Glycerine + Omega 6 fatty acids Pharmacology
Glycerine + Omega 6 fatty acids
Glycerine
Metabolism: Metabolized in the liver, kidney, and other tissues.
Excretion: Excreted through urine.
1.Nausea
2.Vomiting
3.Headache
4.Confusion
5.Disorientation
6.Dehydration
7.Amnesia in elderly people
Rectal administration :
1. Griping
2. Diarrhea
3. Nausea
4. Vomiting
5. Perianal irritation
6. Abdominal cramps
7. Weakness
8. Dizziness
9. Syncope
Ophthalmic administration :
1. Irritation
2. Pain
1. Hypersensitivity to Glycerine
2. Severe dehydration
3. Anuria
4. Congestive heart failure
5. Pulmonary edema
6. Hypervolemia
Rectal administration is contraindicated in:-
1. Signs of appendicitis
2. Acute surgical abdomen
3. Fecal impaction
4. Intestinal obstruction
5. Undiagnosed abdominal pain
2. Diabetes
3. Cardiac disease
4. Renal impairment
5. Hepatic impairment
6. Hemolytic anemia
7. While using oral glycerol drink plenty of fluid concomitantly
2. As osmotic diuretic
3. As Emollient
4. Constipation
4. To reduce intraocular or intracranial tension
5. Glaucoma
As osmotic diuretic: 1.5g/kg as oral solution.
Topical:
Emollient: Apply a 50% solution over dry and chapped skin
Orally or per Rectum:
For evacuation: 50 to 75% Glycerine per rectum or orally.
Adults and children > 6 years: Insert 1 suppository; high in the rectum and retain for 15 minutes. Alternatively, 5-15 ml can be used as an enema.
Children < 6 years: Insert 1 infant suppository 1-2 times daily as needed. Alternatively, 2-5 ml as an enema may be used.
Neonates: 0.5 ml/kg/dose as an enema.
I.V.:
To reduce intraocular or intracranial tension: 10% Glycerine intravenously.
Oral: 1 to 1.8g/kg orally. Additional doses may be administered at 5 hour intervals. If used prior to ocular surgery, dosing should begin 1-1.5 hours before the procedure
For use during ophthalmic examination:
Adults: Instill 1 or 2 drops of Ophthalmic dosage prior to examination of edematous cornea.
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