUse with caution.Breast Feeding Related InformationUse with caution.Children Related InformationUse with caution.
NEONATES: contraindicatedIndications for Famotidine1.Duodenal ulcer
2.Benign gastric ulcer
3.Zollinger- Ellison syndrome
4.Gastroesophageal reflux diseases
5.Acid indigestion
6.Heart burn
7.Sour stomach
8.Preanaesthetic medication (PAM)
Interactions for FamotidineAntacids: Bioavailability of Famotidine slightly decreased, hence antacids in small doses can be given concomitantly.Typical Dosage for FamotidineAdult: 40mg / day
Duodenal ulcer, benign gastric ulcer: 40 mg /day as single dose at bed time or in 2 divided dose (morning and bed time) for 1 - 2 months. Maintenance dose: 20 mg / day at bed time.
Zollinger- Ellison syndrome: 80mg / day in 4 divided doses; dose can be increased if necessary to a maximum up to 800 mg / day
Gastroesophageal reflux disease: 40 mg / day as single dose at bed time or in 2 divided doses (morning and bed time) for maximum 2-3 months, dose can be increased to 80 mg / day in 2 divided doses if needed.
Acid indigestion, Heart burn, Sour stomach: Dose: 20mg/day in 2 divided doses.
PAM: 20mg given night before and in the morning before surgical procedure.
Schedule of FamotidineHStorage Requirements for FamotidineStore at 15 - 30 degree C in a tightly closed container. Protect from light.Effects of Missed Dosage of FamotidineTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of FamotidineGive supportive measures and symptomatic treatment. Drug can be removed from the body by inducing emesis and or by gastric lavage. Activated charcoal is given to reduce the absorption of the drug. Haemodialysis can be done if necessary.Home Delivery for Diclofenac Potassium + Famotidine in Your City
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