Timolol Pharmacology

Timolol

About Timolol
Nonselective Beta Adrenergic,Blocker,Ophthalmic- Antiglaucoma,antimigraine.
Mechanism of Action of Timolol
Timolol is a non selective beta blocker. It inhibits the beta receptors (?2) present in the eye such as in the ciliary body epithelium and blood vessels. This will leads to decreased aqueous production and reduced intraocular pressure. Aqueous humor production is activated by ? receptor mediated cyclic AMP phosphokinase pathway. Beta receptor blockers will decreases the intracellular cyclic AMP level and reduces intraocular pressure. Another mechanism is that Timolol decreases the ocular blood flow which decreases ultrafiltration responsible for aqueous production.
Pharmacokinets of Timolol
Absorption: Absorption after ophthalmic use is minimal.
Onset of Action for Timolol
30 minutes
Duration of Action for Timolol
12- 24 hours
Half Life of Timolol
N/A
Side Effects of Timolol
1. Irritation
2. Burning
3. Bronchospasm
4. Blurred vision
5. Increased sensitivity of the eyes to light
6. Redness of eyes
7. Discoloration of the eyeball
8. Eye pain
Contra-indications of Timolol
1. Hypersensitivity to Timolol
2. Bronchial asthma
3. Chronic obstructive pulmonary diseases
4. Sinus Bradycardia
5. Heart failure
6. Cardiogenic shock
7. AV block (2nd or 3rd degree)
Special Precautions while taking Timolol
1. Chronic bronchitis
2. Emphysema
3. Diabetes mellitus
4. Hyperthyroidism
5. Myasthenia gravis
6. Closed angle glaucoma
7. Gradually withdraw the drug in patient with Thyrotoxicosis
8. Cerebrovascular insufficiency
9. Avid use of soft contact lenses.
Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Contraindicated
NEONATES: Contraindicated
Indications for Timolol
1. Open angle glaucoma
2. Ocular hypertension
Interactions for Timolol
N/A
Typical Dosage for Timolol
Timolol 0.25, and 0.5% eye drops are used.
Instill 1 drop in to the affected eye for 1 - 2 times daily.
Schedule of Timolol
H
Storage Requirements for Timolol
Store in a cool dry place in a tightly closed container. Protect from heat and light. Keep out of the reach of children. Discard the drug 1 month after opening.
Effects of Missed Dosage of Timolol
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Timolol
A topical ocular overdose of an ophthalmic product containing Timolol may be flushed from the eye with warm tap water.

Home Delivery for Timolol in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including timolol.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for timolol and other medicines and health products. Home delivery services for timolol may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take timolol only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for timolol before they complete the sale. You can get this information while placing the order for timolol with the pharmacy.

Timolol is a generic medicine name and there are several brands available for it. Some of the brands for timolol might be better known than timolol itself. If the pharmacy that's willing to deliver medicines to your home doesn't have timolol in stock, you can ask for one of the branded alternatives for timolol.