Homatropine Pharmacology

Homatropine

About Homatropine
Ophthalmic Anticholinergic alkaloid (Muscarinic antagonist), Mydriatic, cycloplegic.
Mechanism of Action of Homatropine
Homatropine is a muscarinic receptor blocker. It nonselectively inhibits the muscarinic actions of Acetylcholine. Homatropine blocks the muscarinic receptors in the muscles of the eye which are involved in controlling the pupil size and the shape of the lens. It blocks the cholinergic nerves supplying the smooth muscles of iris and produces Mydriasis. It also causes paralysis of ciliary muscle and produces a tightening of the suspensory ligament and results in flattening of the lens and a consequent increase in focal length. Because of paralysis of muscle cannot constrict the pupils for viewing near object or prevents the eye from accommodating for near vision (Cycloplegia). It has less potent antimuscarinic action and short duration of action as compared to Atropine.
Homatropine is given as eye drops to dilate the pupil and relax the lens so that eye examinations can be carried out thoroughly. It is often used to aid eye examinations in young children.
Pharmacokinets of Homatropine
Absorption: Homatropine is readily absorbed after ophthalmic use.
Onset of Action for Homatropine
Rapid
Duration of Action for Homatropine
1 - 3 days
Half Life of Homatropine
N/A
Side Effects of Homatropine
1.Photophobia
2.Irritation
3.Contact dermatitis
4.Blurring of near vision
5.Mydriasis
6.Palpitation
7.Inflammation of the lining of the eye
8.Pain
9.Lacrimation (hyperemia)
Contra-indications of Homatropine
1.Hypersensitivity to Homatropine and other belladonna alkaloids
2.Narrow angle glaucoma
Special Precautions while taking Homatropine
1.Avoid use of soft contact lens
2.Use caution while driving vehicle or operating machine
3.Raised intraocular pressure
4.Stop the use of medicament if any allergic reactions occur
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated
Children Related Information
Use with caution
Indications for Homatropine
1.Dilating the pupil to aid examination of the eye
2.Cycloplegic for use in uveitis and during refraction
Interactions for Homatropine
N/A
Typical Dosage for Homatropine
Homatropine 2% and 5% eye drop is available.
Eye drop: 1 - 2 drop in each eye.
Cycloplegic refraction:
Instill 1 - 2 drop of 2% solution in the eye and repeat if needed in 5 - 10 minutes
Instill 1 drop of 5% solution in the eye and repeat if needed in 5 - 10 minutes
Uveitis: Instill 1 - 2 drop of 2% or 5% solution in the eye and repeat every 3 - 4 hours
Children:
Uveitis: Instill 1 drop of 2% solution in the eye and every 8 - 12 hours





Schedule of Homatropine
N/A
Storage Requirements for Homatropine
Store in a cool dry place in a tightly closed container. Protect from heat and light. Keep out of the reach of children. Discard the drug 1 month after opening.
Effects of Missed Dosage of Homatropine
Instill the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Homatropine
A topical ocular overdose of an ophthalmic product containing Homatropine may be flushed from the eye with warm tap water.

Home Delivery for Homatropine in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including homatropine.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for homatropine and other medicines and health products. Home delivery services for homatropine may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take homatropine only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for homatropine before they complete the sale. You can get this information while placing the order for homatropine with the pharmacy.

Homatropine is a generic medicine name and there are several brands available for it. Some of the brands for homatropine might be better known than homatropine itself. If the pharmacy that's willing to deliver medicines to your home doesn't have homatropine in stock, you can ask for one of the branded alternatives for homatropine.