Neomycin + Polymyxin B + Bacitracin Pharmacology

Neomycin + Polymyxin B + Bacitracin

About Neomycin + Polymyxin B + Bacitracin
N/A
Mechanism of Action of Neomycin + Polymyxin B + Bacitracin
N/A
Pharmacokinets of Neomycin + Polymyxin B + Bacitracin
N/A
Onset of Action for Neomycin + Polymyxin B + Bacitracin
N/A
Duration of Action for Neomycin + Polymyxin B + Bacitracin
N/A
Half Life of Neomycin + Polymyxin B + Bacitracin
N/A
Side Effects of Neomycin + Polymyxin B + Bacitracin
N/A
Contra-indications of Neomycin + Polymyxin B + Bacitracin
N/A
Special Precautions while taking Neomycin + Polymyxin B + Bacitracin
N/A
Pregnancy Related Information
N/A
Old Age Related Information
N/A
Breast Feeding Related Information
N/A
Children Related Information
N/A
Indications for Neomycin + Polymyxin B + Bacitracin
N/A
Interactions for Neomycin + Polymyxin B + Bacitracin
N/A
Typical Dosage for Neomycin + Polymyxin B + Bacitracin
N/A
Schedule of Neomycin + Polymyxin B + Bacitracin
N/A
Storage Requirements for Neomycin + Polymyxin B + Bacitracin
N/A
Effects of Missed Dosage of Neomycin + Polymyxin B + Bacitracin
N/A
Effects of Overdose of Neomycin + Polymyxin B + Bacitracin
N/A

Neomycin

About Neomycin
An aminoglycoside, Antibiotic, Ammonium Detoxicant.
Mechanism of Action of Neomycin
This aminoglycoside cause protein synthesis inhibition by "irreversibly" bind to specific 30S-subunit proteins and 16S rRNA. Specifically Neomycin binds to four nucleotides of 16S rRNA and a single amino acid of protein S12. This interferes with decoding site in the vicinity of nucleotide 1400 in 16S rRNA of 30S subunit. This region interacts with the wobble base in the anticodon of tRNA. This leads to interference with the initiation complex, misreading of mRNA so incorrect amino acids are inserted into the polypeptide leading to nonfunctional or toxic peptides and the breakup of polysomes into nonfunctional monosomes.
Pharmacokinets of Neomycin
Absorption- Poorly absorbed after oral administration
Distribution- Rapidly distributed in the body after oral administration. 30% bound to the plasma proteins. It crosses the placenta
Metabolism- Not metabolized
Excretion- Excreted through urine and feces (primarily as unchanged form). It also excreted through breast milk
Onset of Action for Neomycin
1 to 4 hr after oral administration
Duration of Action for Neomycin
8hrs after oral administration
Half Life of Neomycin
Its plasma half life is 2 to 3 hrs
Side Effects of Neomycin
1. Rash
2. Diarrhoea
3. Inflammation of the large intestine (colitis)
4. Nausea
5. Vomiting
6. Ototoxicity
7. Damage to the kidneys
8. Damage to vestibular function within the ear
Contra-indications of Neomycin
1. Hypersensitivity to the drug or any ingredients of it
2. Hypersensitivity to other amino glycosides
3. Intestinal obstruction
Special Precautions while taking Neomycin
1. Impaired renal function
2. Neuromuscular disorder
3. Ulcerative bowel lesions
4. Extensive dermatologic conditions
5. Any other eye infection or condition
6. Glaucoma
7. Cataract surgery
8. Blockage of the bowel
9. Eighth-cranial-nerve disease (loss of hearing and/or balance)
10. Kidney disease
11. Myasthenia gravis
12. Parkinson`s disease
13. Ulcers of the bowel
Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated
Children Related Information
Use with caution
Indications for Neomycin
1. Coma due to liver disease
2. Preventing infection following surgery
3. Topical infections
4. Systemic infections
Interactions for Neomycin
N/A
Typical Dosage for Neomycin
Ophthalmic suspension:
Adults-
1 or 2 drops every three or four hours- For eye infection
Oral (solution, tablets):
Adults and teenagers-
1 to 3 grams every six hours for five or six days- coma from liver disease
Adults and teenagers-
1 gram every hour for four hours, then 1 gram every four hours for the rest of a twenty-four hour period; or 1 gram nineteen hours before surgery, 1 gram eighteen hours before surgery, and 1 gram nine hours before surgery- cleaning the bowel before surgery.
Children-
14.7 milligrams mg/kg or 6.7 mg/ pound every four hours for three days
Ear preparation:
Adults and children-
2 to 5 drops into ear canal 3 to 4 times daily for 7 to 10 days- External ear canal infection
Schedule of Neomycin
C
Storage Requirements for Neomycin
Eye preparations store in the refrigerator protected from strong light. Do not freeze. Others are stored at <250C. Keep out of reach of children.
Effects of Missed Dosage of Neomycin
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Neomycin
Give symptomatic and supportive treatment. Provide haemodialysis or peritoneal dialysis to remove the drug. Treated with calcium salts or anticholinesterase to reverses neuromuscular blockade. Administer activated charcoal to prevent the further absorption of drug

Polymyxin B

About Polymyxin B
Basic polypeptide(Polymyxin)antibiotic, Antibiotic.
Mechanism of Action of Polymyxin B
Polymixin B is a member of poly peptide antibiotic. Being poly peptide they exert a detergent like effect. They have high affinity for phospholipids. Peptide molecules orient between these phospholipids and cause cell membrane distortion and amino acids and ions come out with in the cell.Polymixin B is useful against gram negative bacteria only.
Pharmacokinets of Polymyxin B
Absorption: It is well absorbed after parenteral administration.Distribution: It is very widely distributed in the body.Metabolism: It does not undergo significant metabolism.Excretion: It is excreted mainly through urine.
Onset of Action for Polymyxin B
N/A
Duration of Action for Polymyxin B
N/A
Half Life of Polymyxin B
6 hours.
Side Effects of Polymyxin B
1.Pain at the site of injection
2.Nystagmus
3.Flushing
4.Nausea
5.vomiting
6.Diarrhoea
7.Rash
8.Partial deafness
9. Pruritis
10.Ataxia
11.Vertigo
12.Nephrotoxicity
13.Disturbances of vision
Contra-indications of Polymyxin B
1. Hypersensitive to Polymixin B and other polypeptide antibiotic
Special Precautions while taking Polymyxin B
1.Myasthenia gravis
2.Renal dysfunction
Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated
Children Related Information
Use with caution
Indications for Polymyxin B
1.Skin infection
2.Urinary tract infection
3.Burns
4.Enteric infection
Interactions for Polymyxin B
Aminoglycosides: Concurrent use may increase risk of respiratory paralysis and renal dysfunction.
Non-depolarising muscle relaxants: Neuromuscular blockade may be enhanced.
Typical Dosage for Polymyxin B
Adult :( IV) DOSE: 15000 - 25000 units /kg body weight/day in divided dose for 1 - 2 week
Children (IV) dose: 20000 - 40000 units/kg body weight/day in divided dose.
Schedule of Polymyxin B
H
Storage Requirements for Polymyxin B
Store the drug at 10 - 30 degree Celsius
Effects of Missed Dosage of Polymyxin B
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose.Continue the regular schedule.Do not double the dose.
Effects of Overdose of Polymyxin B
Give supportive measures and sumptomatic treatment.

Bacitracin

About Bacitracin
Polypeptide antibiotic.
Mechanism of Action of Bacitracin
Bacitracin is an antibiotic produced by the strain of Bacillus subtilis. It acts by inhibiting bacterial cell wall synthesis. It is active against a variety of gram positive and a few gram negative organisms.
Pharmacokinets of Bacitracin
N/A
Onset of Action for Bacitracin
N/A
Duration of Action for Bacitracin
N/A
Half Life of Bacitracin
N/A
Side Effects of Bacitracin
1.Albuminuria
2.Cylindruria
3.Azotemia
4.Rising blood levels without any increase in dosage.
5.Nausea
6.Vomiting
7.Pain at site of injection
8.Burning, Redness, Rash(topical use)
9.Nephrotoxicity (After parenteral use)

Contra-indications of Bacitracin
Hypersensitivity to the drug
Special Precautions while taking Bacitracin
Hypersensitivity to other antibiotics
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution
Indications for Bacitracin
Locally used for secondarily infected wounds, ulcers, pyodermas and other superficial skin infections.
In the eye: Superficial infections of the eye
Nasal application: Bacitracin-susceptible infections of the upper and lower respiratory tract
IM: Pneumonia and empyema caused by staphylococci in infants
Interactions for Bacitracin
N/A
Typical Dosage for Bacitracin
Infants:IM use
For infants under 2.5kg: 900 units/kg/day in 2 or 3 divided doses.
For infants over 2.5kg:1000 units/kg/day in 2 or 3 divided doses.
Local use: Apply locally once or twice daily in the affected area

Schedule of Bacitracin
N/A
Storage Requirements for Bacitracin
Parenteral preapration: Stored at 2 - 8 degree Celsius.Other preaparations should be stored at 15 - 30 degree Celsius

Effects of Missed Dosage of Bacitracin
Apply the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Bacitracin
Give supportive measures and symptomatic treatment.

Home Delivery for Neomycin + Polymyxin B + Bacitracin in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including neomycin + polymyxin b + bacitracin.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for neomycin + polymyxin b + bacitracin and other medicines and health products. Home delivery services for neomycin + polymyxin b + bacitracin may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take neomycin + polymyxin b + bacitracin only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for neomycin + polymyxin b + bacitracin before they complete the sale. You can get this information while placing the order for neomycin + polymyxin b + bacitracin with the pharmacy.

Neomycin + Polymyxin B + Bacitracin is a generic medicine name and there are several brands available for it. Some of the brands for neomycin + polymyxin b + bacitracin might be better known than neomycin + polymyxin b + bacitracin itself. If the pharmacy that's willing to deliver medicines to your home doesn't have neomycin + polymyxin b + bacitracin in stock, you can ask for one of the branded alternatives for neomycin + polymyxin b + bacitracin.