Dimethicone + Zinc oxide + Calamine + Cetrimide Pharmacology

Dimethicone + Zinc oxide + Calamine + Cetrimide

About Dimethicone + Zinc oxide + Calamine + Cetrimide
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Mechanism of Action of Dimethicone + Zinc oxide + Calamine + Cetrimide
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Pharmacokinets of Dimethicone + Zinc oxide + Calamine + Cetrimide
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Onset of Action for Dimethicone + Zinc oxide + Calamine + Cetrimide
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Duration of Action for Dimethicone + Zinc oxide + Calamine + Cetrimide
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Half Life of Dimethicone + Zinc oxide + Calamine + Cetrimide
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Side Effects of Dimethicone + Zinc oxide + Calamine + Cetrimide
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Contra-indications of Dimethicone + Zinc oxide + Calamine + Cetrimide
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Special Precautions while taking Dimethicone + Zinc oxide + Calamine + Cetrimide
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Pregnancy Related Information
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Old Age Related Information
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Breast Feeding Related Information
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Children Related Information
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Indications for Dimethicone + Zinc oxide + Calamine + Cetrimide
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Interactions for Dimethicone + Zinc oxide + Calamine + Cetrimide
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Typical Dosage for Dimethicone + Zinc oxide + Calamine + Cetrimide
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Schedule of Dimethicone + Zinc oxide + Calamine + Cetrimide
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Storage Requirements for Dimethicone + Zinc oxide + Calamine + Cetrimide
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Effects of Missed Dosage of Dimethicone + Zinc oxide + Calamine + Cetrimide
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Effects of Overdose of Dimethicone + Zinc oxide + Calamine + Cetrimide
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Dimethicone

About Dimethicone
Oral anti -foaming agent, a flexible silicone polymer, Antiflatulent ,Antibloating agent.
Mechanism of Action of Dimethicone
Activated Dimethicone relieves flatulence by dispensing and preventing formation of mucus surrounding gas pockets in the gastro-intestinal tract. It lowers the surface tension of the gas bubbles and bringing together all the small bubbles of gas (coalesce) to form a large bubble, which is then expelled. Thus the gas is freed by belching or passing flatus.
Antiflatulents are added to an antacid gum coating to be effective antigas materials and eliminate trapped gas. The most common antigas material is Dimethicone and when mixed with silicone dioxide becomes Simethicone. Simethicone is also referred to as activated Dimethicone. Simethicone is the most common antigas material and may be the only drug approved antiflatulent.
As the antacid chewing tablet is chewed, the active antacid and antiflatulent in the gum coating is released into the saliva and ingested to give relief from gastrointestinal disturbances in the gastro-intestinal tract.
Besides its antigas effect, Simethicone used in a gum coating can also improve the smoothness of the coating. Activated Dimethicone helps to relieve pain and bloating caused by trapped wind.
Pharmacokinets of Dimethicone
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Onset of Action for Dimethicone
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Duration of Action for Dimethicone
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Half Life of Dimethicone
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Side Effects of Dimethicone
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Contra-indications of Dimethicone
Hypersensitivity to Dimethicone activated
Special Precautions while taking Dimethicone
Kidney failure
Pregnancy Related Information
Use with caution
Old Age Related Information
N/A
Breast Feeding Related Information
Use with caution
Children Related Information
N/A
Indications for Dimethicone
1. Flatulent dyspepsia
2. Postoperative distension
3. Gastric Distention
4. Functional digestive disorders
5. Stomach pain
6. Burning
7. Nausea and excess gas (dyspepsia)
Interactions for Dimethicone
N/A
Typical Dosage for Dimethicone
125 - 166 mg taken half an hour before food.
Dimethicone in a coated chewing gum: 5 mg - 200 mg per piece of coated gum.
With an antacid: 20 mg -50 mg of Dimethicone
Schedule of Dimethicone
N/A
Storage Requirements for Dimethicone
Stored at room temperature (15-30?C) away from moisture and heat.
Effects of Missed Dosage of Dimethicone
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Dimethicone
Give symptomatic and supportive treatment.

Zinc oxide

About Zinc oxide
Zinc compound, A sunscreen,antipruritic.
Mechanism of Action of Zinc oxide
It works by providing a skin barrier and helps in healing and prevent skin irritation. It acts as a sunscreen which absorbs incident solar radiation in the UVA ranges and reduces its transmission to the skin.
Pharmacokinets of Zinc oxide
N/A
Onset of Action for Zinc oxide
N/A
Duration of Action for Zinc oxide
N/A
Half Life of Zinc oxide
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Side Effects of Zinc oxide
1.Rash
2.Hives
3.Difficulty breathing
4.Tightness in the chest
5.Swelling of the mouth, face, lips, or tongue
6.Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
7.Stop using zinc oxide rectal suppositories if you have rectal bleeding or continued pain.

Contra-indications of Zinc oxide
1.Hypersensitivity to Zinc oxide
2.Allergic to zinc, dimethicone, lanolin, cod liver oil, petroleum jelly, parabens, mineral oil, or wax.
Special Precautions while taking Zinc oxide
1.Allergic to Zinc preparations
2.Zinc oxide topical will not treat a bacterial or fungal infection
3.Keep the diaper area clean and dry to prevent worsening of skin rash. Change wet diapers as soon as possible. Allow the skin to dry thoroughly before putting on a fresh diaper
4.Avoid getting this medication in your mouth or eyes
5.Do not use zinc oxide topical on deep skin wounds or severe burns
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
N/A
Indications for Zinc oxide
1.To prevent minor skin irritations such as burns, cuts, poison ivy, poison oak, poison sumac, and diaper rash.
2.As sunscreen
3.Zinc oxide topical (for the skin) is used to treat diaper rash, minor burns, severely chapped skin, or other minor skin irritations.
4.Zinc oxide rectal suppositories are used to treat itching, burning, irritation, and other rectal discomfort caused by hemorrhoids or painful bowel movements
Interactions for Zinc oxide
N/A
Typical Dosage for Zinc oxide
Apply the medicament to the affected part 2 times daily.
Schedule of Zinc oxide
N/A
Storage Requirements for Zinc oxide
Store at 15 - 30 degree C.Protect from heat,light and moisture.Keep out of the reach of children.
Effects of Missed Dosage of Zinc oxide
Apply the missed dose as soon as noticed.
Effects of Overdose of Zinc oxide
Give supportive measures and symptomatic treatment.

Calamine

About Calamine
Antipruritic, mild antiseptic, astringent.
Mechanism of Action of Calamine
Calamine is an anti-pruritics, which are used to relieve itching. Itching can be caused by physical irritation or chemical changes in the skin caused by disease, allergy, inflammation, side-effects of drugs, or reaction to irritant substances. It is a common symptom of skin disorders, e.g. eczema, and infection with lice or worms. Calamine is used as it has a cooling and soothing effect on the skin for symptomatic relief of the itching. It also contains the active ingredient zinc oxide, which has antiseptic properties and helps prevent infection from scratching.
Pharmacokinets of Calamine
N/A
Onset of Action for Calamine
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Duration of Action for Calamine
N/A
Half Life of Calamine
N/A
Side Effects of Calamine
1.Hives
2.Difficulty breathing
3.Swelling of face, lips, tongue, or throat.
Contra-indications of Calamine
1.Hypersensitivity to Calamine
2. Oozing skin
Special Precautions while taking Calamine
1.Do not use on extensive areas of skin for longer than 7 days
2.Avoid contact with mucous membranes and eyes
3.Discontinue if rash or burning sensation occurs
4.Avoid contact with eyes or mouth or nose.
Pregnancy Related Information
May be used
Old Age Related Information
May be used
Breast Feeding Related Information
May be used
Children Related Information
May be used
Indications for Calamine
1.To relieve the itching, pain, and discomfort of minor skin irritations
Interactions for Calamine
N/A
Typical Dosage for Calamine
Apply calamine directly to the skin and rub in gently, allowing to dry on your skin. Apply 3 to 4 times a day.
Schedule of Calamine
N/A
Storage Requirements for Calamine
Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.Keep out of the reach of children.

Effects of Missed Dosage of Calamine
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose.Do not double the dose.Continue the regular schedule.
Effects of Overdose of Calamine
Give supportive measures and sympptomatic treatment.

Cetrimide

About Cetrimide
Quaternary ammonium compound, a cationic surfactant, Antiseptic agent, a detergent ,disinfectant.
Mechanism of Action of Cetrimide
Cetrimide is a cationic surfactant. It destroys or damages the cell membrane by lowering surface tension. It causes microbial protein denaturation and produces antiseptic action.
Pharmacokinets of Cetrimide
Absorption: Cetrimide is poorly absorbed after topical administration through intact skin.
Onset of Action for Cetrimide
N/A
Duration of Action for Cetrimide
N/A
Half Life of Cetrimide
N/A
Side Effects of Cetrimide
1.Skin irritation
2.Redness of the skin
3.Local sensitivity
Contra-indications of Cetrimide
1.Hypersensitivity to Cetrimide
Special Precautions while taking Cetrimide
1.For external use only
2.Avoid contact with eyes, middle ear, meninges, brain
3.Avoid use in body cavities
4.Wash thoroughly with water
5.Prolonged applications
Pregnancy Related Information
May be used.
Old Age Related Information
May be used.
Breast Feeding Related Information
May be used
Children Related Information
May be used.
Indications for Cetrimide
Antiseptic and disinfectant
1.Pyoderma
2.Wounds
3.Cuts
4.Burns
5.Pruritis
6.Furunculosis
7.Preoperative applications to hands
8.Disinfectant hospital vessels
Interactions for Cetrimide
Incompatible with soaps and other anionic surfactants, iodine alkali hydroxides.
Typical Dosage for Cetrimide
Adult: Apply 2 - 3 times daily
As Disinfectant: Cetrimide 15% and Cetrimide 20 % are used
As antiseptic: Cetrimide 3% and: Cetrimide 7.5 % are used.
Schedule of Cetrimide
N/A
Storage Requirements for Cetrimide
Store in a cool, dry and dark place.
Effects of Missed Dosage of Cetrimide
Apply the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Cetrimide
Give supportive measures and symptomatic treatment

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