Glycerine Pharmacology

Glycerine

About Glycerine
N/A
Mechanism of Action of Glycerine
Glycerine is a sweet clear viscous liquid with dehydrating property. It produces a warm sensation and irritates mucous membranes. When used as a suppository and applied to anal canal it induces evacuation. Glycerine soothes the irritated skin so it is used as a component of cough mixtures. When a 50% solution of Glycerine in water is applied to dry and chapped skin it acts as an emollient. When used a 10% solution I.V. it reduces intraocular or intracranial pressure. When used as a diuretic it significantly increases the osmolality of plasma and tubular fluid. It is pharmacologically inert and freely filtered at glomerulus and undergoes limited reabsorption by renal tubule and acts as osmotic diuretic.
Pharmacokinets of Glycerine
Absorption: Well absorbed orally.
Metabolism: Metabolized in the liver, kidney, and other tissues.
Excretion: Excreted through urine.
Onset of Action for Glycerine
N/A
Duration of Action for Glycerine
N/A
Half Life of Glycerine
30 to 45 minutes.
Side Effects of Glycerine
Oral administration :
1.Nausea
2.Vomiting
3.Headache
4.Confusion
5.Disorientation
6.Dehydration
7.Amnesia in elderly people
Rectal administration :
1. Griping
2. Diarrhea
3. Nausea
4. Vomiting
5. Perianal irritation
6. Abdominal cramps
7. Weakness
8. Dizziness
9. Syncope
Ophthalmic administration :
1. Irritation
2. Pain
Contra-indications of Glycerine
Oral Glycerine is contraindicated in :-
1. Hypersensitivity to Glycerine
2. Severe dehydration
3. Anuria
4. Congestive heart failure
5. Pulmonary edema
6. Hypervolemia
Rectal administration is contraindicated in:-
1. Signs of appendicitis
2. Acute surgical abdomen
3. Fecal impaction
4. Intestinal obstruction
5. Undiagnosed abdominal pain
Special Precautions while taking Glycerine
1. Confused mental states
2. Diabetes
3. Cardiac disease
4. Renal impairment
5. Hepatic impairment
6. Hemolytic anemia
7. While using oral glycerol drink plenty of fluid concomitantly
Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution.
Breast Feeding Related Information
Contraindicated
Children Related Information
May be used
Indications for Glycerine
1. As an ingredient of cough mixtures
2. As osmotic diuretic
3. As Emollient
4. Constipation
4. To reduce intraocular or intracranial tension
5. Glaucoma
Interactions for Glycerine
N/A
Typical Dosage for Glycerine
Oral:
As osmotic diuretic: 1.5g/kg as oral solution.
Topical:
Emollient: Apply a 50% solution over dry and chapped skin
Orally or per Rectum:
For evacuation: 50 to 75% Glycerine per rectum or orally.
Adults and children > 6 years: Insert 1 suppository; high in the rectum and retain for 15 minutes. Alternatively, 5-15 ml can be used as an enema.
Children < 6 years: Insert 1 infant suppository 1-2 times daily as needed. Alternatively, 2-5 ml as an enema may be used.
Neonates: 0.5 ml/kg/dose as an enema.
I.V.:
To reduce intraocular or intracranial tension: 10% Glycerine intravenously.
Oral: 1 to 1.8g/kg orally. Additional doses may be administered at 5 hour intervals. If used prior to ocular surgery, dosing should begin 1-1.5 hours before the procedure
For use during ophthalmic examination:
Adults: Instill 1 or 2 drops of Ophthalmic dosage prior to examination of edematous cornea.
Schedule of Glycerine
N/A
Storage Requirements for Glycerine
Store at room temperature at a range of 15 to 30 degree C in a well closed container. Protect from direct sunlight and moisture. Avoid metal containers and contact with strong oxidizing agents.
Effects of Missed Dosage of Glycerine
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Glycerine
Give supportive measures and symptomatic treatment.

Home Delivery for Glycerine in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including glycerine.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for glycerine and other medicines and health products. Home delivery services for glycerine may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take glycerine only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for glycerine before they complete the sale. You can get this information while placing the order for glycerine with the pharmacy.

Glycerine is a generic medicine name and there are several brands available for it. Some of the brands for glycerine might be better known than glycerine itself. If the pharmacy that's willing to deliver medicines to your home doesn't have glycerine in stock, you can ask for one of the branded alternatives for glycerine.