Bevacizumab Pharmacology

Bevacizumab

About Bevacizumab
Humanized monoclonal antibody, angiogenesis inhibitor. anti neoplastic.
Mechanism of Action of Bevacizumab
Bevacizumab is a recombinant humanized monoclonal antibody. It inhibits the biologic activity of human vascular endothelial growth factor (VEGF).Bevacizumab binds to VEGF and inhibits the interaction of VEGF to its receptors (VEGFR1 and VEGFR2). VEGF is an angiogenic growth factor that regulates vascular proliferation and permeability and inhibits apoptosis of new blood vessels. This may reduce tumor cell growth.In colorectal cancer patients, the Bevacizumab causes reduction of microvascular growth and inhibition of metastatic disease progression.
Pharmacokinets of Bevacizumab
N/A
Onset of Action for Bevacizumab
N/A
Duration of Action for Bevacizumab
N/A
Half Life of Bevacizumab
20days
Side Effects of Bevacizumab
1.Diarrhoea
2.Nausea
3.Vomiting
4.Asthenia
5.Pain
6.Headache
7.Hypertension
8.Anorexia
9.Stomatitis
10.Constipation
11.Upper respiratory infection
12.Epistaxis
13.Dyspnea
14.Exfoliative dermatitis
15.Proteinuria.
16.Deep Vein Thrombosis
17.Hypertension
18.Neutropenia
19.Leucopenia
Contra-indications of Bevacizumab
Hypersensitivity to Bevacizumab
Special Precautions while taking Bevacizumab
1.Congestive Heart Failure
2.Arterial Thromboembolic Events
3.Gastrointestinal Perforations
4.Hypertension
5.Leukoencephalopathy Syndrome
6.Proteinuria
7.Surgery
Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated
Children Related Information
Contraindicated
Indications for Bevacizumab
Metastatic carcinoma of the colon or rectum
Interactions for Bevacizumab
N/A
Typical Dosage for Bevacizumab
Adult: 5 - 10 mg/kg every 14 days Bevacizumab is used along with intravenous 5-Flurouracil
Schedule of Bevacizumab
N/A
Storage Requirements for Bevacizumab
Store in the refrigerator at 2- 8 degree C. Do not freeze. Keep all medicines away from children . Mixed solution should be stored up to 8 hours in the refrigerator. Discard if not used within 8 hours.
Effects of Missed Dosage of Bevacizumab
The doctor should be informed immediately if a dose is missed
Effects of Overdose of Bevacizumab
Give supportive measures and symptomatic treatment.

Home Delivery for Bevacizumab in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including bevacizumab.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for bevacizumab and other medicines and health products. Home delivery services for bevacizumab may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take bevacizumab only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for bevacizumab before they complete the sale. You can get this information while placing the order for bevacizumab with the pharmacy.

Bevacizumab is a generic medicine name and there are several brands available for it. Some of the brands for bevacizumab might be better known than bevacizumab itself. If the pharmacy that's willing to deliver medicines to your home doesn't have bevacizumab in stock, you can ask for one of the branded alternatives for bevacizumab.