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- Pharmacology For Dipivefrine + Benzalkonium Chloride
Dipivefrine + Benzalkonium Chloride Pharmacology
Dipivefrine + Benzalkonium Chloride
About Dipivefrine + Benzalkonium ChlorideN/AMechanism of Action of Dipivefrine + Benzalkonium ChlorideN/APharmacokinets of Dipivefrine + Benzalkonium ChlorideN/AOnset of Action for Dipivefrine + Benzalkonium ChlorideN/ADuration of Action for Dipivefrine + Benzalkonium ChlorideN/AHalf Life of Dipivefrine + Benzalkonium ChlorideN/ASide Effects of Dipivefrine + Benzalkonium ChlorideN/AContra-indications of Dipivefrine + Benzalkonium ChlorideN/ASpecial Precautions while taking Dipivefrine + Benzalkonium ChlorideN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Dipivefrine + Benzalkonium ChlorideN/AInteractions for Dipivefrine + Benzalkonium ChlorideN/ATypical Dosage for Dipivefrine + Benzalkonium ChlorideN/ASchedule of Dipivefrine + Benzalkonium ChlorideN/AStorage Requirements for Dipivefrine + Benzalkonium ChlorideN/AEffects of Missed Dosage of Dipivefrine + Benzalkonium ChlorideN/AEffects of Overdose of Dipivefrine + Benzalkonium ChlorideN/ADipivefrine
About DipivefrineAdrenergic Alpha/Beta agonist, prodrug of adrenaline, Ophthalmic Vasoconstrictor, Antiglaucoma ,miotic.Mechanism of Action of DipivefrineDipivefrine is an ester of Adrenaline and Pivalic acid. It is converted in the eye to active adrenaline. Adrenaline then acts on adrenoceptors in the walls of blood vessels in the eye and produces vasoconstriction and reduces blood flow. This will leads to decreased production of aqueous humor. Adrenaline is also increases the drainage of the fluid from the eye. It opens the drainage channels in the eye and allows fluid to leave the eye and relieves pressure. As adrenaline decreases the amount of fluid inside the eye, it is useful in treating glaucoma.Pharmacokinets of DipivefrineAbsorption: Dipivefrine is easily penetrated in to the anterior chamber of the eye.Onset of Action for Dipivefrine30 minutesDuration of Action for Dipivefrine12 hoursHalf Life of DipivefrineN/ASide Effects of Dipivefrine1 Burning
2.Stinging
3.Conjunctivitis
4.Mydriasis
5.Photophobia
6.Conjunctival hyperemia
7.Arrhythmia
8.Hypertension
9.Tachycardia
Contra-indications of Dipivefrine1.Hypersensitivity to Dipivefrine, Adrenaline
2.Angle closure glaucoma
Special Precautions while taking Dipivefrine1.Asthma
2 Aphakia
3.Arrhythmia
4.Avoid use of soft contact lens for minimum of 15 minutes after instillation of drops
5.Do not operate machine or drive vehicle since it produce blurred vision
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationContraindicated
NEONATES: contraindicatedIndications for Dipivefrine1.Open angle glaucoma
2.Ocular hypertension
Interactions for DipivefrineN/ATypical Dosage for DipivefrineN/ASchedule of DipivefrineN/AStorage Requirements for DipivefrineStore in a cool dry place in a tightly closed container. Protect from heat and light. Keep out of the reach of children. Discard the drug 1 month after opening.Effects of Missed Dosage of DipivefrineTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of DipivefrineA topical ocular overdose of an ophthalmic product containing Dipivefrine may be flushed from the eye with warm tap water.Benzalkonium Chloride
About Benzalkonium ChlorideA nitrogenous cationic surfactant, Quaternary ammonium compound, Antiseptic,Disinfectant, A vaginal contraceptive spermicidal agent.Mechanism of Action of Benzalkonium ChlorideThe mechanism of bactericidal/microbicidal action is due to disruption of intermolecular interactions. This cause dissociation of cellular membrane bilayers, which compromises cellular permeability controls and induces leakage of cellular contents. Other biomolecular complexes within the bacterial cell can also undergo dissociation. It also inactivates the enzyme produced by different microorganisms. It also has spermicidal action. They work by damaging and killing sperm in the vagina. Therefore, the sperm are not able to travel from the vagina into the uterus and fallopian tubes, where fertilization usually takes place.Pharmacokinets of Benzalkonium ChlorideN/AOnset of Action for Benzalkonium ChlorideN/ADuration of Action for Benzalkonium ChlorideN/AHalf Life of Benzalkonium ChlorideN/ASide Effects of Benzalkonium Chloride1. Chills
2. Confusion
3. Dizziness
4. Fever
5. Lightheadedness
6. Muscle aches
7. Sunburn-like skin rash
8. Cloudy or bloody urine
9. Increased frequency of urination
10. Pain in the bladder or lower abdomen
11. Pain on urination; thick
12. White or curd-like vaginal discharge-with use of cervical caps or diaphragms
13. Vaginal dryness
14. Odor
Contra-indications of Benzalkonium Chloride1. Hypersensitivity to the drug
2. Allergies, irritations, or infections of the genitals
3. Recent abortion
4. Sores on the genitals (sex organs)
5. Irritation of the vagina
Special Precautions while taking Benzalkonium ChlorideDiscontinue use if you have abnormal discharge or vaginal burning or itching.Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with cautionIndications for Benzalkonium Chloride1. Antisepsis of skin, mucous membranes, and wounds.
2. Preoperative preparation of the skin, surgeons` hand and arm soaks
3. Treatment of wounds
4. Preservation of ophthalmic solutions
5. Irrigations of the eye, body cavities, bladder, urethra
6. Vaginal douching.
7. Contraceptives
Interactions for Benzalkonium ChlorideN/ATypical Dosage for Benzalkonium ChlorideVaginal suppositories dosage form (preventing pregnancy):
Adults and teenagers-
For use alone: One suppository inserted into the vagina at least ten minutes but not longer than four hours before each time you have sexual intercourse.
With a diaphragm: After the diaphragm with spermicide has been placed into the vagina, insert one suppository at least ten minutes, but not longer than four hours, before each time you have sexual intercourse. Also, insert another suppository before sexual intercourse if six hours have passed since you inserted the diaphragm
Schedule of Benzalkonium ChlorideN/AStorage Requirements for Benzalkonium ChlorideStore at controlled room temperature, away from light and excessive heat. Keep out of reach of children.Effects of Missed Dosage of Benzalkonium ChlorideTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Benzalkonium ChlorideN/AHome Delivery for Dipivefrine + Benzalkonium Chloride in Your City
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